Critical role of autophage in ischemia/reperfusion injury to aged livers.

abstract：:Under stress conditions cells activate different response pathways which result in cell survival or apoptosis depending on: (1) the nature of the insults, (2) the type, if acute or chronic stress, and (3) how long the stress persists. Generally, autophagy is induced early to sustain cell survival and inhibit cell deat...

journal_title：Autophagy

authors： Corazzari M,Fimia GM,Piacentini M

更新日期：2012-08-01 00:00:00

abstract：:The yeast serine threonine kinase Atg1 appears to be a key regulator of autophagy and its kinase activity is crucial for autophagy induction. Recent reports have indicated that a mammalian Atg1 homolog, UNC-51-like kinase (ULK) 1, is required for autophagy. We found that ULK1 localizes to the autophagic isolation memb...

journal_title：Autophagy

authors： Hara T,Mizushima N

更新日期：2009-01-01 00:00:00

abstract：:Vascular endothelial cells (VECs) that form the inner wall of blood vessels can be injured by high glucose-induced autophagy and apoptosis. Although the role of long noncoding RNA in regulating cell fate has received widespread attention, long noncoding RNAs (lncRNAs) that can both regulate autophagy and apoptosis nee...

journal_title：Autophagy

authors： Zhao X,Su L,He X,Zhao B,Miao J

更新日期：2020-01-01 00:00:00

abstract：:Understanding the role of autophagy in cancer has been limited by the inability to measure this dynamic process in formalin-fixed tissue. We considered that 3-dimensional models including ex vivo tumor, such as we have developed for studying mesothelioma, would provide valuable insights. Using these models, in which w...

journal_title：Autophagy

authors： Follo C,Barbone D,Richards WG,Bueno R,Broaddus VC

更新日期：2016-07-02 00:00:00

abstract：:Autophagy is a cellular degradation process with an increasingly recognised importance in many biological pathways such as nutrient sensing, stress responses and development. We present a straightforward assay for autophagy which combines the sensitivity of the EGFP-LC3 reporter protein with the throughput capacity an...

journal_title：Autophagy

authors： Eng KE,Panas MD,Karlsson Hedestam GB,McInerney GM

更新日期：2010-07-01 00:00:00

abstract：:Autophagy is a catabolic process employed by eukaryotes to degrade and recycle intracellular components. When this pathway is induced by starvation conditions, part of the cytoplasm and organelles are sequestered into double-membrane vesicles called autophagosomes, and delivered into the lysosome/vacuole for degradati...

journal_title：Autophagy

authors： Monastyrska I,Reggiori F,Klionsky DJ

更新日期：2008-10-01 00:00:00

abstract：:Macroautophagy/autophagy dysfunction is associated with many neurodegenerative diseases. TFEB (transcription factor EB), an important molecule that regulates lysosomal and autophagy function, is regarded as a potential target for treating some neurodegenerative diseases. However, the relationship between autophagy dys...

journal_title：Autophagy

authors： Ye B,Wang Q,Hu H,Shen Y,Fan C,Chen P,Ma Y,Wu H,Xiang M

更新日期：2019-06-01 00:00:00

abstract：:The role of autophagy in the degradation of aggregate-prone proteins has been well established. As a result, autophagy upregulation has become an attractive therapeutic strategy for the treatment of proteinopathies, a group of diseases caused by the accumulation of mutant misfolded proteins. We have previously shown t...

journal_title：Autophagy

authors： Menzies FM,Rubinsztein DC

更新日期：2010-02-01 00:00:00

abstract：:Macroautophagy/autophagy is a fundamental intracellular degradation process with multiple roles in immunity, including direct elimination of intracellular microorganisms via 'xenophagy.' In this review, we summarize studies from the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans that highlig...

journal_title：Autophagy

authors： Kuo CJ,Hansen M,Troemel E

更新日期：2018-01-01 00:00:00

abstract：:Neuroblastoma is the most common extracranial solid tumor in childhood. Despite intense multimodal therapy and many improvements through basic scientific and clinical research, the successful response of advanced-stage patients to chemotherapy remains poor. Autophagy is a cytoprotective mechanism that may help advance...

journal_title：Autophagy

authors： Oehme I,Lodrini M,Brady NR,Witt O

更新日期：2013-12-01 00:00:00

abstract：:Autophagy is one of the survival processes of cancer cells, especially in stressful conditions such as starvation, hypoxia and chemotherapeutic agents. However, its roles in tumor survival have not yet been fully elucidated. Here, we found for the first time that JAK2/STAT3 was activated in HeLa cells when they were s...

