Spatiotemporal dynamics of autophagy receptors in selective mitophagy.

abstract：:The precise mechanism through which macroautophagy/autophagy affects psoriasis is poorly understood. Here, we found that keratinocyte (KC) autophagy, which was positively correlated with psoriatic severity in patients and mouse models and could be inhibited by mitogen-activated protein kinase (MAPK) family inactivatio...

journal_title：Autophagy

authors： Wang Z,Zhou H,Zheng H,Zhou X,Shen G,Teng X,Liu X,Zhang J,Wei X,Hu Z,Zeng F,Hu Y,Hu J,Wang X,Chen S,Cheng J,Zhang C,Gui Y,Zou S,Hao Y,Zhao Q,Wu W,Zhou Y,Cui K,Huang N,Wei Y,Li W,Li J

更新日期：2020-02-16 00:00:00

abstract：:Autophagy is an evolutionarily conserved catabolic process that involves the engulfment of cytoplasmic contents in a closed double-membrane structure, called the autophagosome, and their subsequent delivery to the vacuole/lysosomes for degradation. Genetic screens in Saccharomyces cerevisiae have identified more than ...

journal_title：Autophagy

authors： Liang Q,Yang P,Tian E,Han J,Zhang H

更新日期：2012-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) that accumulate under oxidative pressure cause severe damage to cellular components, and induce various cellular responses, including apoptosis, programmed necrosis and autophagy, depending on the cellular setting. Various studies have described ROS-induced autophagy, but only a few direc...

journal_title：Autophagy

authors： Eisenberg-Lerner A,Kimchi A

更新日期：2012-03-01 00:00:00

abstract：:Neuroblastoma is the most common extracranial solid tumor in childhood. Despite intense multimodal therapy and many improvements through basic scientific and clinical research, the successful response of advanced-stage patients to chemotherapy remains poor. Autophagy is a cytoprotective mechanism that may help advance...

journal_title：Autophagy

authors： Oehme I,Lodrini M,Brady NR,Witt O

更新日期：2013-12-01 00:00:00

abstract：:Recent publications link mitophagy mediated by PINK1 and Parkin with cardioprotection and attenuation of inflammation and cell death. The field is in need of methods to monitor mitochondrial turnover in vivo to support the development of new therapies targeting mitochondrial turnover. ...

journal_title：Autophagy

authors： Gottlieb RA,Mentzer RM Jr,Linton PJ

更新日期：2011-12-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory disease with severe inflammatory symptoms in the axial skeleton. The cause of ankylosing spondylitis is unknown. TNFAIP3, also named A20, uses ubiquitin-related functions to regulate immune activation, deficiency of which is highly related to autoimmune ...

journal_title：Autophagy

authors： Zhai Y,Lin P,Feng Z,Lu H,Han Q,Chen J,Zhang Y,He Q,Nan G,Luo X,Wang B,Feng F,Liu F,Chen Z,Zhu P

更新日期：2018-01-01 00:00:00

abstract：:The dysregulation of mitochondrial function has been implicated in the pathogenesis of Parkinson disease. Mutations in the parkin, PINK1 and DJ-1 genes all result in recessive parkinsonism. Although the protein products of these genes have not been fully characterized, it has been established that all three contribute...

journal_title：Autophagy

authors： McCoy MK,Cookson MR

更新日期：2011-05-01 00:00:00

abstract：:Autophagy is one of the survival processes of cancer cells, especially in stressful conditions such as starvation, hypoxia and chemotherapeutic agents. However, its roles in tumor survival have not yet been fully elucidated. Here, we found for the first time that JAK2/STAT3 was activated in HeLa cells when they were s...

journal_title：Autophagy

authors： Yoon S,Woo SU,Kang JH,Kim K,Kwon MH,Park S,Shin HJ,Gwak HS,Chwae YJ

更新日期：2010-11-01 00:00:00

abstract：:Science informs art, and art informs science. Both processes involve creativity and imagination, and collaboration between scientists and artists often leads to new insights in both fields. We took advantage of the power of artistic imagery to demonstrate a dynamic cellular process, autophagy. In particular, we depict...

journal_title：Autophagy

authors： Goodsell DS,Klionsky DJ

更新日期：2010-01-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the two most important components of cellular mechanisms for protein degradation. In the present study we investigated the functional relationship of the two systems and the interactional role of p53 in vitro. Our study showed that the...

journal_title：Autophagy

authors： Du Y,Yang D,Li L,Luo G,Li T,Fan X,Wang Q,Zhang X,Wang Y,Le W

更新日期：2009-07-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a major modulator of cellular lipid metabolism and organelle differentiation. To understand whether autophagy is involved in the processes of dysregulated fatty acid oxidation and induced oxidative stress accompanying prostatic carcinogenesis, we characte...

