Abstract:
:Shigella, the causative agent of human bacillary dysentery, invades the host cell, rapidly breaking the phagosome and multiplying in the cytosol. Here, we summarize our recent work showing the targeting of the leftover membrane remnants to autophagy together with trapped membrane-associated signaling molecules recruited during the immediate early entry step. We suggest that this mechanism participates in the bacteria-dependent orchestration of the cell response. Moreover, we propose that this signaling node may have relevance as to how the cell interprets endomembrane damage triggered by other stimuli.
journal_name
Autophagyjournal_title
Autophagyauthors
Dupont N,Lafont Fdoi
10.4161/auto.5.8.10218subject
Has Abstractpub_date
2009-11-01 00:00:00pages
1222-3issue
8eissn
1554-8627issn
1554-8635pii
10218journal_volume
5pub_type
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