journal_title：Autophagy

authors： Yoon S,Woo SU,Kang JH,Kim K,Kwon MH,Park S,Shin HJ,Gwak HS,Chwae YJ

更新日期：2010-11-01 00:00:00

abstract：:Hyperactivation of mechanistic target of rapamycin (MTOR) is a common feature of human cancers, and MTOR inhibitors, such as rapamycin, are thus becoming therapeutics in targeting certain cancers. However, rapamycin has also been found to compromise the efficacy of chemotherapeutics to cells with hyperactive MTOR. Her...

journal_title：Autophagy

authors： Wang Y,Hu Z,Liu Z,Chen R,Peng H,Guo J,Chen X,Zhang H

更新日期：2013-12-01 00:00:00

abstract：:How lysosome and MTORC1 signaling interact remains elusive in terminally differentiated cells. A G4C2 repeat expansion in C9orf72 is the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9ALS-FTD). We previously identified a C9orf72-SMCR8-containing complex. Here we ...

journal_title：Autophagy

authors： Shao Q,Yang M,Liang C,Ma L,Zhang W,Jiang Z,Luo J,Lee JK,Liang C,Chen JF

更新日期：2020-09-01 00:00:00

abstract：:The ubiquitin-like conjugation reactions, ATG8/microtubule-associated protein 1 light chain 3/MAP1LC3 (LC3) to phosphatidylethanolamine (PE) and ATG12 to ATG5, are biochemical hallmarks for autophagy, a cellular process that degrades bulk cellular proteins and organelles. The two conjugation reactions share the same E...

journal_title：Autophagy

authors： Shao Y,Gao Z,Feldman T,Jiang X

更新日期：2007-01-01 00:00:00

abstract：:To maintain proper cellular homeostasis, the magnitude of autophagy activity has to be finely tuned in response to environmental changes. Many aspects of autophagy regulation have been extensively studied: pathways integrating signals through the master regulators TORC1 and PKA lead to multiple post-translational modi...

journal_title：Autophagy

authors： Bernard A,Klionsky DJ

更新日期：2015-04-03 00:00:00

abstract：:Drawing as a way of understanding things better/easier is in human nature, from textbook images through the models and graphical abstracts published in scientific papers to chalk talks during the academic job interview process. As a molecular cell biologist and geneticist, I always find it easier to show a microscopy ...

journal_title：Autophagy

authors： Juhász G

更新日期：2019-11-01 00:00:00

abstract：:The elimination of tumor cells by apoptosis is the main mechanism of action of chemotherapeutic drugs used in current treatment protocols of acute lymphoblastic leukemia (ALL). Despite the rapid cytoreduction achieved, serious acute and late complications are frequent, and resistance to chemotherapy develops. During t...

journal_title：Autophagy

authors： Crazzolara R,Bradstock KF,Bendall LJ

更新日期：2009-07-01 00:00:00

abstract：:One of the major side effects of cisplatin chemotherapy is toxic acute kidney injury due to preferential accumulation of cisplatin in renal proximal tubule epithelial cells and the subsequent injury to these cells. Apoptosis is known as a major mechanism of cisplatin-induced cell death in renal tubular cells. We have ...

journal_title：Autophagy

authors： Kaushal GP,Kaushal V,Herzog C,Yang C

更新日期：2008-07-01 00:00:00

abstract：:Macroautophagy/autophagy occurs at basal levels in all eukaryotic cells and plays an important role in maintaining bio-energetic homeostasis through the control of molecule degradation and organelle turnover. It can be induced by environmental conditions such as starvation, and is deregulated in many diseases includin...

journal_title：Autophagy

authors： Ceccariglia S,Cargnoni A,Silini AR,Parolini O

更新日期：2020-01-01 00:00:00

abstract：:Autophagy and apoptosis are 2 fundamental biological mechanisms that may cooperate or be antagonistic, although both are involved in deciding the fate of cells in physiological or pathological conditions. These 2 mechanisms coexist simultaneously in cells and share common upstream signals and stimuli. Autophagy and ap...

journal_title：Autophagy

authors： Ravegnini G,Sammarini G,Nannini M,Pantaleo MA,Biasco G,Hrelia P,Angelini S

更新日期：2017-03-04 00:00:00

abstract：:Mitochondrial morphological and structural changes play a role in several cellular processes, including apoptosis. We recently reported that mitochondrial elongation is also critical to sustain cell viability during macroautophagy. During macroautophagy unopposed mitochondrial fusion leads to organelle elongation both...

