Autophagy mediates phosphatidylserine exposure and phagosome degradation during apoptosis through specific functions of GABARAP/LGG-1 and LC3/LGG-2.

abstract：:Based on my reading, and on my own experience, I have come to realize that people learn in different ways, and this can include the use of different media. This is one reason I have worked with various artists to portray the topic of autophagy through paintings, music and dance. Indeed, comments from members of the au...

journal_title：Autophagy

authors： Klionsky DJ

更新日期：2019-09-01 00:00:00

abstract：:The ubiquitin-like conjugation reactions, ATG8/microtubule-associated protein 1 light chain 3/MAP1LC3 (LC3) to phosphatidylethanolamine (PE) and ATG12 to ATG5, are biochemical hallmarks for autophagy, a cellular process that degrades bulk cellular proteins and organelles. The two conjugation reactions share the same E...

journal_title：Autophagy

authors： Shao Y,Gao Z,Feldman T,Jiang X

更新日期：2007-01-01 00:00:00

abstract：:Autophagy is a catabolic process employed by eukaryotes to degrade and recycle intracellular components. When this pathway is induced by starvation conditions, part of the cytoplasm and organelles are sequestered into double-membrane vesicles called autophagosomes, and delivered into the lysosome/vacuole for degradati...

journal_title：Autophagy

authors： Monastyrska I,Reggiori F,Klionsky DJ

更新日期：2008-10-01 00:00:00

abstract：:Macroautophagy is induced under various stresses to remove cytotoxic materials, including misfolded proteins and their aggregates. These protein cargoes are collected by specific autophagic receptors such as SQSTM1/p62 (sequestosome 1) and delivered to phagophores for lysosomal degradation. To date, little is known ab...

journal_title：Autophagy

authors： Lee DH,Kim D,Kim ST,Jeong S,Kim JL,Shim SM,Heo AJ,Song X,Guo ZS,Bartlett DL,Oh SC,Lee J,Saito Y,Kim BY,Kwon YT,Lee YJ

更新日期：2018-01-01 00:00:00

abstract：:The extensive autophagic-lysosomal pathology in Alzheimer disease (AD) brain has revealed a major defect: in the proteolytic clearance of autophagy substrates. Autophagy failure contributes on several levels to AD pathogenesis and has become an important therapeutic target for AD and other neurodegenerative diseases. ...

journal_title：Autophagy

authors： Yang DS,Stavrides P,Mohan PS,Kaushik S,Kumar A,Ohno M,Schmidt SD,Wesson DW,Bandyopadhyay U,Jiang Y,Pawlik M,Peterhoff CM,Yang AJ,Wilson DA,St George-Hyslop P,Westaway D,Mathews PM,Levy E,Cuervo AM,Nixon RA

更新日期：2011-07-01 00:00:00

abstract：:Formation of the autophagosome is likely the most complex step of macroautophagy, and indeed it is the morphological and functional hallmark of this process; accordingly, it is critical to understand the corresponding molecular mechanism. Atg8 is the only known autophagy-related (Atg) protein required for autophagosom...

journal_title：Autophagy

authors： Nair U,Yen WL,Mari M,Cao Y,Xie Z,Baba M,Reggiori F,Klionsky DJ

更新日期：2012-05-01 00:00:00

abstract：:The highly invasive and chemoresistant phenotype of pancreatic cancer highlights the urgency to identify prognostic biomarkers and novel therapeutic targets. Recently, we observed a significant correlation between shorter survival and loss of the cytoband 18q22.3. Here we investigated genes encoded by this cytoband, a...

journal_title：Autophagy

authors： Giovannetti E,Giaccone G

更新日期：2014-04-01 00:00:00

abstract：:Mitochondrial morphological and structural changes play a role in several cellular processes, including apoptosis. We recently reported that mitochondrial elongation is also critical to sustain cell viability during macroautophagy. During macroautophagy unopposed mitochondrial fusion leads to organelle elongation both...

journal_title：Autophagy

authors： Gomes LC,Scorrano L

更新日期：2011-10-01 00:00:00

abstract：:Autophagy plays critical roles in plant responses to stress. In contrast to the wealth of information concerning the core process of plant autophagosome assembly, our understanding of the regulation of autophagy is limited. In this study, we demonstrated that transcription factor HsfA1a played a critical role in tomat...

journal_title：Autophagy

authors： Wang Y,Cai S,Yin L,Shi K,Xia X,Zhou Y,Yu J,Zhou J

更新日期：2015-11-02 00:00:00

abstract：:Two primary forms of autophagy have been identified in the field of cancer therapy based on their apparent functions in the tumor cell; these are the cytoprotective form that could, in theory, be inhibited for the purpose of sensitization to radiation and chemotherapeutic drugs and the "cytotoxic" form that either med...

