DJ-1 regulation of mitochondrial function and autophagy through oxidative stress.

abstract：:Although several oncogenes enhance autophagic flux, the molecular mechanism and consequences of oncogene-induced autophagy remain to be clarified. We have recently shown that expression of oncogenic H-Ras (V12) promotes autophagy through upregulation of Beclin 1 and the BH3-only protein Noxa. H-Ras-expressing cells un...

journal_title：Autophagy

authors： Martin SJ

更新日期：2011-08-01 00:00:00

abstract：:We analyzed the cellular and molecular effects of two different histone deacetylase inhibitors (HDACi), MGCD0103 and vorinostat, in combination with GX15-070, a BH3-mimetic, in acute myeloid leukemia (AML) cell lines and primary AML cells, and demonstrated that the combination has a synergistic antileukemia effect. We...

journal_title：Autophagy

authors： Wei Y,Kadia T,Tong W,Zhang M,Jia Y,Yang H,Hu Y,Viallet J,O'Brien S,Garcia-Manero G

更新日期：2010-10-01 00:00:00

abstract：:As a selective degradation system, chaperone-mediated autophagy (CMA) is essential for maintaining cellular homeostasis and survival under stress conditions. Increasing evidence points to an important role for the dysfunction of CMA in the pathogenesis of Parkinson disease (PD). However, the mechanisms by which CMA re...

journal_title：Autophagy

authors： Wang B,Cai Z,Tao K,Zeng W,Lu F,Yang R,Feng D,Gao G,Yang Q

更新日期：2016-08-02 00:00:00

abstract：:Thioglycolate-elicited macrophages exhibit abundant conjugation of LC3 with PE (LC3-II). Among other autophagy-related (ATG) proteins, it is proposed that, like in yeast, both ATG5 and ATG7 are essential for LC3 conjugation. Using atg5-deficient ( -/- ) and atg7-/- macroph...

journal_title：Autophagy

authors： Vujić N,Bradić I,Goeritzer M,Kuentzel KB,Rainer S,Kratky D,Radović B

更新日期：2021-01-18 00:00:00

abstract：:Shigella, the causative agent of human bacillary dysentery, invades the host cell, rapidly breaking the phagosome and multiplying in the cytosol. Here, we summarize our recent work showing the targeting of the leftover membrane remnants to autophagy together with trapped membrane-associated signaling molecules recruit...

journal_title：Autophagy

authors： Dupont N,Lafont F

更新日期：2009-11-01 00:00:00

abstract：:Macroautophagy/autophagy is critical in maintaining cellular functions and homeostasis. Dynamic regulation of autophagy is associated with development of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH); however, the mechanisms involved in the regulation of autophagy in NAFLD/NASH are n...

journal_title：Autophagy

authors： Wu X,Nagy LE

更新日期：2020-07-01 00:00:00

abstract：:The uptake and degradation of cytoplasmic material by vacuolar autophagy in plants has been studied extensively by electron microscopy and shown to be involved in developmental processes such as vacuole formation, deposition of seed storage proteins and senescence, and in the response of plants to nutrient starvation ...

journal_title：Autophagy

authors： Bassham DC,Laporte M,Marty F,Moriyasu Y,Ohsumi Y,Olsen LJ,Yoshimoto K

更新日期：2006-01-01 00:00:00

abstract：:In a recent paper we addressed the mechanism by which defective autophagy contributes to TARDBP/TDP-43-mediated neurodegenerative disorders. We demonstrated that TARDBP regulates MTORC1-TFEB signaling by targeting RPTOR/raptor, a key component and an adaptor protein of MTORC1. Loss of TARDBP decreased the mRNA stabili...

journal_title：Autophagy

authors： Ying Z,Xia Q,Hao Z,Xu D,Wang M,Wang H,Wang G

更新日期：2016-01-01 00:00:00

abstract：:Here, we present a summary of our recent findings on the (patho-)physiological relevance of PINK1-phosphorylated ubiquitin (p-S65-Ub). Using novel polyclonal antibodies, we find that p-S65-Ub specifically accumulates on damaged mitochondria. Phosphorylation of ubiquitin on serine 65 depends on the activity of PINK1 an...

journal_title：Autophagy

authors： Fiesel FC,Springer W

更新日期：2015-11-02 00:00:00

abstract：:The RNA replication complexes of small positive-strand RNA viruses such as poliovirus are known to form on the surfaces of membranous vesicles in the cytoplasm of infected mammalian cells. These membranes resemble cellular autophagosomes in their double-membraned morphology, cytoplasmic lumen, lipid-rich composition a...

