Abstract:
:Mitochondrial morphological and structural changes play a role in several cellular processes, including apoptosis. We recently reported that mitochondrial elongation is also critical to sustain cell viability during macroautophagy. During macroautophagy unopposed mitochondrial fusion leads to organelle elongation both in vitro and in vivo. Longer mitochondria are protected from being degraded and possess more cristae where activity of the ATP synthase is increased, optimizing ATP production in times of nutrient restriction.
journal_name
Autophagyjournal_title
Autophagyauthors
Gomes LC,Scorrano Ldoi
10.4161/auto.7.10.16771subject
Has Abstractpub_date
2011-10-01 00:00:00pages
1251-3issue
10eissn
1554-8627issn
1554-8635pii
16771journal_volume
7pub_type
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