听力与言语-语言病理学

行为科学

医学伦理学

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  • Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway.

    abstract::Alzheimer disease (AD) is usually accompanied by two prominent pathological features, cerebral accumulation of amyloid-β (Aβ) plaques and presence of MAPT/tau neurofibrillary tangles. Dysregulated clearance of Aβ largely contributes to its accumulation and plaque formation in the brain. Macroautophagy/autophagy is a l...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2021.1872187

    authors: Wani A,Al Rihani SB,Sharma A,Weadick B,Govindarajan R,Khan SU,Sharma PR,Dogra A,Nandi U,Reddy CN,Bharate SS,Singh G,Bharate SB,Vishwakarma RA,Kaddoumi A,Kumar A

    更新日期:2021-01-19 00:00:00

  • HIF1A Alleviates compression-induced apoptosis of nucleus pulposus derived stem cells via upregulating autophagy.

    abstract::Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies low back pain. Overloading-induced cell death, especially endogenous stem cell death, is the leading factor that undermines intrinsic repair and aggravates IDD. Previous research has separately studied the effect of oxygen conc...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2021.1872227

    authors: He R,Wang Z,Cui M,Liu S,Wu W,Chen M,Wu Y,Qu Y,Lin H,Chen S,Wang B,Shao Z

    更新日期:2021-01-18 00:00:00

  • ATG7 is dispensable for LC3-PE conjugation in thioglycolate-elicited mouse peritoneal macrophages.

    abstract::Thioglycolate-elicited macrophages exhibit abundant conjugation of LC3 with PE (LC3-II). Among other autophagy-related (ATG) proteins, it is proposed that, like in yeast, both ATG5 and ATG7 are essential for LC3 conjugation. Using atg5-deficient ( -/- ) and atg7-/- macroph...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2021.1874132

    authors: Vujić N,Bradić I,Goeritzer M,Kuentzel KB,Rainer S,Kratky D,Radović B

    更新日期:2021-01-18 00:00:00

  • Unsaturation, curvature and charge: effects of membrane parameters on PIK3C3/VPS34-containing complexes.

    abstract::Phosphatidylinositol-3-phosphate (PtdIns3P) is essential for generating autophagosomes and regulating endocytic trafficking. Recently, we have shown that the activities of human PIK3C3/VPS34-containing complexes I and II, which synthesize PtdIns3P, are greatly affected by three membrane physicochemical parameters: lip...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2021.1872190

    authors: Ohashi Y,Tremel S,Williams RL

    更新日期:2021-01-15 00:00:00

  • Targeting MCL1 to induce mitophagy is a potential therapeutic strategy for Alzheimer disease.

    abstract::Mitochondrial dysfunction is associated with the occurrence of a variety of neurodegenerative diseases, especially Alzheimer disease (AD). As a mitochondrial quality control process, mitophagy is greatly inhibited in AD; increasing evidence shows that the induction of mitophagy is an effective therapeutic intervention...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1860542

    authors: Cen X,Xu X,Xia H

    更新日期:2020-12-20 00:00:00

  • Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5).

    abstract::Blood-brain barrier (BBB) disruption is a key event in triggering secondary damage to the central nervous system (CNS) under stroke, and is frequently associated with abnormal macroautophagy/autophagy in brain microvascular endothelial cells (BMECs). However, the underlying mechanism of autophagy in maintaining BBB in...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1851897

    authors: Yang Z,Lin P,Chen B,Zhang X,Xiao W,Wu S,Huang C,Feng D,Zhang W,Zhang J

    更新日期:2020-12-07 00:00:00

  • Donor MSCs release apoptotic bodies to improve myocardial infarction via autophagy regulation in recipient cells.

    abstract::Mesenchymal stem cell (MSC) transplantation has been widely applied as a potential therapeutic for multiple diseases. However, the underlying therapeutic mechanisms are not fully understood, especially the paradox between the low survival rate of transplanted cells and the beneficial therapeutic effects generated by t...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1717128

    authors: Liu H,Liu S,Qiu X,Yang X,Bao L,Pu F,Liu X,Li C,Xuan K,Zhou J,Deng Z,Liu S,Jin Y

    更新日期:2020-12-01 00:00:00

  • Identification of the autophagy pathway in a mollusk bivalve, Crassostrea gigas.

    abstract::The Pacific oyster, Crassostrea gigas, is a mollusk bivalve commercially important as a food source. Pacific oysters are subjected to stress and diseases during culture. The autophagy pathway is involved in numerous cellular processes, including responses to starvation, cell death, and microorganism elimination. Autop...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1713643

    authors: Picot S,Faury N,Arzul I,Chollet B,Renault T,Morga B

    更新日期:2020-11-01 00:00:00

  • Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein.

