Abstract:
:Although several oncogenes enhance autophagic flux, the molecular mechanism and consequences of oncogene-induced autophagy remain to be clarified. We have recently shown that expression of oncogenic H-Ras (V12) promotes autophagy through upregulation of Beclin 1 and the BH3-only protein Noxa. H-Ras-expressing cells undergo autophagic cell death as a result of Noxa-mediated displacement of Mcl-1 and Bcl-xL from Beclin 1. Oncogenic H-Ras-induced death is attenuated through knockdown of BECLIN 1, ATG5, or ATG7, or through overexpression of Mcl-1, Bcl-2, Bcl-xL and their close relatives. These observations suggest that high-intensity oncogene activation may be selected against by promoting excessive autophagy, leading to cell death. Consequently, such oncogenes may select for cells with a reduced capacity for autophagy, either through loss of a BECLIN 1 allele or through upregulation of negative regulators of Beclin 1, such as Bcl-2 family members.
journal_name
Autophagyjournal_title
Autophagyauthors
Martin SJdoi
10.4161/auto.7.8.15821subject
Has Abstractpub_date
2011-08-01 00:00:00pages
922-3issue
8eissn
1554-8627issn
1554-8635pii
15821journal_volume
7pub_type
杂志文章相关文献
Autophagy文献大全abstract::In a series of studies into the fate of endothelial cells exposed to non-enzymatically glycated collagen I, a model of cytotoxic molecules relevant to diabetic vasculopathy, we demonstrate that cells either undergo apoptosis or become prematurely senescent despite relatively spared telomeres and telomerase activity. O...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5904
更新日期:2008-05-01 00:00:00
abstract::Microglia are innate immune cells in the central nervous system (CNS), that supplies neurons with key factors for executing autophagosomal/lysosomal functions. Macroautophagy/autophagy is a cellular catabolic process that maintains cell balance in response to stress-related stimulation. Abnormal autophagy occurs with ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2018.1522467
更新日期:2019-03-01 00:00:00
abstract::Single microRNA (miRNA) can regulate expression of several or multiple principal targets in a specific microenvironment. In different cellular contexts, the same miRNA may exhibit diverse functions, depending on the repertoire and stoichiometry of its direct mRNA targets. For instance, in breast cancer, microRNA-10b (...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.11.17371
更新日期:2011-11-01 00:00:00
abstract::Macroautophagy/autophagy is the main intracellular catabolic pathway in neurons that eliminates misfolded proteins, aggregates and damaged organelles associated with ageing and neurodegeneration. Autophagy is regulated by both MTOR-dependent and -independent pathways. There is increasing evidence that autophagy is com...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1385674
更新日期:2018-01-01 00:00:00
abstract::Autophagy genes were first identified in the yeast system and some of their mammalian orthologues have also been characterized. Increasing lines of evidence indicate that various intracellular proteins, including G proteins, mammalian target of rapamycin (mTor) and Pl3K/Akt/PKB, of transmembrane signaling pathways are...
journal_title:Autophagy
pub_type: 评论,杂志文章,评审
doi:10.4161/auto.3427
更新日期:2007-01-01 00:00:00
abstract::IRGM is a genetic risk factor for several autoimmune diseases. However, the mechanism of IRGM-mediated protection in autoimmunity remains undetermined. The abnormal activation of type I interferon (IFN) response is one of the significant factors in the pathogenesis of several autoimmune diseases. In our recent study, ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1810920
更新日期:2020-08-19 00:00:00
abstract::microRNAs (miRNAs) are a class of small regulatory RNAs that regulate gene expression at the post-transcriptional level. miRNAs play important roles in the regulation of development, growth, and metastasis of cancer, and in determining the response of tumor cells to anticancer therapy. In recent years, they have also ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.20053
更新日期:2012-05-01 00:00:00
abstract::Blood-brain barrier (BBB) disruption is a key event in triggering secondary damage to the central nervous system (CNS) under stroke, and is frequently associated with abnormal macroautophagy/autophagy in brain microvascular endothelial cells (BMECs). However, the underlying mechanism of autophagy in maintaining BBB in...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1851897
更新日期:2020-12-07 00:00:00
abstract::In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update the...
