Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila.

abstract：:The elimination of tumor cells by apoptosis is the main mechanism of action of chemotherapeutic drugs used in current treatment protocols of acute lymphoblastic leukemia (ALL). Despite the rapid cytoreduction achieved, serious acute and late complications are frequent, and resistance to chemotherapy develops. During t...

journal_title：Autophagy

authors： Crazzolara R,Bradstock KF,Bendall LJ

更新日期：2009-07-01 00:00:00

abstract：:Autophagy, a catabolic pathway of lysosomal degradation, acts not only as an efficient recycle and survival mechanism during cellular stress, but also as an anti-infective machinery. The human pathogen Staphylococcus aureus (S. aureus) was originally considered solely as an extracellular bacterium, but is now recogniz...

journal_title：Autophagy

authors： Neumann Y,Bruns SA,Rohde M,Prajsnar TK,Foster SJ,Schmitz I

更新日期：2016-11-01 00:00:00

abstract：:Innate immune defense against intracellular pathogens, like Salmonella, relies heavily on the autophagy machinery of the host. This response is studied intensively in epithelial cells, the target of Salmonella during gastrointestinal infections. However, little is known of the role that autophagy plays in macrophages,...

journal_title：Autophagy

authors： Masud S,Prajsnar TK,Torraca V,Lamers GEM,Benning M,Van Der Vaart M,Meijer AH

更新日期：2019-05-01 00:00:00

abstract：:The PIK3C3/VPS34-containing phosphatidylinositol 3-kinase (PtdIns3K) initiation complex (complex I) is necessary for macroautophagy/autophagy initiation and is comprised of PIK3R4/VPS15-PIK3C3/VPS34-BECN1-ATG14, while the endosomal trafficking complex (complex II) is necessary for vesicle trafficking and is comprised ...

journal_title：Autophagy

authors： Pavlinov I,Salkovski M,Aldrich LN

更新日期：2020-08-01 00:00:00

abstract：:The life span of various model organisms can be extended by caloric restriction as well as by autophagy-inducing pharmacological agents. Life span-prolonging effects have also been observed in yeast cells, nematodes and flies upon the overexpression of the deacetylase Sirtuin-1. Intrigued by these observations and by ...

journal_title：Autophagy

authors： Morselli E,Maiuri MC,Markaki M,Megalou E,Pasparaki A,Palikaras K,Criollo A,Galluzzi L,Malik SA,Vitale I,Michaud M,Madeo F,Tavernarakis N,Kroemer G

更新日期：2010-01-01 00:00:00

abstract：:Neurons are highly polarized cells composed of two distinct domains, the axon and the somatodendritic domain. Although AMPA-type glutamate receptors, which mediate fast excitatory neurotransmission in the vertebrate CNS, are preferentially expressed in the somatodendritic domain, the molecular mechanisms underlying su...

journal_title：Autophagy

authors： Matsuda S,Yuzaki M

更新日期：2008-08-01 00:00:00

abstract：:The cell wall skeleton of Mycobacterium bovis Bacillus Calmette-Guerin (BCG/CWS) is an effective antitumor immunotherapy agent. Here, we demonstrate that BCG/CWS has a radiosensitizing effect on colon cancer cells through the induction of autophagic cell death. Exposure of HCT116 colon cancer cells to BCG/CWS before i...

journal_title：Autophagy

authors： Yuk JM,Shin DM,Song KS,Lim K,Kim KH,Lee SH,Kim JM,Lee JS,Paik TH,Kim JS,Jo EK

更新日期：2010-01-01 00:00:00

abstract：:Mitochondria are the primary site of energy production in animal cells. In mitochondria, the flow of electrons through the electron transport chain creates a potential difference across the inner membrane, which is utilized for ATP production. However, due to inherent inefficiencies in electron transport, reactive oxy...

journal_title：Autophagy

authors： Zhang J,Ney PA

更新日期：2010-04-01 00:00:00

abstract：:Drawing as a way of understanding things better/easier is in human nature, from textbook images through the models and graphical abstracts published in scientific papers to chalk talks during the academic job interview process. As a molecular cell biologist and geneticist, I always find it easier to show a microscopy ...

journal_title：Autophagy

authors： Juhász G

更新日期：2019-11-01 00:00:00

abstract：:The Atg8-family proteins are subdivided into two subfamilies: the GABARAP and LC3 subfamilies. These proteins, which are major players of the autophagy pathway, present a conserved glycine in their C-terminus necessary for their association to the autophagosome membrane. This family of proteins present multiple roles ...

