Implications of autophagy in anthrax pathogenicity.

abstract：:Vascular endothelial cells (VECs) that form the inner wall of blood vessels can be injured by high glucose-induced autophagy and apoptosis. Although the role of long noncoding RNA in regulating cell fate has received widespread attention, long noncoding RNAs (lncRNAs) that can both regulate autophagy and apoptosis nee...

journal_title：Autophagy

authors： Zhao X,Su L,He X,Zhao B,Miao J

更新日期：2020-01-01 00:00:00

abstract：:The conserved target of rapamycin (TOR) kinase is a central regulator of cell growth in response to nutrient availability. TOR forms 2 structurally and functionally distinct complexes, TORC1 and TORC2, and negatively regulates autophagy via TORC1. Here we demonstrate TOR also operates independently through the TORC2 s...

journal_title：Autophagy

authors： Vlahakis A,Powers T

更新日期：2014-01-01 00:00:00

abstract：:Mitochondrial quality control is an essential process required to maintain cellular homeostasis and functions. Mutations of PINK1 and PRKN/PARK2 contribute to the risk of Parkinson disease. Our recent findings indicate that depletion of Pink1 and Prkn promotes pancreatic tumorigenesis in KRAS-driven engineered mouse m...

journal_title：Autophagy

authors： Kang R,Xie Y,Zeh HJ,Klionsky DJ,Tang D

更新日期：2019-01-01 00:00:00

abstract：:ATM (ataxia telangiectasia mutated) protein is found associated with multiple organelles including synaptic vesicles, endosomes and lysosomes, often in cooperation with ATR (ataxia telangiectasia and Rad3 related). Mutation of the ATM gene results in ataxia-telangiectasia (A-T), an autosomal recessive disorder with de...

journal_title：Autophagy

authors： Cheng A,Tse KH,Chow HM,Gan Y,Song X,Ma F,Qian YXY,She W,Herrup K

更新日期：2020-08-14 00:00:00

abstract：:Macroautophagy/autophagy is a dynamic and inducible catabolic process that responds to a variety of hormonal and environmental cues. Recent studies highlight the interplay of this central pathway in a variety of pathophysiological diseases. Although defective autophagy is implicated in melanocyte proliferation and pig...

journal_title：Autophagy

authors： Ramkumar A,Murthy D,Raja DA,Singh A,Krishnan A,Khanna S,Vats A,Thukral L,Sharma P,Sivasubbu S,Rani R,Natarajan VT,Gokhale RS

更新日期：2017-08-03 00:00:00

abstract：:A hallmark of macroautophagy is the formation of autophagosomes, double-membrane vesicles that enwrap cellular components destined for lysosomal degradation. We examined autophagosomal protein dynamics under various inducing stimuli using a comprehensive mass spectrometry-based proteomics approach in combination with ...

journal_title：Autophagy

authors： Becker AC,Bunkenborg J,Eisenberg T,Harder LM,Schroeder S,Madeo F,Andersen JS,Dengjel J

更新日期：2012-06-01 00:00:00

abstract：:Science informs art, and art informs science. Both processes involve creativity and imagination, and collaboration between scientists and artists often leads to new insights in both fields. We took advantage of the power of artistic imagery to demonstrate a dynamic cellular process, autophagy. In particular, we depict...

journal_title：Autophagy

authors： Goodsell DS,Klionsky DJ

更新日期：2010-01-01 00:00:00

abstract：:Some key questions being examined in the field of autophagy concern the origin of the membrane that forms the sequestering vesicle, the function of the related machinery, including the identification of new components and binding partners of previously identified autophagy-related proteins and the mechanism of autopha...

journal_title：Autophagy

authors： Vellai T,Klionsky DJ

更新日期：2010-01-01 00:00:00

abstract：:When no supply of environmental nutrients is available, cells induce autophagy, thereby generating a source of emergency metabolic substrates and energy to maintain the basal cellular activity needed for survival. This autophagy response to starvation has been well characterized in various multicellular organisms, inc...

journal_title：Autophagy

authors： Kang C,Avery L

更新日期：2009-05-01 00:00:00

abstract：:A steady increase in life expectancy has resulted in an equivalent increase in elderly patients who are more susceptible to diseases than young patients. In a recent study, we found that in both in vitro and in vivo models of ischemia/reperfusion (I/R), a loss of ATG4B is causatively associated with the increased sens...

journal_title：Autophagy

authors： Wang JH,Behrns KE,Leeuwenburgh C,Kim JS

更新日期：2012-01-01 00:00:00

abstract：:The relationship between macroautophagy/autophagy and miRNA in regulating cancer cell motility is not clearly delineated. Here, we found that induction of BECN1-dependent or -independent autophagy decreased ubiquitin-binding proteins SQSTM1/p62 and CALCOCO2/NDP52. Downregulation of SQSTM1 (but not CALCOCO2) led to a d...

