Vitamin D improves sunburns by increasing autophagy in M2 macrophages.

abstract：:Autophagy is involved in cellular clearance of aggregate-prone proteins, thereby having a cytoprotective function. Studies in yeast have shown that the PI 3-kinase Vps34 and its regulatory protein kinase Vps15 are important for autophagy, but the possible involvement of these proteins in autophagy in a multicellular a...

journal_title：Autophagy

authors： Lindmo K,Brech A,Finley KD,Gaumer S,Contamine D,Rusten TE,Stenmark H

更新日期：2008-05-01 00:00:00

abstract：:Cytotoxic necrotizing factor 1 is a bacterial protein toxin from Escherichia coli that is able to activate the Rho GTPases and to hinder apoptosis and mitotic catastrophe. Upon exposure to toxin, cells undergo a complex framework of changes, including cytoskeleton remodeling and multinucleation. These cells also show ...

journal_title：Autophagy

authors： Fiorentini C,Malorni W

更新日期：2006-10-01 00:00:00

abstract：:Bulk degradation and nutrient recycling are events associated with autophagy. The core components of the autophagy machinery have been elucidated recently using molecular and genetic approaches. In particular, two ubiquitin-like proteins, ATG8 and ATG12, which conjugate with phosphatidylethanolamine (PE) and ATG5, res...

journal_title：Autophagy

authors： Xiao S,Chye ML

更新日期：2010-08-01 00:00:00

abstract：:Autophagy is a highly conserved homeostatic pathway that plays an important role in tumor development and progression by acting on cancer cells in a cell-autonomous mechanism. However, the solid tumor is not an island, but rather an ensemble performance that includes nonmalignant stromal cells, such as macrophages. A ...

journal_title：Autophagy

authors： Chen P,Cescon M,Bonaldo P

更新日期：2014-02-01 00:00:00

abstract：:The European autophagy consortium Driving next-generation autophagy researchers towards translation (DRIVE) held its kick-off meeting in Groningen on the 14th and 15th of June 2018. This Marie Skłodowska-Curie Early Training Network was approved under the European Union's Horizon 2020 Research and Innovation Program a...

journal_title：Autophagy

authors： Kraft C,Boya P,Codogno P,Elazar Z,Eskelinen EL,Farrés J,Kirkin V,Jungbluth H,Martinez A,Pless O,Primard C,Proikas-Cezanne T,Simonsen A,Reggiori F

更新日期：2019-02-01 00:00:00

abstract：:It has been a longstanding problem to identify specific and efficient pharmacological modulators of autophagy. Recently, we found that depletion of acetyl-coenzyme A (AcCoA) induced autophagic flux, while manipulations designed to increase cytosolic AcCoA efficiently inhibited autophagy. Thus, the cell permeant ester ...

journal_title：Autophagy

authors： Mariño G,Pietrocola F,Kong Y,Eisenberg T,Hill JA,Madeo F,Kroemer G

更新日期：2014-05-01 00:00:00

abstract：:It has not been elucidated whether or not autophagy is induced by rhabdoviral G glycoproteins (G) in vertebrate organisms for which rhabdovirus infection is lethal. Our work provides the first evidence that both mammalian (vesicular stomatitis virus, VSV) and fish (viral hemorrhagic septicemia virus, VHSV, and spring ...

journal_title：Autophagy

authors： García-Valtanen P,Ortega-Villaizán Mdel M,Martínez-López A,Medina-Gali R,Pérez L,Mackenzie S,Figueras A,Coll JM,Estepa A

更新日期：2014-09-01 00:00:00

abstract：:Autophagy is a conserved membrane traffic pathway that equips eukaryotic cells to capture cytoplasmic components within a double-membrane vacuole, or autophagosome, for delivery to lysosomes. Although best known as a mechanism to survive starvation, autophagy is now recognized to combat infection by a variety of micro...

journal_title：Autophagy

authors： Dubuisson JF,Swanson MS

更新日期：2006-07-01 00:00:00

abstract：:The critical role of the cellular autophagy pathway in viral infection and pathogenesis has become increasingly apparent. Mounting evidences suggest that viruses have developed different strategies to meticulously modulate intracellular autophagy for their own benefits, thereby either promoting efficient viral replica...

journal_title：Autophagy

authors： Liang C,E X,Jung JU

更新日期：2008-04-01 00:00:00

abstract：:The lack of a rapid and quantitative autophagy assay has substantially hindered the development and implementation of autophagy-targeting therapies for a variety of human diseases. To address this critical issue, we developed a novel autophagy assay using the newly developed Cyto-ID fluorescence dye. We first verified...

