Abstract:
:Macroautophagy sequesters superflous cytosol and organelles into double-membraned autophagosomes. Over 30 autophagy-related (ATG) genes have been identified without elucidating the molecular details of autophagosome biogenesis. All proposed models for autophagosome formation require membrane fusion events (Fig. 1). Previous studies assumed that the autophagic machinery mediates these membrane fusions in a SNARE-independent manner and identified the ubiquitin-like protein Atg8 as a key component especially for elongation of the forming autophagosome. However, if and how Atg8 mediates membrane fusion and why a ubiquitin-like protein is needed for autophagosome biogenesis remained open questions. Since nuclear envelope growth and fusion of Golgi fragments are topologically similar to autophagosome formation and depend on the AAA (+) ATPase p97/VCP and p47 we analyzed the involvement of their yeast homologues Cdc48 and Shp1 in macroautophagy.
journal_name
Autophagyjournal_title
Autophagyauthors
Krick R,Bremer S,Welter E,Eskelinen EL,Thumm Mdoi
10.4161/auto.7.2.14383subject
Has Abstractpub_date
2011-02-01 00:00:00pages
250-1issue
2eissn
1554-8627issn
1554-8635pii
14383journal_volume
7pub_type
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