A possible role of Atg8 homologs as a scaffold for signal transduction.

Abstract:

:Atg8 and its homologs are essential for autophagosome formation in various species. In animal cells, Atg8 homologs have an additional function in clearance of damaged organelles and bacteria, acting as a landmark for selective autophagy. We have recently shown that OATL1, a Rab-GTPase-activating protein (Rab-GAP), is a novel binding partner of Atg8 homologs in mammalian cells, but to our surprise, it is not a substrate of autophagy. Further analysis indicates that OATL1 is involved in the fusion between autophagosomes and lysosomes through its GAP activity and its Atg8 homolog binding activity. Our findings suggest a novel function of Atg8 homologs as a scaffold for signal transduction that regulates autophagosomal maturation.

journal_name

Autophagy

journal_title

Autophagy

authors

Itoh T,Fukuda M

doi

10.4161/auto.7.9.16178

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

1080-1

issue

9

eissn

1554-8627

issn

1554-8635

pii

16178

journal_volume

7

pub_type

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