journal_title：Autophagy

authors： Taylor MP,Kirkegaard K

更新日期：2008-04-01 00:00:00

abstract：:Formation of metastases, also known as cancer dissemination, is an important stage of breast cancer (BrCa) development. KISS1 expression is associated with inhibition of metastases development. Recently we have demonstrated that BrCa metastases to the brain exhibit low levels of KISS1 expression at both mRNA and prote...

journal_title：Autophagy

authors： Kaverina N,Borovjagin AV,Kadagidze Z,Baryshnikov A,Baryshnikova M,Malin D,Ghosh D,Shah N,Welch DR,Gabikian P,Karseladze A,Cobbs C,Ulasov IV

更新日期：2017-01-01 00:00:00

abstract：:Phagocytosis and macroautophagy/autophagy are 2 processes involved in lysosome-mediated clearance of extracellular and intracellular components, respectively. Recent studies have identified the recruitment of the autophagic protein LC3 during phagocytosis of apoptotic corpses in what is now called LC3-associated phago...

journal_title：Autophagy

authors： Jenzer C,Simionato E,Largeau C,Scarcelli V,Lefebvre C,Legouis R

更新日期：2019-02-01 00:00:00

abstract：:Loss-of-function mutations in PARK2/PARKIN and PINK1 cause early-onset autosomal recessive Parkinson disease (PD). The cytosolic E3 ubiquitin-protein ligase PARK2 cooperates with the mitochondrial kinase PINK1 to maintain mitochondrial quality. A loss of mitochondrial transmembrane potential (ΔΨ) leads to the PINK1-de...

journal_title：Autophagy

authors： Bertolin G,Ferrando-Miguel R,Jacoupy M,Traver S,Grenier K,Greene AW,Dauphin A,Waharte F,Bayot A,Salamero J,Lombès A,Bulteau AL,Fon EA,Brice A,Corti O

更新日期：2013-11-01 00:00:00

abstract：:Macroautophagy/autophagy is a catabolic process that is essential for cellular homeostasis. How autophagosomal vesicle forms in a spatio-temporally regulated manner remains elusive. Our recent study revealed that small GTPase, RAB37 (RAB37, member RAS oncogene family), functions as a key organizer of autophagosomal me...

journal_title：Autophagy

authors： Song Y,Shang D,Cheng H,Zhou R

更新日期：2018-01-01 00:00:00

abstract：:Autophagy is a highly conserved intracellular degradation system, and recently was shown to display circadian rhythms in mice. The mechanisms underlying circadian regulation of autophagy, however, are still unclear. Here, we observed that numbers of autophagosomes and autolysosomes exhibit daily rhythms in the zebrafi...

journal_title：Autophagy

authors： Huang G,Zhang F,Ye Q,Wang H

更新日期：2016-08-02 00:00:00

abstract：:Although the treatments of malignant glioma include surgery, radiotherapy and chemotherapy by oral drug administration, the prognosis of patients with glioma remains very poor. We developed a polyethylene glycol-dipalmitoylphosphatidyle- thanoiamine (mPEG-DPPE) calcium phosphate nanoparticles (NPs) injectable thermore...

journal_title：Autophagy

authors： Ding L,Wang Q,Shen M,Sun Y,Zhang X,Huang C,Chen J,Li R,Duan Y

更新日期：2017-07-03 00:00:00

abstract：:Autophagy is a degradation pathway for the turnover of dysfunctional organelles or aggregated proteins in cells. Extracellular accumulation of beta-amyloid peptide has been reported to be a major cause of Alzheimer disease (AD) and large numbers of autophagic vacuoles accumulate in the brain of AD patient. However, ho...

journal_title：Autophagy

authors： Hung SY,Huang WP,Liou HC,Fu WM

更新日期：2009-05-01 00:00:00

abstract：:A shared neuropathological hallmark in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is nuclear clearance and cytoplasmic aggregation of TARDBP/TDP-43 (TAR DNA binding protein). We previously showed that the ability of TARDBP to repress nonconserved cryptic exons was impaired in brains of patie...

journal_title：Autophagy

authors： Donde A,Sun M,Jeong YH,Wen X,Ling J,Lin S,Braunstein K,Nie S,Wang S,Chen L,Wong PC

更新日期：2020-04-01 00:00:00

abstract：:Autophagy and microRNA (miRNA) are important regulators during cancer cell tumorigenesis. Impaired autophagy and high expression of the oncogenic microRNA MIR224 are prevalent in hepatocellular carcinoma (HCC); however, the relationship between the 2 phenomena remains elusive. In this study, we are the first to reveal...