    abstract::KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive. Here, we report that extracellular KRASG12D is essential for pancreatic tumor-ass...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1714209

    authors: Dai E,Han L,Liu J,Xie Y,Kroemer G,Klionsky DJ,Zeh HJ,Kang R,Wang J,Tang D

    更新日期:2020-11-01 00:00:00

  • Glycogen: the missing link in neuronal autophagy?

    abstract::Macroautophagy/autophagy is an intracellular degradative pathway that is often induced as a pro-survival process for cells under stress. A few recent reports establish the role of the glycogen metabolic pathway in neuronal cell survival in conditions such as oxidative stress and hypoxia, and the possible link between ...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1802090

    authors: Onkar A,Sheshadri D,Ganesh S

    更新日期:2020-11-01 00:00:00

  • Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence.

    abstract::Deficiency in decidualization has been widely regarded as an important cause of spontaneous abortion. Generalized decidualization also includes massive infiltration and enrichment of NK cells. However, the underlying mechanism of decidual NK (dNK) cell residence remains largely unknown. Here, we observe that the incre...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1833515

    authors: Lu H,Yang HL,Zhou WJ,Lai ZZ,Qiu XM,Fu Q,Zhao JY,Wang J,Li DJ,Li MQ

    更新日期:2020-11-01 00:00:00

  • NPC-phagy: selective autophagy of the nuclear pore complexes.

    abstract::Selective autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. This process is a specific degradation pathway for a wide variety of substrates including unwanted cytosolic components, such as protein aggregates, damaged and/or superfluous organelles, and pathogens. Howeve...

    journal_title:Autophagy

    pub_type: 社论

    doi:10.1080/15548627.2020.1798199

    authors: Yin Z,Klionsky DJ

    更新日期:2020-10-01 00:00:00

  • The interplay between PRKCI/PKCλ/ι, SQSTM1/p62, and autophagy orchestrates the oxidative metabolic response that drives liver cancer.

    abstract::Hepatocellular carcinoma (HCC) is the consequence of chronic liver damage caused by the excessive generation of reactive oxygen species (ROS). To mitigate the deleterious effects of ROS, cells activate the transcription factor NFE2L2/NRF2, which is constitutively degraded through its partner KEAP1. The inactivation of...

    journal_title:Autophagy

    pub_type: 评论,杂志文章

    doi:10.1080/15548627.2020.1797290

    authors: Moscat J,Diaz-Meco MT

    更新日期:2020-10-01 00:00:00

  • Autophagic degradation of KAT2A/GCN5 promotes directional migration of vascular smooth muscle cells by reducing TUBA/α-tubulin acetylation.

    abstract::Macroautophagy/autophagy, a fundamental process for degradation of macromolecules and organelles, occurs constitutively at a basal level and is upregulated in response to stress. Whether autophagy regulates protein acetylation and microtubule stability in vascular smooth muscle cells (VSMCs) migration, however, remain...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2019.1707488

    authors: Ouyang C,Mu J,Lu Q,Li J,Zhu H,Wang Q,Zou MH,Xie Z

    更新日期:2020-10-01 00:00:00

  • Retromer regulates the lysosomal clearance of MAPT/tau.

    abstract::The macroautophagy/autophagy-lysosome axis enables the clearance and degradation of cytoplasmic components including protein aggregates, damaged organelles and invading pathogens. Protein aggregation and lysosomal system dysfunction in the brain are common features of several late-onset neurological disorders includin...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1821545

    authors: Carosi JM,Hein LK,van den Hurk M,Adams R,Milky B,Singh S,Bardy C,Denton D,Kumar S,Sargeant TJ

    更新日期:2020-09-22 00:00:00

  • The GID ubiquitin ligase complex is a regulator of AMPK activity and organismal lifespan.

    abstract::The AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis by sensing the metabolic status of the cell. AMPK is regulated by phosphorylation and dephosphorylation as a result of changing AMP/ATP levels and by removal of inhibitory ubiquitin residues by USP10. In this context, we identified the GID-c...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2019.1695399

    authors: Liu H,Ding J,Köhnlein K,Urban N,Ori A,Villavicencio-Lorini P,Walentek P,Klotz LO,Hollemann T,Pfirrmann T

    更新日期:2020-09-01 00:00:00

  • C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis.