journal_title：Autophagy

authors： Guo S,Liang Y,Murphy SF,Huang A,Shen H,Kelly DF,Sobrado P,Sheng Z

更新日期：2015-01-01 00:00:00

abstract：:Abnormal aggregation of SNCA/?-synuclein plays a crucial role in Parkinson disease (PD) pathogenesis. SNCA levels determine its toxicity, and its accumulation, even to a small extent, may be a risk factor for neurodegeneration. One of the main pathways for SNCA degradation is chaperone-mediated autophagy (CMA), a sele...

journal_title：Autophagy

authors： Xilouri M,Brekk OR,Kirik D,Stefanis L

更新日期：2013-12-01 00:00:00

abstract：:To examine the functional significance and detailed morphological characteristics of starvation-induced autophagy in the adult heart, we starved green fluorescent protein (GFP)-microtubule-associated protein 1 light chain 3 (LC3) transgenic mice for up to 3 days. Electron microscopy revealed that, after as little as 1...

journal_title：Autophagy

authors： Takemura G,Kanamori H,Goto K,Maruyama R,Tsujimoto A,Fujiwara H,Seishima M,Minatoguchi S

更新日期：2009-10-01 00:00:00

abstract：:The relationship between macroautophagy/autophagy and miRNA in regulating cancer cell motility is not clearly delineated. Here, we found that induction of BECN1-dependent or -independent autophagy decreased ubiquitin-binding proteins SQSTM1/p62 and CALCOCO2/NDP52. Downregulation of SQSTM1 (but not CALCOCO2) led to a d...

journal_title：Autophagy

authors： Liao CC,Ho MY,Liang SM,Liang CM

更新日期：2018-01-01 00:00:00

abstract：:Deficiency in decidualization has been widely regarded as an important cause of spontaneous abortion. Generalized decidualization also includes massive infiltration and enrichment of NK cells. However, the underlying mechanism of decidual NK (dNK) cell residence remains largely unknown. Here, we observe that the incre...

journal_title：Autophagy

authors： Lu H,Yang HL,Zhou WJ,Lai ZZ,Qiu XM,Fu Q,Zhao JY,Wang J,Li DJ,Li MQ

更新日期：2020-11-01 00:00:00

abstract：:The best-characterized process of autophagy is macroautophagy. Many an article or talk has started with the phrase "...macroautophagy, hereafter referred to as autophagy." This one will be different because we are going to learn more about the person most responsible for increasing our understanding of chaperone-media...

journal_title：Autophagy

authors： Dice JF

更新日期：2009-11-01 00:00:00

abstract：:Macroautophagy is an intracellular catabolic process involved in the formation of multiple membrane structures ranging from phagophores to autophagosomes and autolysosomes. Dysfunction of macroautophagy is implicated in both physiological and pathological conditions. To date, 38 autophagy-related (ATG) genes have been...

journal_title：Autophagy

authors： Xie Y,Kang R,Sun X,Zhong M,Huang J,Klionsky DJ,Tang D

更新日期：2015-01-01 00:00:00

abstract：:The molecular mechanism of macroautophagy/autophagy induction has been intensively studied, but little is known about downregulation of autophagy and how this process is restricted. In particular, how is autophagy maintained at an appropriate homeostatic level when cells are subjected to prolonged stress? In this stud...

journal_title：Autophagy

authors： Feng Y,Klionsky DJ

更新日期：2016-07-02 00:00:00

abstract：:An increasing body of data links endoplasmic reticulum (ER) function to autophagy. Not surprisingly, then, some aberrant proteins in the ER can be destroyed either via ER associated degradation (ERAD), which is proteasome-mediated, or via autophagy. One such substrate is the "Z" variant of the alpha-1 protease inhibit...

journal_title：Autophagy

authors： Brodsky JL,Scott CM

更新日期：2007-11-01 00:00:00

abstract：:Cargo-based assays have proven invaluable in the study of macroautophagy in yeast and mammalian cells. Proteomic analysis of autolysosomes identified the metabolic enzyme, betaine homocysteine methyltransferase (BHMT), as a potential cargo-based, end-point marker for mammalian macroautophagy. To test whether degradati...

journal_title：Autophagy

authors： Mercer CA,Kaliappan A,Dennis PB

更新日期：2008-02-01 00:00:00

abstract：:The NIH-funded center for autophagy research named Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence, located at the University of New Mexico Health Science Center is now completing its second year as a working center with a mission to promote autophagy research locally, nationally...

journal_title：Autophagy

authors： Deretic V,Prossnitz E,Burge M,Campen MJ,Cannon J,Liu KJ,Liu M,Hall P,Sklar LA,Allers L,Mariscal L,Garcia SA,Weaver J,Baehrecke EH,Behrends C,Cecconi F,Codogno P,Chen GC,Elazar Z,Eskelinen EL,Fourie B,Gozuacik D