journal_title：Autophagy

authors： Jiang M,Jerome WG,Hayward SW

更新日期：2010-01-01 00:00:00

abstract：:The Atg1/ULK1 complex plays a central role in starvation-induced autophagy, integrating signals from upstream sensors such as MTOR and AMPK and transducing them to the downstream autophagy pathway. Much progress has been made in the last few years in understanding the mechanisms by which the complex is regulated throu...

journal_title：Autophagy

authors： Wong PM,Puente C,Ganley IG,Jiang X

更新日期：2013-02-01 00:00:00

abstract：:Although Beclin 1 and mTOR are considered to be the main molecules to modulate the autophagic process, searching for other autophagy-regulating molecules is still an ongoing challenge to scientists. Here we demonstrated that FoxO1, a forkhead O family protein, is a mediator of autophagy. Upon oxidative stress or serum...

journal_title：Autophagy

authors： Zhao Y,Wang L,Yang J,Zhang P,Ma K,Zhou J,Liao W,Zhu WG

更新日期：2010-10-01 00:00:00

abstract：:The uptake and degradation of cytoplasmic material by vacuolar autophagy in plants has been studied extensively by electron microscopy and shown to be involved in developmental processes such as vacuole formation, deposition of seed storage proteins and senescence, and in the response of plants to nutrient starvation ...

journal_title：Autophagy

authors： Bassham DC,Laporte M,Marty F,Moriyasu Y,Ohsumi Y,Olsen LJ,Yoshimoto K

更新日期：2006-01-01 00:00:00

abstract：:Actin plays indispensable roles in autophagosome biogenesis. Branched actin networks assembled within phagophore membranes are required for generating the autophagosome membrane shape and movement. The ARP2/3 complex and its regulators, such as JMY (junction mediating and regulatory protein, p53 cofactor), translocate...

journal_title：Autophagy

authors： Liu X,Klionsky DJ

更新日期：2019-03-01 00:00:00

abstract：:The life span of various model organisms can be extended by caloric restriction as well as by autophagy-inducing pharmacological agents. Life span-prolonging effects have also been observed in yeast cells, nematodes and flies upon the overexpression of the deacetylase Sirtuin-1. Intrigued by these observations and by ...

journal_title：Autophagy

authors： Morselli E,Maiuri MC,Markaki M,Megalou E,Pasparaki A,Palikaras K,Criollo A,Galluzzi L,Malik SA,Vitale I,Michaud M,Madeo F,Tavernarakis N,Kroemer G

更新日期：2010-01-01 00:00:00

abstract：:T lymphocytes, the master regulators of immunity, have an unusual lifestyle. Equipped with a clonally distributed receptor they remain resting for long periods of time but go into overdrive when encountering antigen. Antigen recognition triggers an activation program that results in massive proliferation, differentiat...

journal_title：Autophagy

authors： Yang Z,Goronzy JJ,Weyand CM

更新日期：2014-02-01 00:00:00

abstract：:Alterations in contractile activity influence the intracellular homeostasis of muscle, which results in adaptations in the performance and the phenotype of this tissue. Denervation is an effective disuse model that functions to change the intracellular environment of muscle leading to a rapid loss in mass, a decrease ...

journal_title：Autophagy

authors： O'Leary MF,Hood DA

更新日期：2009-02-01 00:00:00

abstract：:The cell wall skeleton of Mycobacterium bovis Bacillus Calmette-Guerin (BCG/CWS) is an effective antitumor immunotherapy agent. Here, we demonstrate that BCG/CWS has a radiosensitizing effect on colon cancer cells through the induction of autophagic cell death. Exposure of HCT116 colon cancer cells to BCG/CWS before i...

journal_title：Autophagy

authors： Yuk JM,Shin DM,Song KS,Lim K,Kim KH,Lee SH,Kim JM,Lee JS,Paik TH,Kim JS,Jo EK

更新日期：2010-01-01 00:00:00

abstract：:FTY720, a sphingosine analog, is a novel immunosuppressant currently undergoing multiple clinical trials for the prevention of organ transplant rejection and treatment of various autoimmune diseases. Recent studies indicate an additional cytotoxic effect of FTY720 and its preclinical efficacy in a variety of cancer mo...

journal_title：Autophagy

authors： Zhang N,Qi Y,Wadham C,Wang L,Warren A,Di W,Xia P

更新日期：2010-11-01 00:00:00

abstract：:Complex membrane trafficking events are involved in the regulation of antigen processing and presentation of both endogenous and exogenous antigens. While these processes were believed to involve mainly organelles along the endo/phagocytic and the biosynthetic pathways, recent studies have shown that autophagy also pa...

