Abstract:
:The Syrian hamster Harderian gland (HG) is a juxtaorbital organ exhibiting marked gender-associated morphological differences. Regarding contents of porphyrins, this gland is a good model for studying physiological oxidative stress effects, since both sexes present strong (in females) and moderate (in males) levels of this stress in normal conditions. We have recently showed that autophagic processes are in the Syrian hamster HG as the first result of an elevated porphyrin metabolism observed in both sexes. In this case, autophagy is not a cell death mechanism per se but a constant renovation system which allows to continuing with the normal gland activity. Moreover, we have also reported that this gland presents invasive processes, resembling to tumoral progression, and are, additionally, a consequence of a strong oxidative stress environment that is mainly observed in female Syrian hamster HG and in minor proportion in male HG. Here, we present additional data and discuss a model of melatonin action on these cited processes by which melatonin would be able to destroy the equilibrium between both detoxifying actions. We postulate that melatonin reduces oxidative stress level into HG as direct antioxidant. This decrease of free radicals produces the autophagy inhibition due to outbreak signal disappearance in HG. Under these events and regarding the huge contents of porphyrins that this gland supports, the invasive process triggers.
journal_name
Autophagyjournal_title
Autophagyauthors
Coto-Montes A,Tomás-Zapico Cdoi
10.4161/auto.2.2.2351subject
Has Abstractpub_date
2006-04-01 00:00:00pages
126-8issue
2eissn
1554-8627issn
1554-8635pii
2351journal_volume
2pub_type
杂志文章相关文献
Autophagy文献大全abstract::A coding polymorphism of the critical autophagic effector ATG16L1 (T300A) increases the risk of Crohn disease, but how this mutation influences the function of ATG16L1 has remained unclear. In a recent report, we showed that the A300 allele alters the ability of the C-terminal WD40 domain of ATG16L1 to interact with p...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1216303
更新日期:2016-11-01 00:00:00
abstract::Understanding the role of autophagy in cancer has been limited by the inability to measure this dynamic process in formalin-fixed tissue. We considered that 3-dimensional models including ex vivo tumor, such as we have developed for studying mesothelioma, would provide valuable insights. Using these models, in which w...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1173799
更新日期:2016-07-02 00:00:00
abstract::Understanding of the mechanism for myeloid differentiation provides important insights into the hematopoietic developmental processes. By using an ESC-derived myeloid progenitor cell model, we found that CSF2/GM-CSF triggered macrophage differentiation and activation of the MTOR signaling pathway. Activation or inhibi...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1578040
更新日期:2019-07-01 00:00:00
abstract::Actin plays indispensable roles in autophagosome biogenesis. Branched actin networks assembled within phagophore membranes are required for generating the autophagosome membrane shape and movement. The ARP2/3 complex and its regulators, such as JMY (junction mediating and regulatory protein, p53 cofactor), translocate...