    abstract::How lysosome and MTORC1 signaling interact remains elusive in terminally differentiated cells. A G4C2 repeat expansion in C9orf72 is the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9ALS-FTD). We previously identified a C9orf72-SMCR8-containing complex. Here we ...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2019.1703353

    authors: Shao Q,Yang M,Liang C,Ma L,Zhang W,Jiang Z,Luo J,Lee JK,Liang C,Chen JF

    更新日期:2020-09-01 00:00:00

  • IRGM Links Autoimmunity to Autophagy.

    abstract::IRGM is a genetic risk factor for several autoimmune diseases. However, the mechanism of IRGM-mediated protection in autoimmunity remains undetermined. The abnormal activation of type I interferon (IFN) response is one of the significant factors in the pathogenesis of several autoimmune diseases. In our recent study, ...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1810920

    authors: Nath P,Jena KK,Mehto S,Chauhan NR,Sahu R,Dhar K,Srinivas K,Chauhan S,Chauhan S

    更新日期:2020-08-19 00:00:00

  • ATM loss disrupts the autophagy-lysosomal pathway.

    abstract::ATM (ataxia telangiectasia mutated) protein is found associated with multiple organelles including synaptic vesicles, endosomes and lysosomes, often in cooperation with ATR (ataxia telangiectasia and Rad3 related). Mutation of the ATM gene results in ataxia-telangiectasia (A-T), an autosomal recessive disorder with de...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1805860

    authors: Cheng A,Tse KH,Chow HM,Gan Y,Song X,Ma F,Qian YXY,She W,Herrup K

    更新日期:2020-08-14 00:00:00

  • Selective autophagy inhibition through disruption of the PIK3C3-containing complex I.

    abstract::The PIK3C3/VPS34-containing phosphatidylinositol 3-kinase (PtdIns3K) initiation complex (complex I) is necessary for macroautophagy/autophagy initiation and is comprised of PIK3R4/VPS15-PIK3C3/VPS34-BECN1-ATG14, while the endosomal trafficking complex (complex II) is necessary for vesicle trafficking and is comprised ...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1786268

    authors: Pavlinov I,Salkovski M,Aldrich LN

    更新日期:2020-08-01 00:00:00

  • RNA-binding protein ZFP36/TTP protects against ferroptosis by regulating autophagy signaling pathway in hepatic stellate cells.

    abstract::Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms remain poorly understood. Here, we show that the RNA-binding protein ZFP36/TTP (ZFP36 ring finger protein) plays a crucial role in regulating ferroptosis in hepatic stellate cells (HSCs). Upon exposure to ferroptosis-indu...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2019.1687985

    authors: Zhang Z,Guo M,Li Y,Shen M,Kong D,Shao J,Ding H,Tan S,Chen A,Zhang F,Zheng S

    更新日期:2020-08-01 00:00:00

  • Regulation and repurposing of nutrient sensing and autophagy in innate immunity.

    abstract::Nutrients not only act as building blocks but also as signaling molecules. Nutrient-availability promotes cell growth and proliferation and suppresses catabolic processes, such as macroautophagy/autophagy. These effects are mediated by checkpoint kinases such as MTOR (mechanistic target of rapamycin kinase), which is ...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1783119

    authors: Sanchez-Garrido J,Shenoy AR

    更新日期:2020-07-05 00:00:00

  • m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7.

    abstract:N:6-methyladenosine (m6A), the most abundant internal modification on mRNAs in eukaryotes, play roles in adipogenesis. However, the underlying mechanism remains largely unclear. Here, we show that m6A plays a critical role in regulating macroautophagy/autophagy and adipogenesis through targeting Atg5 and Atg7. Mechanis...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2019.1659617

    authors: Wang X,Wu R,Liu Y,Zhao Y,Bi Z,Yao Y,Liu Q,Shi H,Wang F,Wang Y

    更新日期:2020-07-01 00:00:00

  • MLKL contributes to Western diet-induced liver injury through inhibiting autophagy.

    abstract::Macroautophagy/autophagy is critical in maintaining cellular functions and homeostasis. Dynamic regulation of autophagy is associated with development of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH); however, the mechanisms involved in the regulation of autophagy in NAFLD/NASH are n...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1760624

    authors: Wu X,Nagy LE

    更新日期:2020-07-01 00:00:00

  • Puncta intended: connecting the dots between autophagy and cell stress networks.

    abstract::Proteome profiling and global protein-interaction approaches have significantly improved our knowledge of the protein interactomes of autophagy and other cellular stress-response pathways. New discoveries regarding protein complexes, interaction partners, interaction domains, and biological roles of players that are p...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1775394

    authors: Ho CJ,Samarasekera G,Rothe K,Xu J,Yang KC,Leung E,Chan M,Jiang X,Gorski SM