journal_title：Autophagy

authors： Jacquet M,Guittaut M,Fraichard A,Despouy G

更新日期：2020-04-19 00:00:00

abstract：:SNCA/α-synuclein aggregation plays a crucial role in synucleinopathies such as Parkinson disease and dementia with Lewy bodies. Aggregating and nonaggregating SNCA species are degraded by the autophagy-lysosomal pathway (ALP). Previously, we have shown that the ALP is not only responsible for SNCA degradation but is a...

journal_title：Autophagy

authors： Poehler AM,Xiang W,Spitzer P,May VE,Meixner H,Rockenstein E,Chutna O,Outeiro TF,Winkler J,Masliah E,Klucken J

更新日期：2014-01-01 00:00:00

abstract：:Although alterations of the macroautophagy/autophagy-lysosome pathway have been observed in cancer for many years, the mechanisms underlying these changes and the importance of autophagic and lysosomal reprogramming by cancer have yet to be well identified. Our recent study demonstrates that oncogenic BRAF signaling p...

journal_title：Autophagy

authors： Li S,Song Y,Quach C,Nemecio D,Liang C

更新日期：2019-10-01 00:00:00

abstract：:The exploration into the roles of autophagy in tumorigenesis, either as tumor suppressor or tumor promoter, has led to a great increase in the knowledge of cancer development, progression and treatment. However, there is currently no consensus on how to manipulate autophagy to improve antitumor effects. In this study,...

journal_title：Autophagy

authors： Chang Y,Lin J,Tsung A

更新日期：2012-12-01 00:00:00

abstract：:Damaged mitochondria are turned over through a process of selective autophagy termed mitophagy. In mitophagy, unhealthy mitochondria are recognized and ubiquitinated by Parkinson disease-linked proteins PINK1 and PARK2. The subsequent recruitment of ubiquitin-binding autophagy receptors leads in turn to the sequestrat...

journal_title：Autophagy

authors： Moore AS,Holzbaur EL

更新日期：2016-10-02 00:00:00

abstract：:Macroautophagy is a major lysosomal degradation pathway for cellular components in eukaryotic cells. Baseline macroautophagy is important for quality control of the cytoplasm in order to avoid the accumulation of cytotoxic products. Its stimulation by various stressful situations, including nutrient starvation, is imp...

journal_title：Autophagy

authors： Tuloup-Minguez V,Greffard A,Codogno P,Botti J

更新日期：2011-01-01 00:00:00

abstract：:The vascular system of plants consists of two conducting tissues, xylem and phloem, which differentiate from procambium cells. Xylem serves as a transporting system for water and signaling molecules and is formed by sequential developmental processes, including cell division/expansion, secondary cell wall deposition, ...

journal_title：Autophagy

authors： Kwon SI,Cho HJ,Park OK

更新日期：2010-11-01 00:00:00

abstract：:microRNAs (miRNAs) are a class of small regulatory RNAs that regulate gene expression at the post-transcriptional level. miRNAs play important roles in the regulation of development, growth, and metastasis of cancer, and in determining the response of tumor cells to anticancer therapy. In recent years, they have also ...

journal_title：Autophagy

authors： Yu Y,Cao L,Yang L,Kang R,Lotze M,Tang D

更新日期：2012-05-01 00:00:00

abstract：:Autophagy acts as an intrinsic defense system against intracellular bacterial survival. Recently, multiple cellular pathways that target intracellular bacterial pathogens to autophagy have been described. These include the Atg5/LC3 pathway, which targets Shigella, the ubiquitin (Ub)-NDP52-LC3 pathway, which targets Gr...

journal_title：Autophagy

authors： Ogawa M,Yoshikawa Y,Mimuro H,Hain T,Chakraborty T,Sasakawa C

更新日期：2011-03-01 00:00:00

abstract：:Hepatic stellate cell (HSC) activation, the transition from a resident quiescent HSC to a myofibroblastic collagen-producing HSC, is a fundamental feature of liver fibrosis. Autophagy has been implicated in major liver pathologies, such as HCV infection and hepatocarcinoma. However, its role in HSC biology is largely ...

journal_title：Autophagy

authors： Thoen LF,Guimarães EL,Grunsven LA

更新日期：2012-01-01 00:00:00

abstract：:Autophagy removes long-lived proteins and damaged organelles and is important for maintaining cellular homeostasis. It can also serve in innate immunity to remove intracellular pathogens. As such, viruses have evolved different mechanisms to subvert this innate immune response. We have recently demonstrated that hepat...

