Abstract:
:Autophagy and apoptosis are 2 fundamental biological mechanisms that may cooperate or be antagonistic, although both are involved in deciding the fate of cells in physiological or pathological conditions. These 2 mechanisms coexist simultaneously in cells and share common upstream signals and stimuli. Autophagy and apoptosis play pivotal roles in cancer development. Autophagy plays a key function in maintaining tumor cell survival by providing energy during unfavorable metabolic conditions through its recycling mechanism, and supporting the high energy requirement for metabolism and growth. This review focuses on gastrointestinal stromal tumors and cell death through autophagy and apoptosis, taking into account the involvement of both of these processes in tumor development and growth and as mechanisms of drug resistance. We also focus on the crosstalk between autophagy and apoptosis as an emerging field with major implications for the development of novel therapeutic options.
journal_name
Autophagyjournal_title
Autophagyauthors
Ravegnini G,Sammarini G,Nannini M,Pantaleo MA,Biasco G,Hrelia P,Angelini Sdoi
10.1080/15548627.2016.1256522subject
Has Abstractpub_date
2017-03-04 00:00:00pages
452-463issue
3eissn
1554-8627issn
1554-8635journal_volume
13pub_type
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