journal_title:Autophagy
pub_type: 指南,杂志文章
doi:10.4161/auto.19496
更新日期:2012-04-01 00:00:00
abstract::Flies expressing the most common Parkinson disease (PD)-related mutation, LRRK2-G2019S, in their dopaminergic neurons show loss of visual function and degeneration of the retina, including mitochondrial abnormalities, apoptosis and autophagy. Since the photoreceptors that degenerate are not dopaminergic, this demonstr...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.24397
更新日期:2013-06-01 00:00:00
abstract::Autophagy is a lysosome-directed membrane trafficking event for the degradation of cytoplasmic components, including organelles. The past few years have seen a great advance in our understanding of the cellular machinery of autophagosome biogenesis, the hallmark of autophagy. However, our global understanding of autop...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6496
更新日期:2008-08-01 00:00:00
abstract::Most autophagy-related (Atg) proteins are assembled at the phagophore assembly site or pre-autophagosomal structure (PAS), which is a potential site for vesicle formation during vegetative or starvation conditions. To understand the initial step of vesicle formation, it is important to know how Atg proteins are recrui...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6375
更新日期:2008-07-01 00:00:00
abstract::Macroautophagy/autophagy is a fundamental intracellular degradation process with multiple roles in immunity, including direct elimination of intracellular microorganisms via 'xenophagy.' In this review, we summarize studies from the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans that highlig...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.1080/15548627.2017.1389824
更新日期:2018-01-01 00:00:00
abstract::Inhibition of the autophagic pathway has recently revealed promising results in increasing pro-death activity of multiple cancer therapeutics. Here, we discuss our findings regarding the autophagy-blocking and anti-neoplastic effects of a synthetic sphingosine analog, FTY720, in mantle cell lymphoma (MCL). We also emp...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19050
更新日期:2012-03-01 00:00:00
abstract::ULK1 (unc51-like autophagy activating kinase 1) is a serine/threonine kinase that plays a key role in regulating macroautophagy/autophagy induction in response to amino acid starvation. Despite the recent progress in understanding ULK1 functions, the molecular mechanism by which ULK1 regulates the induction of autopha...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1422851
更新日期:2018-01-01 00:00:00
abstract::Drawing as a way of understanding things better/easier is in human nature, from textbook images through the models and graphical abstracts published in scientific papers to chalk talks during the academic job interview process. As a molecular cell biologist and geneticist, I always find it easier to show a microscopy ...
journal_title:Autophagy
pub_type: 评论,社论
doi:10.1080/15548627.2019.1659624
更新日期:2019-11-01 00:00:00
abstract::During (macro)autophagy, cells form transient organelles, termed autophagosomes, to target a broad spectrum of substrates for degradation critical to cellular and organismal health. Driven by rapid membrane assembly, an initially small vesicle (phagophore) elongates into a large cup-shaped structure to engulf substrat...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1725379
更新日期:2020-04-01 00:00:00
abstract::The lack of a rapid and quantitative autophagy assay has substantially hindered the development and implementation of autophagy-targeting therapies for a variety of human diseases. To address this critical issue, we developed a novel autophagy assay using the newly developed Cyto-ID fluorescence dye. We first verified...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2015.1017181
更新日期:2015-01-01 00:00:00
abstract::We describe a protocol for rapid and efficient enrichment of autophagosomes from various tissues of the GFP-LC3 mouse. In order to increase the number of autophagosomes, we block autophagy flux in the GFP-LC3 mouse tissue with a single intraperitoneal injection of leupeptin 4-5 h before tissue harvesting. We homogeniz...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2018.1539591
更新日期:2019-02-01 00:00:00
