Abstract:
:Autophagy describes the degradation of unnecessary or dysfunctional cellular components through the lysosomal machinery. Autophagy is essentially required to prevent accumulation of cellular damage and to ensure cellular homeostasis. Indeed, impaired autophagy has been implicated in a variety of different diseases. We examined the role of autophagy in inflammatory bone loss. We demonstrated that autophagy is activated by the pro-inflammatory cytokine tumor necrosis factor (TNF/TNFα) in osteoclasts of patients with rheumatoid arthritis (RA). Autophagy induces osteoclast differentiation and stimulates osteoclast-mediated bone resorption in vitro and in vivo, thereby highlighting autophagy as a novel mediator of TNF-induced bone resorption.
journal_name
Autophagyjournal_title
Autophagyauthors
Lin NY,Stefanica A,Distler JHdoi
10.4161/auto.25467subject
Has Abstractpub_date
2013-08-01 00:00:00pages
1253-5issue
8eissn
1554-8627issn
1554-8635pii
25467journal_volume
9pub_type
评论,杂志文章相关文献
Autophagy文献大全abstract::The molecular mechanism of macroautophagy/autophagy induction has been intensively studied, but little is known about downregulation of autophagy and how this process is restricted. In particular, how is autophagy maintained at an appropriate homeostatic level when cells are subjected to prolonged stress? In this stud...
journal_title:Autophagy
pub_type: 评论,社论
doi:10.1080/15548627.2016.1173802
更新日期:2016-07-02 00:00:00
abstract::Autophagy genes were first identified in the yeast system and some of their mammalian orthologues have also been characterized. Increasing lines of evidence indicate that various intracellular proteins, including G proteins, mammalian target of rapamycin (mTor) and Pl3K/Akt/PKB, of transmembrane signaling pathways are...
journal_title:Autophagy
pub_type: 评论,杂志文章,评审
doi:10.4161/auto.3427
更新日期:2007-01-01 00:00:00
abstract::To examine the functional significance and detailed morphological characteristics of starvation-induced autophagy in the adult heart, we starved green fluorescent protein (GFP)-microtubule-associated protein 1 light chain 3 (LC3) transgenic mice for up to 3 days. Electron microscopy revealed that, after as little as 1...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.7.9297
更新日期:2009-10-01 00:00:00
abstract::Macroautophagy is a complex process involving dynamic membrane rearrangements in which parts of the cytoplasm are sequestered within double-membrane phagophores. Upon completion, these structures mature into autophagosomes that fuse with the yeast vacuole or mammalian lysosome, leading to degradation of the cargo and ...
journal_title:Autophagy
pub_type: 社论
doi:10.4161/auto.27965
更新日期:2014-05-01 00:00:00
abstract::Macroautophagy/autophagy involves the formation of an autophagosome, a double-membrane vesicle that delivers sequestered cytoplasmic cargo to lysosomes for degradation and recycling. Closely related, endocytosis mediates the sorting and transport of cargo throughout the cell, and both processes are important for cellu...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1356976
更新日期:2017-10-03 00:00:00
abstract::In 2013, Dr. Lora Hooper and colleagues described the induction of antibacterial macroautophagy/autophagy in intestinal epithelial cells as a cytoprotective host defense mechanism against invading Salmonella enterica serovar Typhimurium (S. Typhimurium). Canonical autophagy functions in a primarily degradative capacit...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.1080/15548627.2017.1401425
更新日期:2018-01-01 00:00:00
abstract::Retinal ischemia is a major cause of vision loss and a common underlying mechanism associated with diseases, such as diabetic retinopathy and central retinal artery occlusion. We have previously demonstrated the robust neuroprotection in retina induced by post-conditioning (post-C), a brief period of ischemia, 24 h, f...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1767371
更新日期:2020-05-26 00:00:00
abstract::Ticks are long-lived hematophagous arthropods and have tolerance to starvation. They can survive without food during the host-seeking period for several months to years. To understand how ticks obtain energy over a long period of non-feeding (starvation), we focused on autophagy, a crucial proteolysis system via the l...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.4.11668
更新日期:2010-05-01 00:00:00
abstract::Autophagy is a major pathway for the degradation of long-lived proteins and cytoplasmic organelles and an essential part of programmed cell death, as well. Our findings indicate that programmed cell death of the ovarian follicle cells in the higher Diptera species Bactrocera oleae and Ceratitis capitata manifests feat...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.2858
更新日期:2006-10-01 00:00:00