journal_title：Autophagy

authors： Liao CC,Ho MY,Liang SM,Liang CM

更新日期：2018-01-01 00:00:00

abstract：:Alzheimer disease (AD) is usually accompanied by two prominent pathological features, cerebral accumulation of amyloid-β (Aβ) plaques and presence of MAPT/tau neurofibrillary tangles. Dysregulated clearance of Aβ largely contributes to its accumulation and plaque formation in the brain. Macroautophagy/autophagy is a l...

journal_title：Autophagy

authors： Wani A,Al Rihani SB,Sharma A,Weadick B,Govindarajan R,Khan SU,Sharma PR,Dogra A,Nandi U,Reddy CN,Bharate SS,Singh G,Bharate SB,Vishwakarma RA,Kaddoumi A,Kumar A

更新日期：2021-01-19 00:00:00

abstract：:Autophagy is a conserved homeostatic process in which cytoplasmic contents are degraded and recycled. Two ubiquitin-like conjugation pathways are required for the generation of autophagosomes, and ATG5 is necessary for both of these processes. Studies of mice deficient in ATG5 reveal a key role for autophagy in T lymp...

journal_title：Autophagy

authors： Conway KL,Kuballa P,Khor B,Zhang M,Shi HN,Virgin HW,Xavier RJ

更新日期：2013-04-01 00:00:00

abstract：:Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase compl...

journal_title：Autophagy

authors： Birgisdottir ÅB,Mouilleron S,Bhujabal Z,Wirth M,Sjøttem E,Evjen G,Zhang W,Lee R,O'Reilly N,Tooze SA,Lamark T,Johansen T

更新日期：2019-08-01 00:00:00

abstract：:DBI/ACBP (diazepam binding protein, acyl-CoA binding protein) participates in the regulation of fatty acid metabolism when it is localized within cells, whereas outside of cells it acts as a diazepam-binding protein. Recent results indicate that many different mammalian cell types release DBI/ACBP upon in vitro or in ...

journal_title：Autophagy

authors： Bravo-San Pedro JM,Sica V,Martins I,Anagnostopoulos G,Maiuri C,Kroemer G

更新日期：2019-11-01 00:00:00

abstract：:microRNAs (miRNAs) are a class of small regulatory RNAs that regulate gene expression at the post-transcriptional level. miRNAs play important roles in the regulation of development, growth, and metastasis of cancer, and in determining the response of tumor cells to anticancer therapy. In recent years, they have also ...

journal_title：Autophagy

authors： Yu Y,Cao L,Yang L,Kang R,Lotze M,Tang D

更新日期：2012-05-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of upper and lower motor neurons. As with other age-dependent neurodegenerative disorders, ALS is linked to the presence of misfolded proteins that may perturb several intracellular mechanisms and trigger neu...

journal_title：Autophagy

authors： Crippa V,Carra S,Rusmini P,Sau D,Bolzoni E,Bendotti C,De Biasi S,Poletti A

更新日期：2010-10-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) often metastasizes to the brain, but identifying which patients will develop brain metastases (BM) is difficult. Macroautophagy/autophagy is critical for cancer initiation and progression. We hypothesized that genetic variants of autophagy-related genes may affect brain metastases (B...

journal_title：Autophagy

authors： Li QX,Zhou X,Huang TT,Tang Y,Liu B,Peng P,Sun L,Wang YH,Yuan XL

更新日期：2017-06-03 00:00:00

abstract：:The N-terminal amino acid of a protein is an essential determinant of ubiquitination and subsequent proteasomal degradation in the N-end rule pathway. Using para-chloroamphetamine (PCA), a specific inhibitor of the arginylation branch of the pathway (Arg/N-end rule pathway), we identified that blocking the Arg/N-end r...

journal_title：Autophagy

authors： Jiang Y,Lee J,Lee JH,Lee JW,Kim JH,Choi WH,Yoo YD,Cha-Molstad H,Kim BY,Kwon YT,Noh SA,Kim KP,Lee MJ

更新日期：2016-11-01 00:00:00

abstract：:Macroautophagy/autophagy is emerging as an important process in adult muscle stem cells functions: it regulates metabolic reprogramming during activation from a quiescent state, maintains stemness and prevents senescence. We now show that autophagy is specifically required for neonatal myogenesis and muscle developmen...

journal_title：Autophagy

authors： Zecchini S,Giovarelli M,Perrotta C,Morisi F,Touvier T,Di Renzo I,Moscheni C,Bassi MT,Cervia D,Sandri M,Clementi E,De Palma C

