Abstract:
:Atg8 and its homologs are essential for autophagosome formation in various species. In animal cells, Atg8 homologs have an additional function in clearance of damaged organelles and bacteria, acting as a landmark for selective autophagy. We have recently shown that OATL1, a Rab-GTPase-activating protein (Rab-GAP), is a novel binding partner of Atg8 homologs in mammalian cells, but to our surprise, it is not a substrate of autophagy. Further analysis indicates that OATL1 is involved in the fusion between autophagosomes and lysosomes through its GAP activity and its Atg8 homolog binding activity. Our findings suggest a novel function of Atg8 homologs as a scaffold for signal transduction that regulates autophagosomal maturation.
journal_name
Autophagyjournal_title
Autophagyauthors
Itoh T,Fukuda Mdoi
10.4161/auto.7.9.16178subject
Has Abstractpub_date
2011-09-01 00:00:00pages
1080-1issue
9eissn
1554-8627issn
1554-8635pii
16178journal_volume
7pub_type
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