abstract::Mitochondrial dysfunction is associated with the occurrence of a variety of neurodegenerative diseases, especially Alzheimer disease (AD). As a mitochondrial quality control process, mitophagy is greatly inhibited in AD; increasing evidence shows that the induction of mitophagy is an effective therapeutic intervention...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1860542
更新日期:2020-12-20 00:00:00
abstract::Post-translational modifications of autophagy-related (ATG) genes are necessary to modulate their functions. However, ATG protein methylation and its physiological role have not yet been elucidated. The methylation of non-histone proteins by SETD7, a SET domain-containing lysine methyltransferase, is a novel regulator...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1389357
更新日期:2018-01-01 00:00:00
abstract::Neuroepithelial cells undergoing differentiation efficiently remodel their cytoskeleton and shape in an energy-consuming process. The capacity of autophagy to recycle cellular components and provide energy could fulfill these requirements, thus supporting differentiation. However, little is known regarding the role of...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.8.2.18535
更新日期:2012-02-01 00:00:00
abstract::In a recent study, we reported in vivo evidence of early and sustained alterations of autophagy markers in a novel knock-in mouse model of Huntington disease (HD). The novel model is derived from selective breeding of HdhQ150 knock-in mice to generate mice with ~200 CAG/polyglutamine repeats (HdhQ200). HdhQ200 knockin...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.8.13617
更新日期:2010-11-01 00:00:00
abstract::The acetylase inhibitor, spermidine and the deacetylase activator, resveratrol, both induce autophagy and prolong life span of the model organism Caenorhabditis elegans in an autophagydependent fashion. Based on these premises, we investigated the differences and similarities in spermidine and resveratrol-induced auto...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.6.15191
更新日期:2011-06-01 00:00:00
abstract::Phagocytosis of naturally dying cells usually blocks inflammatory reactions in host cells. We have recently observed that clearance of cells dying through autophagy leads to a pro-inflammatory response in human macrophages. Investigating this response further, we found that during engulfment of MCF-7 or 293T cells und...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.3.14583
更新日期:2011-03-01 00:00:00
abstract::Autophagy is essential for prolonging yeast survival during nutrient deprivation; however, this report shows that some autophagy proteins may also be accelerating population death in those conditions. While leucine starvation caused YCA1-mediated apoptosis characterized by increased annexin V staining, nitrogen depriv...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19314
更新日期:2012-05-01 00:00:00
abstract::Macroautophagy/autophagy, an evolutionarily conserved eukaryotic bioprocess, plays an important role in the bulk degradation of intracellular macromolecules, organelles, and invading pathogens. PIK3C3/VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3) functions as a key protein in autophagy initiation and ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1743071
更新日期:2020-06-01 00:00:00
abstract::A hallmark of macroautophagy is the formation of autophagosomes, double-membrane vesicles that enwrap cellular components destined for lysosomal degradation. We examined autophagosomal protein dynamics under various inducing stimuli using a comprehensive mass spectrometry-based proteomics approach in combination with ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.20286
更新日期:2012-06-01 00:00:00
abstract::Aged and damaged mitochondria can be selectively degraded by specific autophagic elimination, termed mitophagy. Defects in mitophagy have been increasingly linked to several diseases including neurodegenerative diseases, metabolic diseases and other aging-related diseases. However, the molecular mechanisms of mitophag...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2018.1501251
更新日期:2018-01-01 00:00:00
abstract::Abnormal aggregation of SNCA/?-synuclein plays a crucial role in Parkinson disease (PD) pathogenesis. SNCA levels determine its toxicity, and its accumulation, even to a small extent, may be a risk factor for neurodegeneration. One of the main pathways for SNCA degradation is chaperone-mediated autophagy (CMA), a sele...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.26451
更新日期:2013-12-01 00:00:00
abstract::Coxsackievirus B3 (CVB3) has previously been shown to utilize autophagy in an advantageous manner during the course of infection of the host cell. However, few studies have determined whether stem cells induce autophagy in a similar fashion, and whether virus-induced autophagy occurs following infection of stem cells....
