Abstract:
:Loss of the lysosomal chloride transport protein ClC-7 leads to complex phenotypes in mice and man, including osteopetrosis, accumulation of lysosomal storage material, and neurodegeneration. Using novel tissue-specific ClC-7 knockout mice, we have shown that upon loss of ClC-7, lysosomal degradation of endocytosed protein is slowed down and accumulation of autophagosomes occurs.
journal_name
Autophagyjournal_title
Autophagyauthors
Wartosch L,Stauber Tdoi
10.4161/auto.6.1.10590subject
Has Abstractpub_date
2010-01-01 00:00:00pages
158-9issue
1eissn
1554-8627issn
1554-8635pii
10590journal_volume
6pub_type
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