解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Alzheimer disease (AD) is usually accompanied by two prominent pathological features, cerebral accumulation of amyloid-β (Aβ) plaques and presence of MAPT/tau neurofibrillary tangles. Dysregulated clearance of Aβ largely contributes to its accumulation and plaque formation in the brain. Macroautophagy/autophagy is a l...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2021.1872187
更新日期:2021-01-19 00:00:00
abstract::Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies low back pain. Overloading-induced cell death, especially endogenous stem cell death, is the leading factor that undermines intrinsic repair and aggravates IDD. Previous research has separately studied the effect of oxygen conc...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2021.1872227
更新日期:2021-01-18 00:00:00
abstract::Thioglycolate-elicited macrophages exhibit abundant conjugation of LC3 with PE (LC3-II). Among other autophagy-related (ATG) proteins, it is proposed that, like in yeast, both ATG5 and ATG7 are essential for LC3 conjugation. Using atg5-deficient ( -/- ) and atg7-/- macroph...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2021.1874132
更新日期:2021-01-18 00:00:00
abstract::Phosphatidylinositol-3-phosphate (PtdIns3P) is essential for generating autophagosomes and regulating endocytic trafficking. Recently, we have shown that the activities of human PIK3C3/VPS34-containing complexes I and II, which synthesize PtdIns3P, are greatly affected by three membrane physicochemical parameters: lip...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2021.1872190
更新日期:2021-01-15 00:00:00
abstract::Mitochondrial dysfunction is associated with the occurrence of a variety of neurodegenerative diseases, especially Alzheimer disease (AD). As a mitochondrial quality control process, mitophagy is greatly inhibited in AD; increasing evidence shows that the induction of mitophagy is an effective therapeutic intervention...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1860542
更新日期:2020-12-20 00:00:00
abstract::Blood-brain barrier (BBB) disruption is a key event in triggering secondary damage to the central nervous system (CNS) under stroke, and is frequently associated with abnormal macroautophagy/autophagy in brain microvascular endothelial cells (BMECs). However, the underlying mechanism of autophagy in maintaining BBB in...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1851897
更新日期:2020-12-07 00:00:00
abstract::Mesenchymal stem cell (MSC) transplantation has been widely applied as a potential therapeutic for multiple diseases. However, the underlying therapeutic mechanisms are not fully understood, especially the paradox between the low survival rate of transplanted cells and the beneficial therapeutic effects generated by t...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1717128
更新日期:2020-12-01 00:00:00
abstract::The Pacific oyster, Crassostrea gigas, is a mollusk bivalve commercially important as a food source. Pacific oysters are subjected to stress and diseases during culture. The autophagy pathway is involved in numerous cellular processes, including responses to starvation, cell death, and microorganism elimination. Autop...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1713643
更新日期:2020-11-01 00:00:00
abstract::KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive. Here, we report that extracellular KRASG12D is essential for pancreatic tumor-ass...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1714209
更新日期:2020-11-01 00:00:00
abstract::Macroautophagy/autophagy is an intracellular degradative pathway that is often induced as a pro-survival process for cells under stress. A few recent reports establish the role of the glycogen metabolic pathway in neuronal cell survival in conditions such as oxidative stress and hypoxia, and the possible link between ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1802090
更新日期:2020-11-01 00:00:00
abstract::Deficiency in decidualization has been widely regarded as an important cause of spontaneous abortion. Generalized decidualization also includes massive infiltration and enrichment of NK cells. However, the underlying mechanism of decidual NK (dNK) cell residence remains largely unknown. Here, we observe that the incre...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1833515
更新日期:2020-11-01 00:00:00
abstract::Selective autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. This process is a specific degradation pathway for a wide variety of substrates including unwanted cytosolic components, such as protein aggregates, damaged and/or superfluous organelles, and pathogens. Howeve...
journal_title:Autophagy
pub_type: 社论
doi:10.1080/15548627.2020.1798199
更新日期:2020-10-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the consequence of chronic liver damage caused by the excessive generation of reactive oxygen species (ROS). To mitigate the deleterious effects of ROS, cells activate the transcription factor NFE2L2/NRF2, which is constitutively degraded through its partner KEAP1. The inactivation of...