    更新日期:2020-06-07 00:00:00

  • The NEDD4-USP13 axis facilitates autophagy via deubiquitinating PIK3C3.

    abstract::Macroautophagy/autophagy, an evolutionarily conserved eukaryotic bioprocess, plays an important role in the bulk degradation of intracellular macromolecules, organelles, and invading pathogens. PIK3C3/VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3) functions as a key protein in autophagy initiation and ...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1743071

    authors: Xie W,Jin S,Cui J

    更新日期:2020-06-01 00:00:00

  • Autophagy and post-ischemic conditioning in retinal ischemia.

    abstract::Retinal ischemia is a major cause of vision loss and a common underlying mechanism associated with diseases, such as diabetic retinopathy and central retinal artery occlusion. We have previously demonstrated the robust neuroprotection in retina induced by post-conditioning (post-C), a brief period of ischemia, 24 h, f...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1767371

    authors: Mathew B,Chennakesavalu M,Sharma M,Torres LA,Stelman CR,Tran S,Patel R,Burg N,Salkovski M,Kadzielawa K,Seiler F,Aldrich LN,Roth S

    更新日期:2020-05-26 00:00:00

  • An integrative multi-omics approach uncovers the regulatory role of CDK7 and CDK4 in autophagy activation induced by silica nanoparticles.

    abstract::Dysfunction of macroautophagy/autophagy has been postulated as a major cellular toxicological response to nanomaterials. It has been reported that excessive autophagy activation, induced by silica nanoparticles (SiNPs), contributes to autophagy dysfunction, whereas little is known how SiNPs trigger autophagy activatio...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1763019

    authors: Ruan C,Wang C,Gong X,Zhang Y,Deng W,Zhou J,Huang D,Wang Z,Zhang Q,Guo A,Lu J,Gao J,Peng D,Xue Y

    更新日期:2020-05-23 00:00:00

  • The functions of Atg8-family proteins in autophagy and cancer: linked or unrelated?

    abstract::The Atg8-family proteins are subdivided into two subfamilies: the GABARAP and LC3 subfamilies. These proteins, which are major players of the autophagy pathway, present a conserved glycine in their C-terminus necessary for their association to the autophagosome membrane. This family of proteins present multiple roles ...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1749367

    authors: Jacquet M,Guittaut M,Fraichard A,Despouy G

    更新日期:2020-04-19 00:00:00

  • The trehalose-6-phosphate phosphatase Tps2 regulates ATG8 transcription and autophagy in Saccharomyces cerevisiae.

    abstract::Macroautophagy/autophagy is an important catabolic process for maintaining cellular homeostasis by adapting to various stress conditions. Autophagy is mediated by a double-membrane autophagosome, which sequesters a portion of cytoplasmic components for delivery to the vacuole. Several autophagy-related (ATG) genes pla...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1746592

    authors: Kim B,Lee Y,Choi H,Huh WK

    更新日期:2020-04-02 00:00:00

  • Localized de novo phospholipid synthesis drives autophagosome biogenesis.

    abstract::During (macro)autophagy, cells form transient organelles, termed autophagosomes, to target a broad spectrum of substrates for degradation critical to cellular and organismal health. Driven by rapid membrane assembly, an initially small vesicle (phagophore) elongates into a large cup-shaped structure to engulf substrat...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1725379

    authors: Schütter M,Graef M

    更新日期:2020-04-01 00:00:00

  • Upregulation of ATG7 attenuates motor neuron dysfunction associated with depletion of TARDBP/TDP-43.

    abstract::A shared neuropathological hallmark in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is nuclear clearance and cytoplasmic aggregation of TARDBP/TDP-43 (TAR DNA binding protein). We previously showed that the ability of TARDBP to repress nonconserved cryptic exons was impaired in brains of patie...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2019.1635379

    authors: Donde A,Sun M,Jeong YH,Wen X,Ling J,Lin S,Braunstein K,Nie S,Wang S,Chen L,Wong PC

    更新日期:2020-04-01 00:00:00

  • Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease.

    abstract::The precise degradation of dysfunctional mitochondria by mitophagy is essential for maintaining neuronal homeostasis. HTT (huntingtin) can interact with numerous other proteins and thereby perform multiple biological functions within the cell. In this study, we investigated the role of HTT during mitophagy and analyze...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1728096

    authors: Franco-Iborra S,Plaza-Zabala A,Montpeyo M,Sebastian D,Vila M,Martinez-Vicente M