journal_title:Autophagy
pub_type: 评论,社论
doi:10.1080/15548627.2018.1564417
更新日期:2019-03-01 00:00:00
abstract::One of the major side effects of cisplatin chemotherapy is toxic acute kidney injury due to preferential accumulation of cisplatin in renal proximal tubule epithelial cells and the subsequent injury to these cells. Apoptosis is known as a major mechanism of cisplatin-induced cell death in renal tubular cells. We have ...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.6309
更新日期:2008-07-01 00:00:00
abstract::Reactive oxygen species (ROS) that accumulate under oxidative pressure cause severe damage to cellular components, and induce various cellular responses, including apoptosis, programmed necrosis and autophagy, depending on the cellular setting. Various studies have described ROS-induced autophagy, but only a few direc...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19288
更新日期:2012-03-01 00:00:00
abstract::The understanding of the membrane flow process during autophagosome formation is essential to illuminate the role of autophagy under various disease-causing conditions. Atg9 is the only identified integral membrane protein required for autophagosome formation, and it is thought to cycle between the membrane sources an...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.3.7699
更新日期:2009-04-01 00:00:00
abstract::Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a major modulator of cellular lipid metabolism and organelle differentiation. To understand whether autophagy is involved in the processes of dysregulated fatty acid oxidation and induced oxidative stress accompanying prostatic carcinogenesis, we characte...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.6.1.10700
更新日期:2010-01-01 00:00:00
abstract::Chronic lung inflammation is accepted as being associated with the development of lung cancer caused by nickel exposure. Therefore, identifying the molecular mechanisms that lead to a nickel-induced sustained inflammatory microenvironment that causes transformation of human bronchial epithelial cells is of high signif...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1196313
更新日期:2016-10-02 00:00:00
abstract::The Atg1/ULK1 complex plays a central role in starvation-induced autophagy, integrating signals from upstream sensors such as MTOR and AMPK and transducing them to the downstream autophagy pathway. Much progress has been made in the last few years in understanding the mechanisms by which the complex is regulated throu...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.23323
更新日期:2013-02-01 00:00:00
abstract::Macroautophagy/autophagy is the main intracellular catabolic pathway in neurons that eliminates misfolded proteins, aggregates and damaged organelles associated with ageing and neurodegeneration. Autophagy is regulated by both MTOR-dependent and -independent pathways. There is increasing evidence that autophagy is com...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1385674
更新日期:2018-01-01 00:00:00
abstract::A steady increase in life expectancy has resulted in an equivalent increase in elderly patients who are more susceptible to diseases than young patients. In a recent study, we found that in both in vitro and in vivo models of ischemia/reperfusion (I/R), a loss of ATG4B is causatively associated with the increased sens...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.8.1.18391
更新日期:2012-01-01 00:00:00
abstract::Glioblastoma is one of the most aggressive human cancers with poor prognosis, and therefore a critical need exists for novel therapeutic strategies for management of glioblastoma patients. Itraconazole, a traditional antifungal drug, has been identified as a novel potential anticancer agent due to its inhibitory effec...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.28912
更新日期:2014-07-01 00:00:00
abstract::The best-characterized process of autophagy is macroautophagy. Many an article or talk has started with the phrase "...macroautophagy, hereafter referred to as autophagy." This one will be different because we are going to learn more about the person most responsible for increasing our understanding of chaperone-media...
journal_title:Autophagy
pub_type: 传,历史文章,杂志文章
doi:10.4161/auto.5.8.9476
更新日期:2009-11-01 00:00:00
abstract::Numerous studies have reported that inhibition of MTOR (mechanistic target of rapamycin kinase) clearly reduces Alzheimer disease neuropathological hallmarks in mouse models. This has resulted in calls for the use of the MTOR inhibitor rapamycin for the treatment of dementia in humans. Unfortunately, intervention with...
journal_title:Autophagy
pub_type: 评论,杂志文章
doi:10.1080/15548627.2019.1615823
更新日期:2019-08-01 00:00:00
abstract::Multiple stress pathways result in the induction of autophagy and apoptosis. Current methods (e.g., protein gel blot, microscopy) do not offer quantitative single-cell resolution, thus making it difficult to discern if these pathways are mutually exclusive or, in some situations, cooperative in executing cell death. W...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.9.16252
更新日期:2011-09-01 00:00:00
abstract::Macroautophagy/autophagy is an important catabolic process for maintaining cellular homeostasis by adapting to various stress conditions. Autophagy is mediated by a double-membrane autophagosome, which sequesters a portion of cytoplasmic components for delivery to the vacuole. Several autophagy-related (ATG) genes pla...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1746592
