Friend or food: different cues to the autophagosomal proteome.

abstract：:To study mitochondrial protein age dynamics, we targeted a time-sensitive fluorescent protein, MitoTimer, to the mitochondrial matrix. Mitochondrial age was revealed by the integrated portions of young (green) and old (red) MitoTimer protein. Mitochondrial protein age was dependent on turnover rates as pulsed synthesi...

journal_title：Autophagy

authors： Ferree AW,Trudeau K,Zik E,Benador IY,Twig G,Gottlieb RA,Shirihai OS

更新日期：2013-11-01 00:00:00

abstract：:Blood-brain barrier (BBB) disruption is a key event in triggering secondary damage to the central nervous system (CNS) under stroke, and is frequently associated with abnormal macroautophagy/autophagy in brain microvascular endothelial cells (BMECs). However, the underlying mechanism of autophagy in maintaining BBB in...

journal_title：Autophagy

authors： Yang Z,Lin P,Chen B,Zhang X,Xiao W,Wu S,Huang C,Feng D,Zhang W,Zhang J

更新日期：2020-12-07 00:00:00

abstract：:Tumor hypoxia underlies treatment failure and yields more aggressive and metastatic cancer phenotypes. Although therapeutically targeting these hypoxic environments has been proposed for many years, to date no approaches have shown the therapeutic value to gain regulatory approval. Here, we demonstrated that a novel h...

journal_title：Autophagy

authors： Liu XW,Cai TY,Zhu H,Cao J,Su Y,Hu YZ,He QJ,Yang B

更新日期：2014-01-01 00:00:00

abstract：:In humans, loss of TBC1D20 (TBC1 domain family, member 20) protein function causes Warburg Micro syndrome 4 (WARBM4), an autosomal recessive disorder characterized by congenital eye, brain, and genital abnormalities. TBC1D20-deficient mice exhibit ocular abnormalities and male infertility. TBC1D20 is a ubiquitously ex...

journal_title：Autophagy

authors： Sidjanin DJ,Park AK,Ronchetti A,Martins J,Jackson WT

更新日期：2016-10-02 00:00:00

abstract：:Autophagy is a process of bulk protein degradation and organelle turnover, and is a current therapeutic target in several diseases. The present study aimed to clarify the significance of myocardial autophagy of patients with dilated cardiomyopathy (DCM). Left ventricular endomyocardial biopsy was performed in 250 cons...

journal_title：Autophagy

authors： Saito T,Asai K,Sato S,Hayashi M,Adachi A,Sasaki Y,Takano H,Mizuno K,Shimizu W

更新日期：2016-01-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by a chromosomal t(15;17) translocation that fuses the gene encoding the promyelocytic leukemia protein (PML) to that encoding retinoic acid receptor alpha (RARA). The product of this genetic aberration, the PML/RARA fusion protein, is highly oncogenic and supports m...

journal_title：Autophagy

authors： Bøe SO,Simonsen A

更新日期：2010-10-01 00:00:00

abstract：:Autophagy is an evolutionarily conserved catabolic process that involves the engulfment of cytoplasmic contents in a closed double-membrane structure, called the autophagosome, and their subsequent delivery to the vacuole/lysosomes for degradation. Genetic screens in Saccharomyces cerevisiae have identified more than ...

journal_title：Autophagy

authors： Liang Q,Yang P,Tian E,Han J,Zhang H

更新日期：2012-10-01 00:00:00

abstract：:Mutations in the ER-associated VAPB/ALS8 protein cause amyotrophic lateral sclerosis and spinal muscular atrophy. Previous studies have argued that ER stress may underlie the demise of neurons. We find that loss of VAP proteins (VAPs) leads to an accumulation of aberrant lysosomes and impairs lysosomal degradation. VA...

journal_title：Autophagy

authors： Mao D,Lin G,Tepe B,Zuo Z,Tan KL,Senturk M,Zhang S,Arenkiel BR,Sardiello M,Bellen HJ

更新日期：2019-07-01 00:00:00

abstract：:Salinomycin is perhaps the first promising compound that was discovered through high throughput screening in cancer stem cells. This novel agent can selectively eliminate breast and other cancer stem cells, though the mechanism of action remains unclear. In this study, we found that salinomycin induced autophagy in hu...

journal_title：Autophagy

authors： Li T,Su L,Zhong N,Hao X,Zhong D,Singhal S,Liu X

更新日期：2013-07-01 00:00:00

abstract：:How lysosome and MTORC1 signaling interact remains elusive in terminally differentiated cells. A G4C2 repeat expansion in C9orf72 is the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9ALS-FTD). We previously identified a C9orf72-SMCR8-containing complex. Here we ...