journal_title:Autophagy
pub_type: 评论,杂志文章
doi:10.1080/15548627.2020.1797290
更新日期:2020-10-01 00:00:00
abstract::Macroautophagy/autophagy, a fundamental process for degradation of macromolecules and organelles, occurs constitutively at a basal level and is upregulated in response to stress. Whether autophagy regulates protein acetylation and microtubule stability in vascular smooth muscle cells (VSMCs) migration, however, remain...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1707488
更新日期:2020-10-01 00:00:00
abstract::The macroautophagy/autophagy-lysosome axis enables the clearance and degradation of cytoplasmic components including protein aggregates, damaged organelles and invading pathogens. Protein aggregation and lysosomal system dysfunction in the brain are common features of several late-onset neurological disorders includin...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1821545
更新日期:2020-09-22 00:00:00
abstract::The AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis by sensing the metabolic status of the cell. AMPK is regulated by phosphorylation and dephosphorylation as a result of changing AMP/ATP levels and by removal of inhibitory ubiquitin residues by USP10. In this context, we identified the GID-c...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1695399
更新日期:2020-09-01 00:00:00
abstract::How lysosome and MTORC1 signaling interact remains elusive in terminally differentiated cells. A G4C2 repeat expansion in C9orf72 is the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9ALS-FTD). We previously identified a C9orf72-SMCR8-containing complex. Here we ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1703353
更新日期:2020-09-01 00:00:00
abstract::IRGM is a genetic risk factor for several autoimmune diseases. However, the mechanism of IRGM-mediated protection in autoimmunity remains undetermined. The abnormal activation of type I interferon (IFN) response is one of the significant factors in the pathogenesis of several autoimmune diseases. In our recent study, ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1810920
更新日期:2020-08-19 00:00:00
abstract::ATM (ataxia telangiectasia mutated) protein is found associated with multiple organelles including synaptic vesicles, endosomes and lysosomes, often in cooperation with ATR (ataxia telangiectasia and Rad3 related). Mutation of the ATM gene results in ataxia-telangiectasia (A-T), an autosomal recessive disorder with de...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1805860
更新日期:2020-08-14 00:00:00
abstract::The PIK3C3/VPS34-containing phosphatidylinositol 3-kinase (PtdIns3K) initiation complex (complex I) is necessary for macroautophagy/autophagy initiation and is comprised of PIK3R4/VPS15-PIK3C3/VPS34-BECN1-ATG14, while the endosomal trafficking complex (complex II) is necessary for vesicle trafficking and is comprised ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1786268
更新日期:2020-08-01 00:00:00
abstract::Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms remain poorly understood. Here, we show that the RNA-binding protein ZFP36/TTP (ZFP36 ring finger protein) plays a crucial role in regulating ferroptosis in hepatic stellate cells (HSCs). Upon exposure to ferroptosis-indu...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1687985
更新日期:2020-08-01 00:00:00
abstract::Nutrients not only act as building blocks but also as signaling molecules. Nutrient-availability promotes cell growth and proliferation and suppresses catabolic processes, such as macroautophagy/autophagy. These effects are mediated by checkpoint kinases such as MTOR (mechanistic target of rapamycin kinase), which is ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1783119
更新日期:2020-07-05 00:00:00
abstract:N:6-methyladenosine (m6A), the most abundant internal modification on mRNAs in eukaryotes, play roles in adipogenesis. However, the underlying mechanism remains largely unclear. Here, we show that m6A plays a critical role in regulating macroautophagy/autophagy and adipogenesis through targeting Atg5 and Atg7. Mechanis...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1659617
更新日期:2020-07-01 00:00:00
abstract::Macroautophagy/autophagy is critical in maintaining cellular functions and homeostasis. Dynamic regulation of autophagy is associated with development of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH); however, the mechanisms involved in the regulation of autophagy in NAFLD/NASH are n...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1760624
更新日期:2020-07-01 00:00:00
abstract::Proteome profiling and global protein-interaction approaches have significantly improved our knowledge of the protein interactomes of autophagy and other cellular stress-response pathways. New discoveries regarding protein complexes, interaction partners, interaction domains, and biological roles of players that are p...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1775394
更新日期:2020-06-07 00:00:00
abstract::Macroautophagy/autophagy, an evolutionarily conserved eukaryotic bioprocess, plays an important role in the bulk degradation of intracellular macromolecules, organelles, and invading pathogens. PIK3C3/VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3) functions as a key protein in autophagy initiation and ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1743071
更新日期:2020-06-01 00:00:00
abstract::Retinal ischemia is a major cause of vision loss and a common underlying mechanism associated with diseases, such as diabetic retinopathy and central retinal artery occlusion. We have previously demonstrated the robust neuroprotection in retina induced by post-conditioning (post-C), a brief period of ischemia, 24 h, f...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1767371