journal_title：Autophagy

authors： Gewirtz DA

更新日期：2013-09-01 00:00:00

abstract：:To maintain proper cellular homeostasis, the magnitude of autophagy activity has to be finely tuned in response to environmental changes. Many aspects of autophagy regulation have been extensively studied: pathways integrating signals through the master regulators TORC1 and PKA lead to multiple post-translational modi...

journal_title：Autophagy

authors： Bernard A,Klionsky DJ

更新日期：2015-04-03 00:00:00

abstract：:Dysfunction of macroautophagy/autophagy has been postulated as a major cellular toxicological response to nanomaterials. It has been reported that excessive autophagy activation, induced by silica nanoparticles (SiNPs), contributes to autophagy dysfunction, whereas little is known how SiNPs trigger autophagy activatio...

journal_title：Autophagy

authors： Ruan C,Wang C,Gong X,Zhang Y,Deng W,Zhou J,Huang D,Wang Z,Zhang Q,Guo A,Lu J,Gao J,Peng D,Xue Y

更新日期：2020-05-23 00:00:00

abstract：:Macroautophagy (referred to as autophagy) is an evolutionarily conserved, bulk-destruction process in eukaryotes. During this process, the cytoplasm containing long-lived proteins and organelles is engulfed into double-membrane autophagosomes, and ultimately undergoes enzymatic degradation within lysosomes. Autophagy ...

journal_title：Autophagy

authors： Wang L,Dong Z,Huang B,Zhao B,Wang H,Zhao J,Kung H,Zhang S,Miao J

更新日期：2010-11-01 00:00:00

abstract：:A major side effect of the powerful immunosuppressive drug cyclosporine (CsA) is the development of a chronic nephrotoxicity whose mechanisms are not fully understood. Recent data suggest that tubular cells play a central role in the pathogenesis of chronic nephropathies. We have shown that CsA is responsible for endo...

journal_title：Autophagy

authors： Pallet N,Bouvier N,Legendre C,Gilleron J,Codogno P,Beaune P,Thervet E,Anglicheau D

更新日期：2008-08-01 00:00:00

abstract：N:6-methyladenosine (m6A), the most abundant internal modification on mRNAs in eukaryotes, play roles in adipogenesis. However, the underlying mechanism remains largely unclear. Here, we show that m6A plays a critical role in regulating macroautophagy/autophagy and adipogenesis through targeting Atg5 and Atg7. Mechanis...

journal_title：Autophagy

authors： Wang X,Wu R,Liu Y,Zhao Y,Bi Z,Yao Y,Liu Q,Shi H,Wang F,Wang Y

更新日期：2020-07-01 00:00:00

abstract：:Here, we present a summary of our recent findings on the (patho-)physiological relevance of PINK1-phosphorylated ubiquitin (p-S65-Ub). Using novel polyclonal antibodies, we find that p-S65-Ub specifically accumulates on damaged mitochondria. Phosphorylation of ubiquitin on serine 65 depends on the activity of PINK1 an...

journal_title：Autophagy

authors： Fiesel FC,Springer W

更新日期：2015-11-02 00:00:00

abstract：:The role of autophagy in the degradation of aggregate-prone proteins has been well established. As a result, autophagy upregulation has become an attractive therapeutic strategy for the treatment of proteinopathies, a group of diseases caused by the accumulation of mutant misfolded proteins. We have previously shown t...

journal_title：Autophagy

authors： Menzies FM,Rubinsztein DC

更新日期：2010-02-01 00:00:00

abstract：:UVRAG is a promoter of the autophagy pathway, and its deficiency may fuel the development of cancers. Intriguingly, our recent study has demonstrated that this protein also mediates the repair of damaged DNA and patrols centrosome stability, mechanisms that commonly prevent cancer progression, in a manner independent ...

journal_title：Autophagy

authors： Zhao Z,Ni D,Ghozalli I,Pirooz SD,Ma B,Liang C

更新日期：2012-09-01 00:00:00

abstract：:Autophagy resembles a recycling process in which proteins, organelles, or regions of the cytoplasm are enveloped and degraded. We have found that two of the central autophagy proteins, MAP1LC3 (microtubule-associated protein 1 light chain 3, also described as LC3) and UVRAG (UV radiation resistance associated/UV radia...

journal_title：Autophagy

authors： Mir SU,Schwarze SR,Jin L,Zhang J,Friend W,Miriyala S,St Clair D,Craven RJ