journal_title：Autophagy

authors： Shao Q,Yang M,Liang C,Ma L,Zhang W,Jiang Z,Luo J,Lee JK,Liang C,Chen JF

更新日期：2020-09-01 00:00:00

abstract：:Autophagy acts as an intrinsic defense system against intracellular bacterial survival. Recently, multiple cellular pathways that target intracellular bacterial pathogens to autophagy have been described. These include the Atg5/LC3 pathway, which targets Shigella, the ubiquitin (Ub)-NDP52-LC3 pathway, which targets Gr...

journal_title：Autophagy

authors： Ogawa M,Yoshikawa Y,Mimuro H,Hain T,Chakraborty T,Sasakawa C

更新日期：2011-03-01 00:00:00

abstract：:Autophagy genes were first identified in the yeast system and some of their mammalian orthologues have also been characterized. Increasing lines of evidence indicate that various intracellular proteins, including G proteins, mammalian target of rapamycin (mTor) and Pl3K/Akt/PKB, of transmembrane signaling pathways are...

journal_title：Autophagy

authors： Jia G,Cheng G,Agrawal DK

更新日期：2007-01-01 00:00:00

abstract：:Autophagy is a complex, multi-step and biologically important pathway mediated by autophagosomes and autolysosomes. Accurately dissecting and detecting different stages of autophagy is important to elucidate its molecular mechanism and thereby facilitate the discovery of pharmaceutical molecules. We herein reported a ...

journal_title：Autophagy

authors： Chen JJ,Jing J,Chang H,Rong Y,Hai Y,Tang J,Zhang JL,Xu P

更新日期：2013-06-01 00:00:00

abstract：:The RNA replication complexes of small positive-strand RNA viruses such as poliovirus are known to form on the surfaces of membranous vesicles in the cytoplasm of infected mammalian cells. These membranes resemble cellular autophagosomes in their double-membraned morphology, cytoplasmic lumen, lipid-rich composition a...

journal_title：Autophagy

authors： Taylor MP,Kirkegaard K

更新日期：2008-04-01 00:00:00

abstract：:Ferroptosis is a form of regulated cell death caused by iron accumulation and oxidative injury. BECN1 is a key regulator of macroautophagy/autophagy, a catabolic process of degradation induced by starvation or other stressors. Our recent findings reveal a novel alternative mechanism by which BECN1 can promote ferropto...

journal_title：Autophagy

authors： Kang R,Zhu S,Zeh HJ,Klionsky DJ,Tang D

更新日期：2018-01-01 00:00:00

abstract：:Target of rapamycin complex 1 (TORC1) is an evolutionarily conserved protein kinase complex, whose activation in response to nutrients suppresses autophagy. In mammalian cells, amino-acid stimuli induce lysosomal translocation and activation of MTORC1 through the RRAG GTPase heterodimer, which is tethered to the surfa...

journal_title：Autophagy

authors： Fukuda T,Shiozaki K

更新日期：2018-01-01 00:00:00

abstract：:HSPB1 (heat shock protein family B [small] member 1) is a ubiquitously expressed molecular chaperone. Most mutations in HSPB1 cause axonal Charcot-Marie-Tooth neuropathy and/or distal hereditary motor neuropathy. In this study we show that mutations in HSPB1 lead to impairment of macroautophagic/autophagic flux. In HS...

journal_title：Autophagy

authors： Haidar M,Asselbergh B,Adriaenssens E,De Winter V,Timmermans JP,Auer-Grumbach M,Juneja M,Timmerman V

更新日期：2019-06-01 00:00:00

abstract：:Macroautophagy/autophagy is emerging as an important process in adult muscle stem cells functions: it regulates metabolic reprogramming during activation from a quiescent state, maintains stemness and prevents senescence. We now show that autophagy is specifically required for neonatal myogenesis and muscle developmen...

journal_title：Autophagy

authors： Zecchini S,Giovarelli M,Perrotta C,Morisi F,Touvier T,Di Renzo I,Moscheni C,Bassi MT,Cervia D,Sandri M,Clementi E,De Palma C

更新日期：2019-01-01 00:00:00

abstract：:Deficiency in decidualization has been widely regarded as an important cause of spontaneous abortion. Generalized decidualization also includes massive infiltration and enrichment of NK cells. However, the underlying mechanism of decidual NK (dNK) cell residence remains largely unknown. Here, we observe that the incre...

journal_title：Autophagy

authors： Lu H,Yang HL,Zhou WJ,Lai ZZ,Qiu XM,Fu Q,Zhao JY,Wang J,Li DJ,Li MQ

更新日期：2020-11-01 00:00:00

abstract：:DBI/ACBP (diazepam binding protein, acyl-CoA binding protein) participates in the regulation of fatty acid metabolism when it is localized within cells, whereas outside of cells it acts as a diazepam-binding protein. Recent results indicate that many different mammalian cell types release DBI/ACBP upon in vitro or in ...