abstract::FTY720, a sphingosine analog, is a novel immunosuppressant currently undergoing multiple clinical trials for the prevention of organ transplant rejection and treatment of various autoimmune diseases. Recent studies indicate an additional cytotoxic effect of FTY720 and its preclinical efficacy in a variety of cancer mo...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.8.13614
更新日期:2010-11-01 00:00:00
abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons. As with other age-dependent neurodegenerative disorders, ALS is linked to the presence of misfolded proteins that may perturb several intracellular mechanisms and trigger neu...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.7.13042
更新日期:2010-10-01 00:00:00
abstract::Rapamycin is an inhibitor of mTOR, a key component of the mTORC1 complex that controls the growth and survival of cells in response to growth factors, nutrients, energy balance and stresses. The downstream targets of mTORC1 include ribosome biogenesis, transcription, translation and macroautophagy. Recently it was pro...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6059
更新日期:2008-05-01 00:00:00
abstract::Numerous studies have reported that inhibition of MTOR (mechanistic target of rapamycin kinase) clearly reduces Alzheimer disease neuropathological hallmarks in mouse models. This has resulted in calls for the use of the MTOR inhibitor rapamycin for the treatment of dementia in humans. Unfortunately, intervention with...
journal_title:Autophagy
pub_type: 评论,杂志文章
doi:10.1080/15548627.2019.1615823
更新日期:2019-08-01 00:00:00
abstract::The macroautophagy/autophagy-lysosome axis enables the clearance and degradation of cytoplasmic components including protein aggregates, damaged organelles and invading pathogens. Protein aggregation and lysosomal system dysfunction in the brain are common features of several late-onset neurological disorders includin...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1821545
更新日期:2020-09-22 00:00:00
abstract::In a recent study, we reported in vivo evidence of early and sustained alterations of autophagy markers in a novel knock-in mouse model of Huntington disease (HD). The novel model is derived from selective breeding of HdhQ150 knock-in mice to generate mice with ~200 CAG/polyglutamine repeats (HdhQ200). HdhQ200 knockin...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.8.13617
更新日期:2010-11-01 00:00:00
abstract::Autophagy is a conserved membrane traffic pathway that equips eukaryotic cells to capture cytoplasmic components within a double-membrane vacuole, or autophagosome, for delivery to lysosomes. Although best known as a mechanism to survive starvation, autophagy is now recognized to combat infection by a variety of micro...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.2831
更新日期:2006-07-01 00:00:00
abstract::Selective autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. This process is a specific degradation pathway for a wide variety of substrates including unwanted cytosolic components, such as protein aggregates, damaged and/or superfluous organelles, and pathogens. Howeve...
journal_title:Autophagy
pub_type: 社论
doi:10.1080/15548627.2020.1798199
更新日期:2020-10-01 00:00:00
abstract::DBI/ACBP (diazepam binding protein, acyl-CoA binding protein) participates in the regulation of fatty acid metabolism when it is localized within cells, whereas outside of cells it acts as a diazepam-binding protein. Recent results indicate that many different mammalian cell types release DBI/ACBP upon in vitro or in ...
journal_title:Autophagy
pub_type: 评论,杂志文章
doi:10.1080/15548627.2019.1662585
更新日期:2019-11-01 00:00:00
abstract::Macroautophagy (referred to as autophagy) is an evolutionarily conserved, bulk-destruction process in eukaryotes. During this process, the cytoplasm containing long-lived proteins and organelles is engulfed into double-membrane autophagosomes, and ultimately undergoes enzymatic degradation within lysosomes. Autophagy ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.8.13508
更新日期:2010-11-01 00:00:00
abstract::A shared neuropathological hallmark in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is nuclear clearance and cytoplasmic aggregation of TARDBP/TDP-43 (TAR DNA binding protein). We previously showed that the ability of TARDBP to repress nonconserved cryptic exons was impaired in brains of patie...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1635379
更新日期:2020-04-01 00:00:00