Abstract:
:The upregulation of autophagosome formation in response to nutrient deprivation requires significant intracellular membrane rearrangements that are poorly understood. Recent findings have implicated COPII-coated vesicles, well known as ER-Golgi cargo transport carriers, as key players in macroautophagy. The role of COPII vesicles in macroautophagy and how they interact with autophagy-related (Atg) proteins was unknown. In our recent report, we show that during nutrient deprivation, phosphorylation of the membrane-distal surface of the COPII coat subunit Sec24 facilitates the interaction of Sec24 with the Atg machinery (specifically, Atg9) to regulate the abundance of autophagosomes during starvation. Phosphorylation of Sec24 is specifically required for macroautophagy, but not ER-Golgi transport. These findings begin to unravel the unique function of COPII vesicles during starvation-induced macroautophagy.
journal_name
Autophagyjournal_title
Autophagyauthors
Wang J,Davis S,Zhu M,Miller EA,Ferro-Novick Sdoi
10.1080/15548627.2017.1287657subject
Has Abstractpub_date
2017-05-04 00:00:00pages
973-974issue
5eissn
1554-8627issn
1554-8635journal_volume
13pub_type
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