Autosomal dominant retinitis pigmentosa-associated gene PRPF8 is essential for hypoxia-induced mitophagy through regulating ULK1 mRNA splicing.

abstract：:Oxidative stress (OS) stimulates autophagy in different cellular systems, but it remains controversial if this rule can be generalized. We have analyzed the effect of chronic OS induced by the parkinsonian toxin paraquat (PQ) on autophagy in astrocytoma cells and primary astrocytes, which represent the first cellular ...

journal_title：Autophagy

authors： Janda E,Lascala A,Carresi C,Parafati M,Aprigliano S,Russo V,Savoia C,Ziviani E,Musolino V,Morani F,Isidoro C,Mollace V

更新日期：2015-01-01 00:00:00

abstract：:IRGM is a genetic risk factor for several autoimmune diseases. However, the mechanism of IRGM-mediated protection in autoimmunity remains undetermined. The abnormal activation of type I interferon (IFN) response is one of the significant factors in the pathogenesis of several autoimmune diseases. In our recent study, ...

journal_title：Autophagy

authors： Nath P,Jena KK,Mehto S,Chauhan NR,Sahu R,Dhar K,Srinivas K,Chauhan S,Chauhan S

更新日期：2020-08-19 00:00:00

abstract：:The role of autophagy, a catabolic lysosome-dependent pathway, has recently been recognized in a variety of disorders, including Pompe disease, which results from a deficiency of the glycogen-degrading lysosomal hydrolase acid-alpha glucosidase (GAA). Skeletal and cardiac muscle are most severely affected by the progr...

journal_title：Autophagy

authors： Raben N,Baum R,Schreiner C,Takikita S,Mizushima N,Ralston E,Plotz P

更新日期：2009-01-01 00:00:00

abstract：:Hepatic stellate cell (HSC) activation, the transition from a resident quiescent HSC to a myofibroblastic collagen-producing HSC, is a fundamental feature of liver fibrosis. Autophagy has been implicated in major liver pathologies, such as HCV infection and hepatocarcinoma. However, its role in HSC biology is largely ...

journal_title：Autophagy

authors： Thoen LF,Guimarães EL,Grunsven LA

更新日期：2012-01-01 00:00:00

abstract：:Science informs art, and art informs science. Both processes involve creativity and imagination, and collaboration between scientists and artists often leads to new insights in both fields. We took advantage of the power of artistic imagery to demonstrate a dynamic cellular process, autophagy. In particular, we depict...

journal_title：Autophagy

authors： Goodsell DS,Klionsky DJ

更新日期：2010-01-01 00:00:00

abstract：:The acetylase inhibitor, spermidine and the deacetylase activator, resveratrol, both induce autophagy and prolong life span of the model organism Caenorhabditis elegans in an autophagydependent fashion. Based on these premises, we investigated the differences and similarities in spermidine and resveratrol-induced auto...

journal_title：Autophagy

authors： Mariño G,Morselli E,Bennetzen MV,Eisenberg T,Megalou E,Schroeder S,Cabrera S,Bénit P,Rustin P,Criollo A,Kepp O,Galluzzi L,Shen S,Malik SA,Maiuri MC,Horio Y,López-Otín C,Andersen JS,Tavernarakis N,Madeo F,Kroemer G

更新日期：2011-06-01 00:00:00

abstract：:This Editor's Corner may sound like the title of a mystery novel, but it actually reflects a question I have about the puncta articles that appear in Autophagy (or rather, the ones that do not appear). In particular, I am surprised by the number of solicitations sent out for puncta that are either ignored, or, less fr...

journal_title：Autophagy

authors： Klionsky DJ

更新日期：2017-09-02 00:00:00

abstract：:KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive. Here, we report that extracellular KRASG12D is essential for pancreatic tumor-ass...

journal_title：Autophagy

authors： Dai E,Han L,Liu J,Xie Y,Kroemer G,Klionsky DJ,Zeh HJ,Kang R,Wang J,Tang D

更新日期：2020-11-01 00:00:00

abstract：:Macroautophagy sequesters superflous cytosol and organelles into double-membraned autophagosomes. Over 30 autophagy-related (ATG) genes have been identified without elucidating the molecular details of autophagosome biogenesis. All proposed models for autophagosome formation require membrane fusion events (Fig. 1). Pr...

journal_title：Autophagy

authors： Krick R,Bremer S,Welter E,Eskelinen EL,Thumm M

更新日期：2011-02-01 00:00:00

abstract：:Numerous studies have reported that inhibition of MTOR (mechanistic target of rapamycin kinase) clearly reduces Alzheimer disease neuropathological hallmarks in mouse models. This has resulted in calls for the use of the MTOR inhibitor rapamycin for the treatment of dementia in humans. Unfortunately, intervention with...