    更新日期:2020-02-24 00:00:00

  • Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation.

    abstract::The precise mechanism through which macroautophagy/autophagy affects psoriasis is poorly understood. Here, we found that keratinocyte (KC) autophagy, which was positively correlated with psoriatic severity in patients and mouse models and could be inhibited by mitogen-activated protein kinase (MAPK) family inactivatio...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2020.1725381

    authors: Wang Z,Zhou H,Zheng H,Zhou X,Shen G,Teng X,Liu X,Zhang J,Wei X,Hu Z,Zeng F,Hu Y,Hu J,Wang X,Chen S,Cheng J,Zhang C,Gui Y,Zou S,Hao Y,Zhao Q,Wu W,Zhou Y,Cui K,Huang N,Wei Y,Li W,Li J

    更新日期:2020-02-16 00:00:00

  • Autophagy: a potential key contributor to the therapeutic action of mesenchymal stem cells.

    abstract::Macroautophagy/autophagy occurs at basal levels in all eukaryotic cells and plays an important role in maintaining bio-energetic homeostasis through the control of molecule degradation and organelle turnover. It can be induced by environmental conditions such as starvation, and is deregulated in many diseases includin...

    journal_title:Autophagy

    pub_type: 杂志文章,评审

    doi:10.1080/15548627.2019.1630223

    authors: Ceccariglia S,Cargnoni A,Silini AR,Parolini O

    更新日期:2020-01-01 00:00:00

  • Long noncoding RNA CA7-4 promotes autophagy and apoptosis via sponging MIR877-3P and MIR5680 in high glucose-induced vascular endothelial cells.

    abstract::Vascular endothelial cells (VECs) that form the inner wall of blood vessels can be injured by high glucose-induced autophagy and apoptosis. Although the role of long noncoding RNA in regulating cell fate has received widespread attention, long noncoding RNAs (lncRNAs) that can both regulate autophagy and apoptosis nee...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2019.1598750

    authors: Zhao X,Su L,He X,Zhao B,Miao J

    更新日期:2020-01-01 00:00:00

  • Essential role of autophagy in resource allocation during sexual reproduction.

    abstract::Sexual reproduction is the most common form of reproduction among eukaryotes, which is characterized by a series of massive cellular or tissue renovations. Recent studies have revealed novel functions of autophagy during sexual reproductive processes, ranging from yeast to mammals. In mammals, autophagy is indispensab...

    journal_title:Autophagy

    pub_type: 杂志文章,评审

    doi:10.1080/15548627.2019.1628543

    authors: Gao H,Khawar MB,Li W

    更新日期:2020-01-01 00:00:00

  • Painting a picture of autophagy in Drosophila.

    abstract::Drawing as a way of understanding things better/easier is in human nature, from textbook images through the models and graphical abstracts published in scientific papers to chalk talks during the academic job interview process. As a molecular cell biologist and geneticist, I always find it easier to show a microscopy ...

    journal_title:Autophagy

    pub_type: 评论,社论

    doi:10.1080/15548627.2019.1659624

    authors: Juhász G

    更新日期:2019-11-01 00:00:00

  • HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting.

    abstract::Infection and inflammation are able to induce diet-independent Na+-accumulation without commensurate water retention in afflicted tissues, which favors the pro-inflammatory activation of mouse macrophages and augments their antibacterial and antiparasitic activity. While Na+-boosted host defense against the protozoan ...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2019.1596483

    authors: Neubert P,Weichselbaum A,Reitinger C,Schatz V,Schröder A,Ferdinand JR,Simon M,Bär AL,Brochhausen C,Gerlach RG,Tomiuk S,Hammer K,Wagner S,van Zandbergen G,Binger KJ,Müller DN,Kitada K,Clatworthy MR,Kurts C,Titze J,

    更新日期:2019-11-01 00:00:00

  • Atg14 protects the intestinal epithelium from TNF-triggered villus atrophy.

    abstract::Regulation of intestinal epithelial turnover is a key component of villus maintenance in the intestine. The balance of cell turnover can be perturbed by various extrinsic factors including the cytokine TNF, a cell signaling protein that mediates both proliferative and cytotoxic outcomes. Under conditions of infection ...

    journal_title:Autophagy

    pub_type: 杂志文章

    doi:10.1080/15548627.2019.1596495

    authors: Jung H,Leal-Ekman JS,Lu Q,Stappenbeck TS

    更新日期:2019-11-01 00:00:00

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