Abstract:
:Several recent reports have demonstrated that autophagy is induced in response to hypoxia in cultured cells. However, the mechanism and consequence of hypoxia-induced autophagy remains unclear as there is no consensus between these studies. In our recent report we show that, in human cancer cells, hypoxia cooperates with growth factor signaling to facilitate a HIF1alpha-driven transcriptional response that promotes autophagy. Here we summarize these findings and set them in context of the findings of other groups, concluding that there are likely multiple routes to different forms of autophagy that serve different purposes downstream of hypoxia, depending upon the degree of stress and cellular context.
journal_name
Autophagyjournal_title
Autophagyauthors
Wilkinson S,Ryan KMdoi
10.4161/auto.5.7.9821subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1068-9issue
7eissn
1554-8627issn
1554-8635pii
9821journal_volume
5pub_type
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