更新日期：2019-01-01 00:00:00

abstract：:In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea cycle and CPS1 are only present in the liver and, to a minor extent, in the kidney. To address the possibility that SIRT5 is involved i...

journal_title：Autophagy

authors： Polletta L,Vernucci E,Carnevale I,Arcangeli T,Rotili D,Palmerio S,Steegborn C,Nowak T,Schutkowski M,Pellegrini L,Sansone L,Villanova L,Runci A,Pucci B,Morgante E,Fini M,Mai A,Russo MA,Tafani M

更新日期：2015-01-01 00:00:00

abstract：:The precise degradation of dysfunctional mitochondria by mitophagy is essential for maintaining neuronal homeostasis. HTT (huntingtin) can interact with numerous other proteins and thereby perform multiple biological functions within the cell. In this study, we investigated the role of HTT during mitophagy and analyze...

journal_title：Autophagy

authors： Franco-Iborra S,Plaza-Zabala A,Montpeyo M,Sebastian D,Vila M,Martinez-Vicente M

更新日期：2020-02-24 00:00:00

abstract：:The Atg8-family proteins are subdivided into two subfamilies: the GABARAP and LC3 subfamilies. These proteins, which are major players of the autophagy pathway, present a conserved glycine in their C-terminus necessary for their association to the autophagosome membrane. This family of proteins present multiple roles ...

journal_title：Autophagy

authors： Jacquet M,Guittaut M,Fraichard A,Despouy G

更新日期：2020-04-19 00:00:00

abstract：:Understanding of the mechanism for myeloid differentiation provides important insights into the hematopoietic developmental processes. By using an ESC-derived myeloid progenitor cell model, we found that CSF2/GM-CSF triggered macrophage differentiation and activation of the MTOR signaling pathway. Activation or inhibi...

journal_title：Autophagy

authors： Zhang M,Liu F,Zhou P,Wang Q,Xu C,Li Y,Bian L,Liu Y,Zhou J,Wang F,Yao Y,Fang Y,Li D

更新日期：2019-07-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a procedure that has applications in the selective eradication of neoplasia where sites of malignant lesions are clearly delineated. It is a two-step process whereby cells are first sensitized to light and then photoirradiated. This results in the formation of singlet molecular oxygen and...

journal_title：Autophagy

authors： Reiners JJ Jr,Agostinis P,Berg K,Oleinick NL,Kessel D

更新日期：2010-01-01 00:00:00

abstract：:The European autophagy consortium Driving next-generation autophagy researchers towards translation (DRIVE) held its kick-off meeting in Groningen on the 14th and 15th of June 2018. This Marie Skłodowska-Curie Early Training Network was approved under the European Union's Horizon 2020 Research and Innovation Program a...

journal_title：Autophagy

authors： Kraft C,Boya P,Codogno P,Elazar Z,Eskelinen EL,Farrés J,Kirkin V,Jungbluth H,Martinez A,Pless O,Primard C,Proikas-Cezanne T,Simonsen A,Reggiori F

更新日期：2019-02-01 00:00:00

abstract：:One of the main unanswered questions regarding the early steps of macroautophagy/autophagy is the mechanism of membrane-modeling events required for autophagosome formation. Three independent studies have recently revealed an actin cytoskeleton involvement in this process, providing significant details regarding the r...

journal_title：Autophagy

authors： Zientara-Rytter K,Subramani S

更新日期：2016-12-01 00:00:00

abstract：:SPHK1 (sphingosine kinase 1), a regulator of sphingolipid metabolites, plays a causal role in the development of hepatocellular carcinoma (HCC) through augmenting HCC invasion and metastasis. However, the mechanism by which SPHK1 signaling promotes invasion and metastasis in HCC remains to be clarified. Here, we repor...

journal_title：Autophagy

authors： Liu H,Ma Y,He HW,Zhao WL,Shao RG

更新日期：2017-05-04 00:00:00

abstract：:Autophagosome formation is a complex cellular process, which requires major membrane rearrangements leading to the creation of a relatively large double-membrane vesicle that directs its contents to the lysosome for degradation. Although various membrane compartments have been identified as sources for autophagosomal ...

journal_title：Autophagy

authors： Longatti A,Tooze SA

更新日期：2012-11-01 00:00:00

abstract：:Autophagy helps to maintain cellular homeostasis by removing misfolded proteins and damaged organelles, and generally acts as a cytoprotective mechanism for neuronal survival. Here we showed that mice deficient in the Vici syndrome gene Epg5, which is required for autophagosome maturation, show accumulation of ubiquit...

journal_title：Autophagy

authors： Miao G,Zhao YG,Zhao H,Ji C,Sun H,Chen Y,Zhang H

更新日期：2016-12-01 00:00:00