Abstract:
:Hepatic stellate cell (HSC) activation, the transition from a resident quiescent HSC to a myofibroblastic collagen-producing HSC, is a fundamental feature of liver fibrosis. Autophagy has been implicated in major liver pathologies, such as HCV infection and hepatocarcinoma. However, its role in HSC biology is largely unknown. Recently, we were able to demonstrate that HSC activation is followed by an increased autophagic flux and that its inhibition can partially inhibit the HSC myofibroblastic transition. These results point to autophagy as a possible target in the prevention of HSC activation.
journal_name
Autophagyjournal_title
Autophagyauthors
Thoen LF,Guimarães EL,Grunsven LAdoi
10.4161/auto.8.1.18105subject
Has Abstractpub_date
2012-01-01 00:00:00pages
126-8issue
1eissn
1554-8627issn
1554-8635pii
18105journal_volume
8pub_type
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