journal_title：Autophagy

authors： Gomes LC,Scorrano L

更新日期：2011-10-01 00:00:00

abstract：:Ridding neurons of toxic misfolded proteins is a critical feature of many neurodegenerative diseases. We have recently reported that lack of access of nuclear polyglutamine-expanded androgen receptor (AR) to the autophagic degradation pathway is a critical point in pathogenesis. When mutant AR is contained within the ...

journal_title：Autophagy

authors： Montie HL,Merry DE

更新日期：2009-11-01 00:00:00

abstract：:Autophagy describes the degradation of unnecessary or dysfunctional cellular components through the lysosomal machinery. Autophagy is essentially required to prevent accumulation of cellular damage and to ensure cellular homeostasis. Indeed, impaired autophagy has been implicated in a variety of different diseases. We...

journal_title：Autophagy

authors： Lin NY,Stefanica A,Distler JH

更新日期：2013-08-01 00:00:00

abstract：:(Macro)autophagy is a membrane-trafficking process that serves to sequester cellular constituents in organelles termed autophagosomes, which target their degradation in the lysosome. Autophagy operates at basal levels in all cells where it serves as a homeostatic mechanism to maintain cellular integrity. The levels an...

journal_title：Autophagy

authors： Wilkinson S,Croft DR,O'Prey J,Meedendorp A,O'Prey M,Dufès C,Ryan KM

更新日期：2011-11-01 00:00:00

abstract：:Autophagosome formation depends on a carefully orchestrated interplay between membrane-associated protein complexes. Initiation of macroautophagy/autophagy is mediated by the ULK1 (unc-51 like autophagy activating kinase 1) protein kinase complex and the autophagy-specific class III phosphatidylinositol 3-kinase compl...

journal_title：Autophagy

authors： Birgisdottir ÅB,Mouilleron S,Bhujabal Z,Wirth M,Sjøttem E,Evjen G,Zhang W,Lee R,O'Reilly N,Tooze SA,Lamark T,Johansen T

更新日期：2019-08-01 00:00:00

abstract：:Heme is an essential molecule expressed in many tissues where it plays key roles as the prosthetic group of several proteins involved in vital physiological and metabolic processes such as gas and electron transport. Structurally, heme is a tetrapyrrole ring containing an atom of iron (Fe) in its center. When released...

journal_title：Autophagy

authors： Travassos LH,Vasconcellos LR,Bozza MT,Carneiro LA

更新日期：2017-03-04 00:00:00

abstract：:There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria via a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We thus ...

journal_title：Autophagy

authors： Wu H,Wang Y,Li W,Chen H,Du L,Liu D,Wang X,Xu T,Liu L,Chen Q

更新日期：2019-11-01 00:00:00

abstract：:The European autophagy consortium Driving next-generation autophagy researchers towards translation (DRIVE) held its kick-off meeting in Groningen on the 14th and 15th of June 2018. This Marie Skłodowska-Curie Early Training Network was approved under the European Union's Horizon 2020 Research and Innovation Program a...

journal_title：Autophagy

authors： Kraft C,Boya P,Codogno P,Elazar Z,Eskelinen EL,Farrés J,Kirkin V,Jungbluth H,Martinez A,Pless O,Primard C,Proikas-Cezanne T,Simonsen A,Reggiori F

更新日期：2019-02-01 00:00:00

abstract：:Autophagy is a conserved membrane traffic pathway that equips eukaryotic cells to capture cytoplasmic components within a double-membrane vacuole, or autophagosome, for delivery to lysosomes. Although best known as a mechanism to survive starvation, autophagy is now recognized to combat infection by a variety of micro...

journal_title：Autophagy

authors： Dubuisson JF,Swanson MS

更新日期：2006-07-01 00:00:00

abstract：:Retinal ischemia is a major cause of vision loss and a common underlying mechanism associated with diseases, such as diabetic retinopathy and central retinal artery occlusion. We have previously demonstrated the robust neuroprotection in retina induced by post-conditioning (post-C), a brief period of ischemia, 24 h, f...

journal_title：Autophagy

authors： Mathew B,Chennakesavalu M,Sharma M,Torres LA,Stelman CR,Tran S,Patel R,Burg N,Salkovski M,Kadzielawa K,Seiler F,Aldrich LN,Roth S

更新日期：2020-05-26 00:00:00