journal_title：Autophagy

authors： Lan SH,Wu SY,Zuchini R,Lin XZ,Su IJ,Tsai TF,Lin YJ,Wu CT,Liu HS

更新日期：2014-09-01 00:00:00

abstract：:Autophagy is a catabolic process employed by eukaryotes to degrade and recycle intracellular components. When this pathway is induced by starvation conditions, part of the cytoplasm and organelles are sequestered into double-membrane vesicles called autophagosomes, and delivered into the lysosome/vacuole for degradati...

journal_title：Autophagy

authors： Monastyrska I,Reggiori F,Klionsky DJ

更新日期：2008-10-01 00:00:00

abstract：:KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive. Here, we report that extracellular KRASG12D is essential for pancreatic tumor-ass...

journal_title：Autophagy

authors： Dai E,Han L,Liu J,Xie Y,Kroemer G,Klionsky DJ,Zeh HJ,Kang R,Wang J,Tang D

更新日期：2020-11-01 00:00:00

abstract：:Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies low back pain. Overloading-induced cell death, especially endogenous stem cell death, is the leading factor that undermines intrinsic repair and aggravates IDD. Previous research has separately studied the effect of oxygen conc...

journal_title：Autophagy

authors： He R,Wang Z,Cui M,Liu S,Wu W,Chen M,Wu Y,Qu Y,Lin H,Chen S,Wang B,Shao Z

更新日期：2021-01-18 00:00:00

abstract：:Macroautophagy/autophagy dysfunction is associated with many neurodegenerative diseases. TFEB (transcription factor EB), an important molecule that regulates lysosomal and autophagy function, is regarded as a potential target for treating some neurodegenerative diseases. However, the relationship between autophagy dys...

journal_title：Autophagy

authors： Ye B,Wang Q,Hu H,Shen Y,Fan C,Chen P,Ma Y,Wu H,Xiang M

更新日期：2019-06-01 00:00:00

abstract：:microRNAs (miRNAs) are a class of small regulatory RNAs that regulate gene expression at the post-transcriptional level. miRNAs play important roles in the regulation of development, growth, and metastasis of cancer, and in determining the response of tumor cells to anticancer therapy. In recent years, they have also ...

journal_title：Autophagy

authors： Yu Y,Cao L,Yang L,Kang R,Lotze M,Tang D

更新日期：2012-05-01 00:00:00

abstract：:Under stress conditions cells activate different response pathways which result in cell survival or apoptosis depending on: (1) the nature of the insults, (2) the type, if acute or chronic stress, and (3) how long the stress persists. Generally, autophagy is induced early to sustain cell survival and inhibit cell deat...

journal_title：Autophagy

authors： Corazzari M,Fimia GM,Piacentini M

更新日期：2012-08-01 00:00:00

abstract：:In the world of pathogen-host cell interactions, the autophagic pathway has been recently described as a component of the innate immune response against intracellular microorganisms. Indeed, some bacterial survival mechanisms are hampered when this process is activated. Mycobacterium tuberculosis infection of macropha...

journal_title：Autophagy

authors： Colombo MI,Gutierrez MG,Romano PS

更新日期：2006-07-01 00:00:00

abstract：:We detail here a protocol using tandem-tagged mCherry-EGFP-LC3 (C-G-LC3) to quantify autophagic flux in single cells by ratiometric flow cytometry and to isolate subpopulations of cells based on their relative levels of autophagic flux. This robust and sensitive method measures autophagic flux rather than autophagosom...

journal_title：Autophagy

authors： Gump JM,Thorburn A

更新日期：2014-07-01 00:00:00

abstract：:Science informs art, and art informs science. Both processes involve creativity and imagination, and collaboration between scientists and artists often leads to new insights in both fields. We took advantage of the power of artistic imagery to demonstrate a dynamic cellular process, autophagy. In particular, we depict...

journal_title：Autophagy

authors： Goodsell DS,Klionsky DJ

更新日期：2010-01-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the two most important components of cellular mechanisms for protein degradation. In the present study we investigated the functional relationship of the two systems and the interactional role of p53 in vitro. Our study showed that the...

journal_title：Autophagy

authors： Du Y,Yang D,Li L,Luo G,Li T,Fan X,Wang Q,Zhang X,Wang Y,Le W

更新日期：2009-07-01 00:00:00

abstract：:Multiple stress pathways result in the induction of autophagy and apoptosis. Current methods (e.g., protein gel blot, microscopy) do not offer quantitative single-cell resolution, thus making it difficult to discern if these pathways are mutually exclusive or, in some situations, cooperative in executing cell death. W...

journal_title：Autophagy

authors： de la Calle C,Joubert PE,Law HK,Hasan M,Albert ML

更新日期：2011-09-01 00:00:00