journal_title：Autophagy

authors： Sir D,Liang C,Chen WL,Jung JU,Ou JH

更新日期：2008-08-01 00:00:00

abstract：:LC3 is a widely used marker of autophagosomes in mammalian cells. However, in addition to its autophagosomal localization, GFP-LC3 is often found associated with protein aggregates that are formed in an autophagy-independent manner. In addition, LC3 directly interacts with p62/SQSTM1 (hereafter named p62), a common co...

journal_title：Autophagy

authors： Shvets E,Elazar Z

更新日期：2008-11-01 00:00:00

abstract：:Macroautophagy/autophagy is a catabolic process that is essential for cellular homeostasis. How autophagosomal vesicle forms in a spatio-temporally regulated manner remains elusive. Our recent study revealed that small GTPase, RAB37 (RAB37, member RAS oncogene family), functions as a key organizer of autophagosomal me...

journal_title：Autophagy

authors： Song Y,Shang D,Cheng H,Zhou R

更新日期：2018-01-01 00:00:00

abstract：:Blood-brain barrier (BBB) disruption is a key event in triggering secondary damage to the central nervous system (CNS) under stroke, and is frequently associated with abnormal macroautophagy/autophagy in brain microvascular endothelial cells (BMECs). However, the underlying mechanism of autophagy in maintaining BBB in...

journal_title：Autophagy

authors： Yang Z,Lin P,Chen B,Zhang X,Xiao W,Wu S,Huang C,Feng D,Zhang W,Zhang J

更新日期：2020-12-07 00:00:00

abstract：:Flies expressing the most common Parkinson disease (PD)-related mutation, LRRK2-G2019S, in their dopaminergic neurons show loss of visual function and degeneration of the retina, including mitochondrial abnormalities, apoptosis and autophagy. Since the photoreceptors that degenerate are not dopaminergic, this demonstr...

journal_title：Autophagy

authors： Hindle SJ,Elliott CJ

更新日期：2013-06-01 00:00:00

abstract：:Autophagy is a degradative pathway conserved among eukaryotes. It is a major route for degradation of long-lived proteins and entire organelles, such as peroxisomes. Atg26, a sterol glucosyltransferase, is specifically required for micro- and macropexophagy, but not for starvation-induced bulk autophagy in Pichia past...

journal_title：Autophagy

authors： Cao Y,Klionsky DJ

更新日期：2007-01-01 00:00:00

abstract：:Recent publications link mitophagy mediated by PINK1 and Parkin with cardioprotection and attenuation of inflammation and cell death. The field is in need of methods to monitor mitochondrial turnover in vivo to support the development of new therapies targeting mitochondrial turnover. ...

journal_title：Autophagy

authors： Gottlieb RA,Mentzer RM Jr,Linton PJ

更新日期：2011-12-01 00:00:00

abstract：:Formation of metastases, also known as cancer dissemination, is an important stage of breast cancer (BrCa) development. KISS1 expression is associated with inhibition of metastases development. Recently we have demonstrated that BrCa metastases to the brain exhibit low levels of KISS1 expression at both mRNA and prote...

journal_title：Autophagy

authors： Kaverina N,Borovjagin AV,Kadagidze Z,Baryshnikov A,Baryshnikova M,Malin D,Ghosh D,Shah N,Welch DR,Gabikian P,Karseladze A,Cobbs C,Ulasov IV

更新日期：2017-01-01 00:00:00

abstract：:Oxidative stress-induced granulosa cell (GCs) death represents a common reason for follicular atresia. Follicle-stimulating hormone (FSH) has been shown to prevent GCs from oxidative injury, although the underlying mechanism remains to be elucidated. Here we first report that the suppression of autophagic cell death v...

journal_title：Autophagy

authors： Shen M,Jiang Y,Guan Z,Cao Y,Li L,Liu H,Sun SC

更新日期：2017-08-03 00:00:00

abstract：:We analyzed the cellular and molecular effects of two different histone deacetylase inhibitors (HDACi), MGCD0103 and vorinostat, in combination with GX15-070, a BH3-mimetic, in acute myeloid leukemia (AML) cell lines and primary AML cells, and demonstrated that the combination has a synergistic antileukemia effect. We...

journal_title：Autophagy

authors： Wei Y,Kadia T,Tong W,Zhang M,Jia Y,Yang H,Hu Y,Viallet J,O'Brien S,Garcia-Manero G

更新日期：2010-10-01 00:00:00

abstract：:The highly invasive and chemoresistant phenotype of pancreatic cancer highlights the urgency to identify prognostic biomarkers and novel therapeutic targets. Recently, we observed a significant correlation between shorter survival and loss of the cytoband 18q22.3. Here we investigated genes encoded by this cytoband, a...

journal_title：Autophagy

authors： Giovannetti E,Giaccone G

更新日期：2014-04-01 00:00:00