Abstract:
:Inhibition of the autophagic pathway has recently revealed promising results in increasing pro-death activity of multiple cancer therapeutics. Here, we discuss our findings regarding the autophagy-blocking and anti-neoplastic effects of a synthetic sphingosine analog, FTY720, in mantle cell lymphoma (MCL). We also emphasize how FTY720 enhances the pro-death activity of the fully humanized monoclonal antibody milatuzumab by inhibiting the autophagy-lysosome dependent degradation of its therapeutic target, CD74. Our results provide justification for further evaluation of FTY720 and milatuzumab as a combination therapy for this aggressive B-cell malignancy.
journal_name
Autophagyjournal_title
Autophagyauthors
Alinari L,Baiocchi RA,Praetorius-Ibba Mdoi
10.4161/auto.19050subject
Has Abstractpub_date
2012-03-01 00:00:00pages
416-7issue
3eissn
1554-8627issn
1554-8635pii
19050journal_volume
8pub_type
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