更新日期:2020-04-02 00:00:00
abstract::Autophagy is an evolutionarily conserved catabolic process that involves the engulfment of cytoplasmic contents in a closed double-membrane structure, called the autophagosome, and their subsequent delivery to the vacuole/lysosomes for degradation. Genetic screens in Saccharomyces cerevisiae have identified more than ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.21163
更新日期:2012-10-01 00:00:00
abstract::Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms remain poorly understood. Here, we show that the RNA-binding protein ZFP36/TTP (ZFP36 ring finger protein) plays a crucial role in regulating ferroptosis in hepatic stellate cells (HSCs). Upon exposure to ferroptosis-indu...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1687985
更新日期:2020-08-01 00:00:00
abstract::Flies expressing the most common Parkinson disease (PD)-related mutation, LRRK2-G2019S, in their dopaminergic neurons show loss of visual function and degeneration of the retina, including mitochondrial abnormalities, apoptosis and autophagy. Since the photoreceptors that degenerate are not dopaminergic, this demonstr...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.24397
更新日期:2013-06-01 00:00:00
abstract::SPHK1 (sphingosine kinase 1), a regulator of sphingolipid metabolites, plays a causal role in the development of hepatocellular carcinoma (HCC) through augmenting HCC invasion and metastasis. However, the mechanism by which SPHK1 signaling promotes invasion and metastasis in HCC remains to be clarified. Here, we repor...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1291479
更新日期:2017-05-04 00:00:00
abstract::The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) and the enzyme that produces it, SPHK1 (sphingosine kinase 1), regulate many processes important for the etiology of cancer. It has been suggested that SPHK1 levels are regulated by the tumor suppressor protein TP53, a key regulator of cell cycle arre...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2018.1429875
更新日期:2018-01-01 00:00:00
abstract::Autophagy removes long-lived proteins and damaged organelles and is important for maintaining cellular homeostasis. It can also serve in innate immunity to remove intracellular pathogens. As such, viruses have evolved different mechanisms to subvert this innate immune response. We have recently demonstrated that hepat...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6566
更新日期:2008-08-01 00:00:00
abstract::In a series of studies into the fate of endothelial cells exposed to non-enzymatically glycated collagen I, a model of cytotoxic molecules relevant to diabetic vasculopathy, we demonstrate that cells either undergo apoptosis or become prematurely senescent despite relatively spared telomeres and telomerase activity. O...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5904
更新日期:2008-05-01 00:00:00
abstract::Age-related macular degeneration (AMD) is a complex, degenerative and progressive eye disease that usually does not lead to complete blindness, but can result in severe loss of central vision. Risk factors for AMD include age, genetics, diet, smoking, oxidative stress and many cardiovascular-associated risk factors. A...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.24546
更新日期:2013-07-01 00:00:00
abstract::Although several oncogenes enhance autophagic flux, the molecular mechanism and consequences of oncogene-induced autophagy remain to be clarified. We have recently shown that expression of oncogenic H-Ras (V12) promotes autophagy through upregulation of Beclin 1 and the BH3-only protein Noxa. H-Ras-expressing cells un...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.8.15821
更新日期:2011-08-01 00:00:00
abstract::The upregulation of autophagosome formation in response to nutrient deprivation requires significant intracellular membrane rearrangements that are poorly understood. Recent findings have implicated COPII-coated vesicles, well known as ER-Golgi cargo transport carriers, as key players in macroautophagy. The role of CO...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.1080/15548627.2017.1287657
更新日期:2017-05-04 00:00:00
abstract::Autophagy is a conserved homeostatic process in which cytoplasmic contents are degraded and recycled. Two ubiquitin-like conjugation pathways are required for the generation of autophagosomes, and ATG5 is necessary for both of these processes. Studies of mice deficient in ATG5 reveal a key role for autophagy in T lymp...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.23484
更新日期:2013-04-01 00:00:00
abstract::Alzheimer disease (AD) is usually accompanied by two prominent pathological features, cerebral accumulation of amyloid-β (Aβ) plaques and presence of MAPT/tau neurofibrillary tangles. Dysregulated clearance of Aβ largely contributes to its accumulation and plaque formation in the brain. Macroautophagy/autophagy is a l...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2021.1872187
更新日期:2021-01-19 00:00:00
abstract::Autophagosome formation is a complex cellular process, which requires major membrane rearrangements leading to the creation of a relatively large double-membrane vesicle that directs its contents to the lysosome for degradation. Although various membrane compartments have been identified as sources for autophagosomal ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.21486
更新日期:2012-11-01 00:00:00