Abstract:
:UVRAG is a promoter of the autophagy pathway, and its deficiency may fuel the development of cancers. Intriguingly, our recent study has demonstrated that this protein also mediates the repair of damaged DNA and patrols centrosome stability, mechanisms that commonly prevent cancer progression, in a manner independent of its role in autophagy signaling. Given the central role of UVRAG in genomic stability and autophagic cleaning, it is speculated that UVRAG is a bona fide genome protector and that the decrease in UVRAG seen in some cancers may render these cells vulnerable to chromosomal damage, making UVRAG an appealing target for cancer therapy.
journal_name
Autophagyjournal_title
Autophagyauthors
Zhao Z,Ni D,Ghozalli I,Pirooz SD,Ma B,Liang Cdoi
10.4161/auto.21035subject
Has Abstractpub_date
2012-09-01 00:00:00pages
1392-3issue
9eissn
1554-8627issn
1554-8635pii
21035journal_volume
8pub_type
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