更新日期：2013-10-01 00:00:00

abstract：:ULK1 and ATG13 assemble with RB1CC1/FIP200 and ATG101 to form a macroautophagy (hereafter autophagy) induction (ULK1) complex in higher eukaryotes. The yeast counterpart, the Atg1 complex, is comprised of Atg1 and Atg13 (ULK1 and ATG13 homologs), Atg17 (a proposed functional homolog of RB1CC1), and either the Atg101 s...

journal_title：Autophagy

authors： Popelka H,Klionsky DJ

更新日期：2015-11-02 00:00:00

abstract：:The etiological agent for anthrax is Bacillus anthracis, which produces lethal toxin (LT) that exerts a myriad of effects on many immune cells. In our previous study, it was demonstrated that LT and protective antigen (PA) induce autophagy in mammalian cells. Preliminary results suggest that autophagy may function as ...

journal_title：Autophagy

authors： Tan YK,Vu HA,Kusuma CM,Wu A

更新日期：2009-07-01 00:00:00

abstract：:The best-characterized process of autophagy is macroautophagy. Many an article or talk has started with the phrase "...macroautophagy, hereafter referred to as autophagy." This one will be different because we are going to learn more about the person most responsible for increasing our understanding of chaperone-media...

journal_title：Autophagy

authors： Dice JF

更新日期：2009-11-01 00:00:00

abstract：:A wide variety of genetic, pharmacological and nutrient manipulations that extend lifespan in model organisms do so in a manner dependent upon increased autophagic flux. However, our recent findings suggest that when mitochondrial membrane integrity is compromised, macroautophagy/autophagy can be detrimental. In C. el...

journal_title：Autophagy

authors： Zhou B,Soukas AA

更新日期：2019-10-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory disease with severe inflammatory symptoms in the axial skeleton. The cause of ankylosing spondylitis is unknown. TNFAIP3, also named A20, uses ubiquitin-related functions to regulate immune activation, deficiency of which is highly related to autoimmune ...

journal_title：Autophagy

authors： Zhai Y,Lin P,Feng Z,Lu H,Han Q,Chen J,Zhang Y,He Q,Nan G,Luo X,Wang B,Feng F,Liu F,Chen Z,Zhu P

更新日期：2018-01-01 00:00:00

abstract：:Nutrients not only act as building blocks but also as signaling molecules. Nutrient-availability promotes cell growth and proliferation and suppresses catabolic processes, such as macroautophagy/autophagy. These effects are mediated by checkpoint kinases such as MTOR (mechanistic target of rapamycin kinase), which is ...

journal_title：Autophagy

authors： Sanchez-Garrido J,Shenoy AR

更新日期：2020-07-05 00:00:00

abstract：:To facilitate the purification of rat liver autophagosomes, isolated rat hepatocytes are first incubated for 2 h at 37°C with vinblastine, which induces autophagosome accumulation by blocking the fusion of these organelles with endosomes and lysosomes. The hepatocytes are then electrodisrupted and homogenized, and the...

journal_title：Autophagy

authors： Seglen PO,Brinchmann MF

更新日期：2010-05-01 00:00:00

abstract：:Tumor hypoxia underlies treatment failure and yields more aggressive and metastatic cancer phenotypes. Although therapeutically targeting these hypoxic environments has been proposed for many years, to date no approaches have shown the therapeutic value to gain regulatory approval. Here, we demonstrated that a novel h...

journal_title：Autophagy

authors： Liu XW,Cai TY,Zhu H,Cao J,Su Y,Hu YZ,He QJ,Yang B

更新日期：2014-01-01 00:00:00

abstract：:Actin plays indispensable roles in autophagosome biogenesis. Branched actin networks assembled within phagophore membranes are required for generating the autophagosome membrane shape and movement. The ARP2/3 complex and its regulators, such as JMY (junction mediating and regulatory protein, p53 cofactor), translocate...

journal_title：Autophagy

authors： Liu X,Klionsky DJ

更新日期：2019-03-01 00:00:00

abstract：:DBI/ACBP (diazepam binding protein, acyl-CoA binding protein) participates in the regulation of fatty acid metabolism when it is localized within cells, whereas outside of cells it acts as a diazepam-binding protein. Recent results indicate that many different mammalian cell types release DBI/ACBP upon in vitro or in ...

journal_title：Autophagy

authors： Bravo-San Pedro JM,Sica V,Martins I,Anagnostopoulos G,Maiuri C,Kroemer G

更新日期：2019-11-01 00:00:00

abstract：:Increasing evidence suggests that misfolded proteins and intracellular aggregates contribute to cardiac disease and heart failure. We wished to determine if autophagic induction by Atg7 is sufficient to reduce misfolded protein and aggregate content in protein misfolding-stressed cardiomyocytes. We used loss- and gain...

journal_title：Autophagy

authors： Pattison JS,Robbins J

更新日期：2011-10-01 00:00:00