journal_title：Autophagy

authors： Carosi JM,Sargeant TJ

更新日期：2019-08-01 00:00:00

abstract：:Target of rapamycin complex 1 (TORC1) is an evolutionarily conserved protein kinase complex, whose activation in response to nutrients suppresses autophagy. In mammalian cells, amino-acid stimuli induce lysosomal translocation and activation of MTORC1 through the RRAG GTPase heterodimer, which is tethered to the surfa...

journal_title：Autophagy

authors： Fukuda T,Shiozaki K

更新日期：2018-01-01 00:00:00

abstract：:As a selective degradation system, chaperone-mediated autophagy (CMA) is essential for maintaining cellular homeostasis and survival under stress conditions. Increasing evidence points to an important role for the dysfunction of CMA in the pathogenesis of Parkinson disease (PD). However, the mechanisms by which CMA re...

journal_title：Autophagy

authors： Wang B,Cai Z,Tao K,Zeng W,Lu F,Yang R,Feng D,Gao G,Yang Q

更新日期：2016-08-02 00:00:00

abstract：:Regulation of intestinal epithelial turnover is a key component of villus maintenance in the intestine. The balance of cell turnover can be perturbed by various extrinsic factors including the cytokine TNF, a cell signaling protein that mediates both proliferative and cytotoxic outcomes. Under conditions of infection ...

journal_title：Autophagy

authors： Jung H,Leal-Ekman JS,Lu Q,Stappenbeck TS

更新日期：2019-11-01 00:00:00

abstract：:The conserved target of rapamycin (TOR) kinase is a central regulator of cell growth in response to nutrient availability. TOR forms 2 structurally and functionally distinct complexes, TORC1 and TORC2, and negatively regulates autophagy via TORC1. Here we demonstrate TOR also operates independently through the TORC2 s...

journal_title：Autophagy

authors： Vlahakis A,Powers T

更新日期：2014-01-01 00:00:00

abstract：:Ticks are long-lived hematophagous arthropods and have tolerance to starvation. They can survive without food during the host-seeking period for several months to years. To understand how ticks obtain energy over a long period of non-feeding (starvation), we focused on autophagy, a crucial proteolysis system via the l...

journal_title：Autophagy

authors： Umemiya-Shirafuji R,Matsuo T,Liao M,Boldbaatar D,Battur B,Suzuki H,Fujisaki K

更新日期：2010-05-01 00:00:00

abstract：:Neuroblastoma is the most common extracranial solid tumor in childhood. Despite intense multimodal therapy and many improvements through basic scientific and clinical research, the successful response of advanced-stage patients to chemotherapy remains poor. Autophagy is a cytoprotective mechanism that may help advance...

journal_title：Autophagy

authors： Oehme I,Lodrini M,Brady NR,Witt O

更新日期：2013-12-01 00:00:00

abstract：:Inhibition of the autophagic pathway has recently revealed promising results in increasing pro-death activity of multiple cancer therapeutics. Here, we discuss our findings regarding the autophagy-blocking and anti-neoplastic effects of a synthetic sphingosine analog, FTY720, in mantle cell lymphoma (MCL). We also emp...

journal_title：Autophagy

authors： Alinari L,Baiocchi RA,Praetorius-Ibba M

更新日期：2012-03-01 00:00:00

abstract：:The aging process drives the progressive deterioration of an organism and is thus subject to a complex interplay of regulatory and executing mechanisms. Our understanding of this process eventually aims at the delay and/or prevention of age-related pathologies, among them the age-dependent decrease in cognitive perfor...

journal_title：Autophagy

authors： Sigrist SJ,Carmona-Gutierrez D,Gupta VK,Bhukel A,Mertel S,Eisenberg T,Madeo F

更新日期：2014-01-01 00:00:00

abstract：:Degradation of intracellular components via macroautophagy is a complex multistep process that starts with the sequestration of cytosolic cargo in a de novo formed double-membrane vesicle or autophagosome. This compartment acquires the hydrolases required for cargo digestion by fusion with lysosomes. In contrast to th...

journal_title：Autophagy

authors： Koga H,Kaushik S,Cuervo AM

更新日期：2010-08-01 00:00:00

abstract：:Mutations in the ER-associated VAPB/ALS8 protein cause amyotrophic lateral sclerosis and spinal muscular atrophy. Previous studies have argued that ER stress may underlie the demise of neurons. We find that loss of VAP proteins (VAPs) leads to an accumulation of aberrant lysosomes and impairs lysosomal degradation. VA...

journal_title：Autophagy

authors： Mao D,Lin G,Tepe B,Zuo Z,Tan KL,Senturk M,Zhang S,Arenkiel BR,Sardiello M,Bellen HJ