journal_title：Autophagy

authors： English L,Chemali M,Desjardins M

更新日期：2009-10-01 00:00:00

abstract：:Salinomycin is perhaps the first promising compound that was discovered through high throughput screening in cancer stem cells. This novel agent can selectively eliminate breast and other cancer stem cells, though the mechanism of action remains unclear. In this study, we found that salinomycin induced autophagy in hu...

journal_title：Autophagy

authors： Li T,Su L,Zhong N,Hao X,Zhong D,Singhal S,Liu X

更新日期：2013-07-01 00:00:00

abstract：:ISG15 (ISG15 ubiquitin-like modifier), a ubiquitin-like protein, is one of the major type I IFN (interferon) effector systems. ISG15 can be conjugated to target proteins (ISGylation) via the stepwise action of E1, E2, and E3 enzymes. Conjugated ISG15 can be removed (deISGylated) from target proteins by USP18 (ubiquiti...

journal_title：Autophagy

authors： Xu D,Zhang T,Xiao J,Zhu K,Wei R,Wu Z,Meng H,Li Y,Yuan J

更新日期：2015-04-03 00:00:00

abstract：:Upon completion of cytokinesis, the midbody ring is transported asymmetrically into one of the two daughter cells where it becomes a midbody ring derivative that is degraded by autophagy. In this study we showed that the ubiquitin-binding autophagy receptor SQSTM1/p62 and the interacting adaptor protein WDFY3/ALFY for...

journal_title：Autophagy

authors： Isakson P,Lystad AH,Breen K,Koster G,Stenmark H,Simonsen A

更新日期：2013-12-01 00:00:00

abstract：:The precise degradation of dysfunctional mitochondria by mitophagy is essential for maintaining neuronal homeostasis. HTT (huntingtin) can interact with numerous other proteins and thereby perform multiple biological functions within the cell. In this study, we investigated the role of HTT during mitophagy and analyze...

journal_title：Autophagy

authors： Franco-Iborra S,Plaza-Zabala A,Montpeyo M,Sebastian D,Vila M,Martinez-Vicente M

更新日期：2020-02-24 00:00:00

abstract：:Increasing evidence suggests that misfolded proteins and intracellular aggregates contribute to cardiac disease and heart failure. We wished to determine if autophagic induction by Atg7 is sufficient to reduce misfolded protein and aggregate content in protein misfolding-stressed cardiomyocytes. We used loss- and gain...

journal_title：Autophagy

authors： Pattison JS,Robbins J

更新日期：2011-10-01 00:00:00

abstract：:Ticks are long-lived hematophagous arthropods and have tolerance to starvation. They can survive without food during the host-seeking period for several months to years. To understand how ticks obtain energy over a long period of non-feeding (starvation), we focused on autophagy, a crucial proteolysis system via the l...

journal_title：Autophagy

authors： Umemiya-Shirafuji R,Matsuo T,Liao M,Boldbaatar D,Battur B,Suzuki H,Fujisaki K

更新日期：2010-05-01 00:00:00

abstract：:Deficiency in decidualization has been widely regarded as an important cause of spontaneous abortion. Generalized decidualization also includes massive infiltration and enrichment of NK cells. However, the underlying mechanism of decidual NK (dNK) cell residence remains largely unknown. Here, we observe that the incre...

journal_title：Autophagy

authors： Lu H,Yang HL,Zhou WJ,Lai ZZ,Qiu XM,Fu Q,Zhao JY,Wang J,Li DJ,Li MQ

更新日期：2020-11-01 00:00:00

abstract：:Silver nanoparticles (Ag NPs) are cytotoxic to cancer cells and possess excellent potential as an antitumor agent. A variety of nanoparticles have been shown to induce autophagy, a critical cellular degradation process, and the elevated autophagy in most of these situations promotes cell death. Whether Ag NPs can indu...

journal_title：Autophagy

authors： Lin J,Huang Z,Wu H,Zhou W,Jin P,Wei P,Zhang Y,Zheng F,Zhang J,Xu J,Hu Y,Wang Y,Li Y,Gu N,Wen L

更新日期：2014-01-01 00:00:00

abstract：:UVRAG is a promoter of the autophagy pathway, and its deficiency may fuel the development of cancers. Intriguingly, our recent study has demonstrated that this protein also mediates the repair of damaged DNA and patrols centrosome stability, mechanisms that commonly prevent cancer progression, in a manner independent ...

journal_title：Autophagy

authors： Zhao Z,Ni D,Ghozalli I,Pirooz SD,Ma B,Liang C

更新日期：2012-09-01 00:00:00