Abstract:
:Autophagy is a conserved membrane traffic pathway that equips eukaryotic cells to capture cytoplasmic components within a double-membrane vacuole, or autophagosome, for delivery to lysosomes. Although best known as a mechanism to survive starvation, autophagy is now recognized to combat infection by a variety of microbes.(1-3) Not surprisingly, to establish a replication niche in host cells, some intracellular pathogens have acquired mechanisms either to evade or subvert the autophagic pathway. Because they are amenable to genetic manipulation, these microbes can be exploited as experimental tools to investigate the contribution of autophagy to immunity. Here we discuss the mouse macrophage response to L. pneumophila, the facultative intracellular bacterium responsible for an acute form of pneumonia, Legionnaire's disease.
journal_name
Autophagyjournal_title
Autophagyauthors
Dubuisson JF,Swanson MSdoi
10.4161/auto.2831subject
Has Abstractpub_date
2006-07-01 00:00:00pages
179-82issue
3eissn
1554-8627issn
1554-8635pii
2831journal_volume
2pub_type
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