journal_title：Autophagy

authors： Bravo-San Pedro JM,Sica V,Martins I,Anagnostopoulos G,Maiuri C,Kroemer G

更新日期：2019-11-01 00:00:00

abstract：:Autophagosomes arise in yeast and animals from the sealing of a cup-shaped double-membrane precursor, the phagophore. The concerted action of about 30 evolutionarily conserved autophagy related (ATG) proteins lies at the core of this process. However, the mechanisms allowing phagophore generation and its differentiati...

journal_title：Autophagy

authors： Le Bars R,Marion J,Satiat-Jeunemaitre B,Bianchi MW

更新日期：2014-10-01 00:00:00

abstract：:Pathological developments leading to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are associated with misbehavior of several key proteins, such as SOD1 (superoxide dismutase 1), TARDBP/TDP-43, FUS, C9orf72, and dipeptide repeat proteins generated as a result of the translation of th...

journal_title：Autophagy

authors： Uversky VN

更新日期：2017-01-01 00:00:00

abstract：:Science informs art, and art informs science. Both processes involve creativity and imagination, and collaboration between scientists and artists often leads to new insights in both fields. We took advantage of the power of artistic imagery to demonstrate a dynamic cellular process, autophagy. In particular, we depict...

journal_title：Autophagy

authors： Goodsell DS,Klionsky DJ

更新日期：2010-01-01 00:00:00

abstract：:Phosphatidylinositol-3-phosphate (PtdIns3P) is essential for generating autophagosomes and regulating endocytic trafficking. Recently, we have shown that the activities of human PIK3C3/VPS34-containing complexes I and II, which synthesize PtdIns3P, are greatly affected by three membrane physicochemical parameters: lip...

journal_title：Autophagy

authors： Ohashi Y,Tremel S,Williams RL

更新日期：2021-01-15 00:00:00

abstract：:Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies low back pain. Overloading-induced cell death, especially endogenous stem cell death, is the leading factor that undermines intrinsic repair and aggravates IDD. Previous research has separately studied the effect of oxygen conc...

journal_title：Autophagy

authors： He R,Wang Z,Cui M,Liu S,Wu W,Chen M,Wu Y,Qu Y,Lin H,Chen S,Wang B,Shao Z

更新日期：2021-01-18 00:00:00

abstract：:In 2013, Dr. Lora Hooper and colleagues described the induction of antibacterial macroautophagy/autophagy in intestinal epithelial cells as a cytoprotective host defense mechanism against invading Salmonella enterica serovar Typhimurium (S. Typhimurium). Canonical autophagy functions in a primarily degradative capacit...

journal_title：Autophagy

authors： Delorme-Axford E,Klionsky DJ

更新日期：2018-01-01 00:00:00

abstract：:Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms remain poorly understood. Here, we show that the RNA-binding protein ZFP36/TTP (ZFP36 ring finger protein) plays a crucial role in regulating ferroptosis in hepatic stellate cells (HSCs). Upon exposure to ferroptosis-indu...

journal_title：Autophagy

authors： Zhang Z,Guo M,Li Y,Shen M,Kong D,Shao J,Ding H,Tan S,Chen A,Zhang F,Zheng S

更新日期：2020-08-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a major modulator of cellular lipid metabolism and organelle differentiation. To understand whether autophagy is involved in the processes of dysregulated fatty acid oxidation and induced oxidative stress accompanying prostatic carcinogenesis, we characte...

journal_title：Autophagy

authors： Jiang M,Jerome WG,Hayward SW

更新日期：2010-01-01 00:00:00

abstract：:Autophagy research continues to expand exponentially. Clearly autophagy and metabolism are intimately connected; however, the rapid expansion of research into this topic inevitably brings the risk that important basic knowledge of metabolism will be overlooked when considering experimental data. Unfortunately, unaware...

journal_title：Autophagy

authors： Meijer AJ

更新日期：2009-01-01 00:00:00

abstract：:The life span of various model organisms can be extended by caloric restriction as well as by autophagy-inducing pharmacological agents. Life span-prolonging effects have also been observed in yeast cells, nematodes and flies upon the overexpression of the deacetylase Sirtuin-1. Intrigued by these observations and by ...

journal_title：Autophagy

authors： Morselli E,Maiuri MC,Markaki M,Megalou E,Pasparaki A,Palikaras K,Criollo A,Galluzzi L,Malik SA,Vitale I,Michaud M,Madeo F,Tavernarakis N,Kroemer G

更新日期：2010-01-01 00:00:00