Abstract:
:Flies expressing the most common Parkinson disease (PD)-related mutation, LRRK2-G2019S, in their dopaminergic neurons show loss of visual function and degeneration of the retina, including mitochondrial abnormalities, apoptosis and autophagy. Since the photoreceptors that degenerate are not dopaminergic, this demonstrates nonautonomous degeneration, and a spread of pathology. This provides a model consistent with Braak's hypothesis on progressive PD. The loss of visual function is specific for the G2019S mutation, implying the cause is its increased kinase activity, and is enhanced by increased neuronal activity. These data suggest novel explanations for the variability in animal models of PD. The specificity of visual loss to G2019S, coupled with the differences in neural firing rate, provide an explanation for the variability between people with PD in visual tests.
journal_name
Autophagyjournal_title
Autophagyauthors
Hindle SJ,Elliott CJdoi
10.4161/auto.24397subject
Has Abstractpub_date
2013-06-01 00:00:00pages
936-8issue
6eissn
1554-8627issn
1554-8635pii
24397journal_volume
9pub_type
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