更新日期：2019-07-01 00:00:00

abstract：:Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies low back pain. Overloading-induced cell death, especially endogenous stem cell death, is the leading factor that undermines intrinsic repair and aggravates IDD. Previous research has separately studied the effect of oxygen conc...

journal_title：Autophagy

authors： He R,Wang Z,Cui M,Liu S,Wu W,Chen M,Wu Y,Qu Y,Lin H,Chen S,Wang B,Shao Z

更新日期：2021-01-18 00:00:00

abstract：:Autophagy is a complex, multi-step and biologically important pathway mediated by autophagosomes and autolysosomes. Accurately dissecting and detecting different stages of autophagy is important to elucidate its molecular mechanism and thereby facilitate the discovery of pharmaceutical molecules. We herein reported a ...

journal_title：Autophagy

authors： Chen JJ,Jing J,Chang H,Rong Y,Hai Y,Tang J,Zhang JL,Xu P

更新日期：2013-06-01 00:00:00

abstract：:The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) and the enzyme that produces it, SPHK1 (sphingosine kinase 1), regulate many processes important for the etiology of cancer. It has been suggested that SPHK1 levels are regulated by the tumor suppressor protein TP53, a key regulator of cell cycle arre...

journal_title：Autophagy

authors： Lima S,Takabe K,Newton J,Saurabh K,Young MM,Leopoldino AM,Hait NC,Roberts JL,Wang HG,Dent P,Milstien S,Booth L,Spiegel S

更新日期：2018-01-01 00:00:00

abstract：:The two structurally related, major lysosomal membrane proteins LAMP-1 and LAMP-2 were for a long time regarded as crucial for the protection of the lysosomal membrane from the hostile lumenal environment. However, recent studies on the effects of single and combined LAMP-deficiency in mice reveal alternative function...

journal_title：Autophagy

authors： Saftig P,Beertsen W,Eskelinen EL

更新日期：2008-05-01 00:00:00

abstract：:Under stress conditions cells activate different response pathways which result in cell survival or apoptosis depending on: (1) the nature of the insults, (2) the type, if acute or chronic stress, and (3) how long the stress persists. Generally, autophagy is induced early to sustain cell survival and inhibit cell deat...

journal_title：Autophagy

authors： Corazzari M,Fimia GM,Piacentini M

更新日期：2012-08-01 00:00:00

abstract：:Actin plays indispensable roles in autophagosome biogenesis. Branched actin networks assembled within phagophore membranes are required for generating the autophagosome membrane shape and movement. The ARP2/3 complex and its regulators, such as JMY (junction mediating and regulatory protein, p53 cofactor), translocate...

journal_title：Autophagy

authors： Liu X,Klionsky DJ

更新日期：2019-03-01 00:00:00

abstract：:Deficiency in decidualization has been widely regarded as an important cause of spontaneous abortion. Generalized decidualization also includes massive infiltration and enrichment of NK cells. However, the underlying mechanism of decidual NK (dNK) cell residence remains largely unknown. Here, we observe that the incre...

journal_title：Autophagy

authors： Lu H,Yang HL,Zhou WJ,Lai ZZ,Qiu XM,Fu Q,Zhao JY,Wang J,Li DJ,Li MQ

更新日期：2020-11-01 00:00:00

abstract：:One of the major side effects of cisplatin chemotherapy is toxic acute kidney injury due to preferential accumulation of cisplatin in renal proximal tubule epithelial cells and the subsequent injury to these cells. Apoptosis is known as a major mechanism of cisplatin-induced cell death in renal tubular cells. We have ...

journal_title：Autophagy

authors： Kaushal GP,Kaushal V,Herzog C,Yang C

更新日期：2008-07-01 00:00:00

abstract：:Shigella, the causative agent of human bacillary dysentery, invades the host cell, rapidly breaking the phagosome and multiplying in the cytosol. Here, we summarize our recent work showing the targeting of the leftover membrane remnants to autophagy together with trapped membrane-associated signaling molecules recruit...

journal_title：Autophagy

authors： Dupont N,Lafont F

更新日期：2009-11-01 00:00:00

abstract：:Premenopausal women have better survival than men after intracerebral hemorrhage, which is associated with iron overproduction and autophagy induction. To examine the participation of neuronal autophagy and estrogen receptor α (ERα) in the E 2-mediated protection, PC12 neurons treated with Atg7 (autophagy-related prot...

journal_title：Autophagy

authors： Chen CW,Chen TY,Tsai KL,Lin CL,Yokoyama KK,Lee WS,Chiueh CC,Hsu C

更新日期：2012-10-01 00:00:00