更新日期:2020-05-26 00:00:00
abstract::Dysfunction of macroautophagy/autophagy has been postulated as a major cellular toxicological response to nanomaterials. It has been reported that excessive autophagy activation, induced by silica nanoparticles (SiNPs), contributes to autophagy dysfunction, whereas little is known how SiNPs trigger autophagy activatio...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1763019
更新日期:2020-05-23 00:00:00
abstract::The Atg8-family proteins are subdivided into two subfamilies: the GABARAP and LC3 subfamilies. These proteins, which are major players of the autophagy pathway, present a conserved glycine in their C-terminus necessary for their association to the autophagosome membrane. This family of proteins present multiple roles ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1749367
更新日期:2020-04-19 00:00:00
abstract::Macroautophagy/autophagy is an important catabolic process for maintaining cellular homeostasis by adapting to various stress conditions. Autophagy is mediated by a double-membrane autophagosome, which sequesters a portion of cytoplasmic components for delivery to the vacuole. Several autophagy-related (ATG) genes pla...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1746592
更新日期:2020-04-02 00:00:00
abstract::During (macro)autophagy, cells form transient organelles, termed autophagosomes, to target a broad spectrum of substrates for degradation critical to cellular and organismal health. Driven by rapid membrane assembly, an initially small vesicle (phagophore) elongates into a large cup-shaped structure to engulf substrat...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1725379
更新日期:2020-04-01 00:00:00
abstract::A shared neuropathological hallmark in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is nuclear clearance and cytoplasmic aggregation of TARDBP/TDP-43 (TAR DNA binding protein). We previously showed that the ability of TARDBP to repress nonconserved cryptic exons was impaired in brains of patie...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1635379
更新日期:2020-04-01 00:00:00
abstract::The precise degradation of dysfunctional mitochondria by mitophagy is essential for maintaining neuronal homeostasis. HTT (huntingtin) can interact with numerous other proteins and thereby perform multiple biological functions within the cell. In this study, we investigated the role of HTT during mitophagy and analyze...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1728096
更新日期:2020-02-24 00:00:00
abstract::The precise mechanism through which macroautophagy/autophagy affects psoriasis is poorly understood. Here, we found that keratinocyte (KC) autophagy, which was positively correlated with psoriatic severity in patients and mouse models and could be inhibited by mitogen-activated protein kinase (MAPK) family inactivatio...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1725381
更新日期:2020-02-16 00:00:00
abstract::Macroautophagy/autophagy occurs at basal levels in all eukaryotic cells and plays an important role in maintaining bio-energetic homeostasis through the control of molecule degradation and organelle turnover. It can be induced by environmental conditions such as starvation, and is deregulated in many diseases includin...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.1080/15548627.2019.1630223
更新日期:2020-01-01 00:00:00
abstract::Vascular endothelial cells (VECs) that form the inner wall of blood vessels can be injured by high glucose-induced autophagy and apoptosis. Although the role of long noncoding RNA in regulating cell fate has received widespread attention, long noncoding RNAs (lncRNAs) that can both regulate autophagy and apoptosis nee...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1598750
更新日期:2020-01-01 00:00:00
abstract::Sexual reproduction is the most common form of reproduction among eukaryotes, which is characterized by a series of massive cellular or tissue renovations. Recent studies have revealed novel functions of autophagy during sexual reproductive processes, ranging from yeast to mammals. In mammals, autophagy is indispensab...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.1080/15548627.2019.1628543
更新日期:2020-01-01 00:00:00
abstract::Drawing as a way of understanding things better/easier is in human nature, from textbook images through the models and graphical abstracts published in scientific papers to chalk talks during the academic job interview process. As a molecular cell biologist and geneticist, I always find it easier to show a microscopy ...
journal_title:Autophagy
pub_type: 评论,社论
doi:10.1080/15548627.2019.1659624
更新日期:2019-11-01 00:00:00
abstract::Infection and inflammation are able to induce diet-independent Na+-accumulation without commensurate water retention in afflicted tissues, which favors the pro-inflammatory activation of mouse macrophages and augments their antibacterial and antiparasitic activity. While Na+-boosted host defense against the protozoan ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1596483
更新日期:2019-11-01 00:00:00
abstract::Regulation of intestinal epithelial turnover is a key component of villus maintenance in the intestine. The balance of cell turnover can be perturbed by various extrinsic factors including the cytokine TNF, a cell signaling protein that mediates both proliferative and cytotoxic outcomes. Under conditions of infection ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1596495
更新日期:2019-11-01 00:00:00