Abstract:
:Macroautophagy ("autophagy") is regulated by the same insulin-amino acid-mTOR signaling pathway that controls protein synthesis. Although the literature does not so far include any direct studies confirming this, we expect autophagy to increase during insulin resistance. We discuss the possibility that this may be a useful mechanism for eliminating damaged mitochondria and other cell structures to prevent cell death.
journal_name
Autophagyjournal_title
Autophagyauthors
Meijer AJ,Codogno Pdoi
10.4161/auto.4449subject
Has Abstractpub_date
2007-09-01 00:00:00pages
523-6issue
5eissn
1554-8627issn
1554-8635pii
4449journal_volume
3pub_type
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