更新日期：2019-10-01 00:00:00

abstract：:Accumulating evidence has demonstrated that macroautophagy/autophagy plays an essential role in self-renewal and differentiation in embryonic hematopoiesis. Here, according to the RNA sequencing data sets of 5 population cells related to hematopoietic stem cell (HSC) formation during mouse embryogenesis (endothelial c...

journal_title：Autophagy

authors： Hu Y,Huang Y,Yi Y,Wang H,Liu B,Yu J,Wang D

更新日期：2017-04-03 00:00:00

abstract：:Aged and damaged mitochondria can be selectively degraded by specific autophagic elimination, termed mitophagy. Defects in mitophagy have been increasingly linked to several diseases including neurodegenerative diseases, metabolic diseases and other aging-related diseases. However, the molecular mechanisms of mitophag...

journal_title：Autophagy

authors： Xu G,Li T,Chen J,Li C,Zhao H,Yao C,Dong H,Wen K,Wang K,Zhao J,Xia Q,Zhou T,Zhang H,Gao P,Li A,Pan X

更新日期：2018-01-01 00:00:00

abstract：:The flank organ of the Syrian hamster, which shows a biodynamic response to androgen stimulation, is considered a good model for studying the androgen effect on sebaceous gland and hair. This organ is susceptible to programmed cell death (PCD), a prominent feature associated with sexual organ adjustment. We have recen...

journal_title：Autophagy

authors： Vega-Naredo I,Tomas-Zapico C,Coto-Montes A

更新日期：2009-02-01 00:00:00

abstract：:Autophagy is a degradative pathway conserved among eukaryotes. It is a major route for degradation of long-lived proteins and entire organelles, such as peroxisomes. Atg26, a sterol glucosyltransferase, is specifically required for micro- and macropexophagy, but not for starvation-induced bulk autophagy in Pichia past...

journal_title：Autophagy

authors： Cao Y,Klionsky DJ

更新日期：2007-01-01 00:00:00

abstract：:Macroautophagy (referred to as autophagy) is an evolutionarily conserved, bulk-destruction process in eukaryotes. During this process, the cytoplasm containing long-lived proteins and organelles is engulfed into double-membrane autophagosomes, and ultimately undergoes enzymatic degradation within lysosomes. Autophagy ...

journal_title：Autophagy

authors： Wang L,Dong Z,Huang B,Zhao B,Wang H,Zhao J,Kung H,Zhang S,Miao J

更新日期：2010-11-01 00:00:00

abstract：:While autophagy is believed to be beneficial for life-span extension, it is controversial which forms or aspects of autophagy are responsible for this effect. We addressed this topic by analyzing the life span of yeast autophagy mutants under caloric restriction, a longevity manipulation. Surprisingly, we discovered t...

journal_title：Autophagy

authors： Tang F,Watkins JW,Bermudez M,Gray R,Gaban A,Portie K,Grace S,Kleve M,Craciun G

更新日期：2008-10-01 00:00:00

abstract：:In 2013, Dr. Lora Hooper and colleagues described the induction of antibacterial macroautophagy/autophagy in intestinal epithelial cells as a cytoprotective host defense mechanism against invading Salmonella enterica serovar Typhimurium (S. Typhimurium). Canonical autophagy functions in a primarily degradative capacit...

journal_title：Autophagy

authors： Delorme-Axford E,Klionsky DJ

更新日期：2018-01-01 00:00:00

abstract：:The class III phosphatidylinositol (PtdIns)-3 kinase, PIK3C3/VPS34, forms multiple complexes and regulates a variety of cellular functions, especially in intracellular vesicle trafficking and autophagy. Even though PtdIns3P, the product of PIK3C3, is thought to be a critical membrane marker for the autophagosome, it i...

journal_title：Autophagy

authors： Kim J,Guan KL

更新日期：2013-07-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) have fewer and immature mitochondria than somatic cells and mainly rely on glycolysis for energy source. During somatic cell reprogramming, somatic mitochondria and other organelles get remodeled. However, events of organelle remodeling and interaction during somatic cell reprogr...

journal_title：Autophagy

authors： Xiang G,Yang L,Long Q,Chen K,Tang H,Wu Y,Liu Z,Zhou Y,Qi J,Zheng L,Liu W,Ying Z,Fan W,Shi H,Li H,Lin X,Gao M,Liu J,Bao F,Li L,Duan L,Li M,Liu X

更新日期：2017-09-02 00:00:00

abstract：:Macroautophagy/autophagy, an evolutionarily conserved eukaryotic bioprocess, plays an important role in the bulk degradation of intracellular macromolecules, organelles, and invading pathogens. PIK3C3/VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3) functions as a key protein in autophagy initiation and ...

journal_title：Autophagy

authors： Xie W,Jin S,Cui J

更新日期：2020-06-01 00:00:00