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19781
更新日期:2012-06-01 00:00:00
abstract::How lysosome and MTORC1 signaling interact remains elusive in terminally differentiated cells. A G4C2 repeat expansion in C9orf72 is the most common cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (C9ALS-FTD). We previously identified a C9orf72-SMCR8-containing complex. Here we ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1703353
更新日期:2020-09-01 00:00:00
abstract::Regulated degradation of cellular components by lysosomes is essential to maintain biological homeostasis. In mammals, three forms of autophagy, macroautophagy, microautophagy and chaperone-mediated autophagy (CMA), have been identified. Here, we showed a novel type of autophagy, in which RNA is taken up directly into...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.23002
更新日期:2013-03-01 00:00:00
abstract::A steady increase in life expectancy has resulted in an equivalent increase in elderly patients who are more susceptible to diseases than young patients. In a recent study, we found that in both in vitro and in vivo models of ischemia/reperfusion (I/R), a loss of ATG4B is causatively associated with the increased sens...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.8.1.18391
更新日期:2012-01-01 00:00:00
abstract::The European autophagy consortium Driving next-generation autophagy researchers towards translation (DRIVE) held its kick-off meeting in Groningen on the 14th and 15th of June 2018. This Marie Skłodowska-Curie Early Training Network was approved under the European Union's Horizon 2020 Research and Innovation Program a...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2018.1515532
更新日期:2019-02-01 00:00:00
abstract::The proteasome inhibitor bortezomib has shown remarkable clinical success in the treatment of multiple myeloma. However, the efficacy and mechanism of action of bortezomib in solid tumor malignancies is less well understood. In addition, the use of this first-in-class proteasome inhibitor is limited by several factors...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.22185
更新日期:2012-12-01 00:00:00
abstract::Recent evidence has indicated that the lysosome is able to act as a signaling organelle that senses nutrient availability and generates an adaptive response that is important for cellular homeostasis. We recently discovered another example of lysosomal signaling where lysosomal calcium release activates the master aut...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.1080/15548627.2015.1047130
更新日期:2015-01-01 00:00:00
abstract::Autophagosomes arise in yeast and animals from the sealing of a cup-shaped double-membrane precursor, the phagophore. The concerted action of about 30 evolutionarily conserved autophagy related (ATG) proteins lies at the core of this process. However, the mechanisms allowing phagophore generation and its differentiati...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.29962
更新日期:2014-10-01 00:00:00
abstract::Quercetin, a dietary antioxidant present in fruits and vegetables, is a promising cancer chemopreventive agent that inhibits tumor promotion by inducing cell cycle arrest and promoting apoptotic cell death. In this study, we examined the biological activities of quercetin against gastric cancer. Our studies demonstrat...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.9.15863
更新日期:2011-09-01 00:00:00
abstract::Macroautophagy (referred to as autophagy) is an evolutionarily conserved, bulk-destruction process in eukaryotes. During this process, the cytoplasm containing long-lived proteins and organelles is engulfed into double-membrane autophagosomes, and ultimately undergoes enzymatic degradation within lysosomes. Autophagy ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.8.13508
更新日期:2010-11-01 00:00:00