Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells.

abstract：:Macroautophagy/autophagy is the main intracellular catabolic pathway in neurons that eliminates misfolded proteins, aggregates and damaged organelles associated with ageing and neurodegeneration. Autophagy is regulated by both MTOR-dependent and -independent pathways. There is increasing evidence that autophagy is com...

journal_title：Autophagy

authors： Perera ND,Sheean RK,Lau CL,Shin YS,Beart PM,Horne MK,Turner BJ

更新日期：2018-01-01 00:00:00

abstract：:Atg13 is an essential subunit of the Atg1 autophagy initiation complex in yeast and its mammalian counterpart, ATG13, is indispensable for autophagy induction by the ULK1 complex. The N terminus of the protein folds into a HORMA domain, an architecture that has been revealed by crystallography. 1-4 In human cells, the...

journal_title：Autophagy

authors： Popelka H,Klionsky DJ

更新日期：2017-03-04 00:00:00

abstract：:Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fa...

journal_title：Autophagy

authors： Dorn GW 2nd

更新日期：2016-01-01 00:00:00

abstract：:The best-characterized process of autophagy is macroautophagy. Many an article or talk has started with the phrase "...macroautophagy, hereafter referred to as autophagy." This one will be different because we are going to learn more about the person most responsible for increasing our understanding of chaperone-media...

journal_title：Autophagy

authors： Dice JF

更新日期：2009-11-01 00:00:00

abstract：:Nanotechnology is the control and manipulation of materials in the size range of 1-100 nm. Due to increasing research into the potential beneficial applications of nanotechnology, there is an urgent need for the study of possible health risks. Several researchers, including those in our laboratory, have demonstrated e...

journal_title：Autophagy

authors： Stern ST,Johnson DN

更新日期：2008-11-01 00:00:00

abstract：:Our laboratory has been investigating for some time the nature of the response of T lymphocytes in autoimmunity in the reactions against self-proteins that result in a number of diseases, such as type 1 diabetes, multiple sclerosis, rheumatoid arthritis (RA) and others. T cells recognize peptides generated from protei...

journal_title：Autophagy

authors： Ireland JM,Unanue ER

更新日期：2012-03-01 00:00:00

abstract：:The class III phosphatidylinositol (PtdIns)-3 kinase, PIK3C3/VPS34, forms multiple complexes and regulates a variety of cellular functions, especially in intracellular vesicle trafficking and autophagy. Even though PtdIns3P, the product of PIK3C3, is thought to be a critical membrane marker for the autophagosome, it i...

journal_title：Autophagy

authors： Kim J,Guan KL

更新日期：2013-07-01 00:00:00

abstract：:Autophagy or Type II programmed cell death (PCD) is a major intracellular pathway for the degradation and recycling of proteins, ribosomes and entire organelles. The role of this pathway in the antitumor effect of radiotherapy and in radiation toxicity is obscure. A complicated machinery of genes and proteins is invol...

journal_title：Autophagy

authors： Zois CE,Koukourakis MI

更新日期：2009-05-01 00:00:00

abstract：:One of the major side effects of cisplatin chemotherapy is toxic acute kidney injury due to preferential accumulation of cisplatin in renal proximal tubule epithelial cells and the subsequent injury to these cells. Apoptosis is known as a major mechanism of cisplatin-induced cell death in renal tubular cells. We have ...

journal_title：Autophagy

authors： Kaushal GP,Kaushal V,Herzog C,Yang C

更新日期：2008-07-01 00:00:00

abstract：:Premenopausal women have better survival than men after intracerebral hemorrhage, which is associated with iron overproduction and autophagy induction. To examine the participation of neuronal autophagy and estrogen receptor α (ERα) in the E 2-mediated protection, PC12 neurons treated with Atg7 (autophagy-related prot...

journal_title：Autophagy

authors： Chen CW,Chen TY,Tsai KL,Lin CL,Yokoyama KK,Lee WS,Chiueh CC,Hsu C

更新日期：2012-10-01 00:00:00

abstract：:The role of autophagy in the degradation of aggregate-prone proteins has been well established. As a result, autophagy upregulation has become an attractive therapeutic strategy for the treatment of proteinopathies, a group of diseases caused by the accumulation of mutant misfolded proteins. We have previously shown t...

journal_title：Autophagy

authors： Menzies FM,Rubinsztein DC

更新日期：2010-02-01 00:00:00

abstract：:Here, we present a summary of our recent findings on the (patho-)physiological relevance of PINK1-phosphorylated ubiquitin (p-S65-Ub). Using novel polyclonal antibodies, we find that p-S65-Ub specifically accumulates on damaged mitochondria. Phosphorylation of ubiquitin on serine 65 depends on the activity of PINK1 an...

journal_title：Autophagy

authors： Fiesel FC,Springer W

更新日期：2015-11-02 00:00:00

abstract：:(Macro)autophagy is a membrane-trafficking process that serves to sequester cellular constituents in organelles termed autophagosomes, which target their degradation in the lysosome. Autophagy operates at basal levels in all cells where it serves as a homeostatic mechanism to maintain cellular integrity. The levels an...

journal_title：Autophagy

authors： Wilkinson S,Croft DR,O'Prey J,Meedendorp A,O'Prey M,Dufès C,Ryan KM

更新日期：2011-11-01 00:00:00

abstract：:A shared neuropathological hallmark in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is nuclear clearance and cytoplasmic aggregation of TARDBP/TDP-43 (TAR DNA binding protein). We previously showed that the ability of TARDBP to repress nonconserved cryptic exons was impaired in brains of patie...

journal_title：Autophagy

authors： Donde A,Sun M,Jeong YH,Wen X,Ling J,Lin S,Braunstein K,Nie S,Wang S,Chen L,Wong PC

更新日期：2020-04-01 00:00:00

abstract：:The critical role of the cellular autophagy pathway in viral infection and pathogenesis has become increasingly apparent. Mounting evidences suggest that viruses have developed different strategies to meticulously modulate intracellular autophagy for their own benefits, thereby either promoting efficient viral replica...

journal_title：Autophagy

authors： Liang C,E X,Jung JU

更新日期：2008-04-01 00:00:00

abstract：:Infection and inflammation are able to induce diet-independent Na+-accumulation without commensurate water retention in afflicted tissues, which favors the pro-inflammatory activation of mouse macrophages and augments their antibacterial and antiparasitic activity. While Na+-boosted host defense against the protozoan ...

journal_title：Autophagy

authors： Neubert P,Weichselbaum A,Reitinger C,Schatz V,Schröder A,Ferdinand JR,Simon M,Bär AL,Brochhausen C,Gerlach RG,Tomiuk S,Hammer K,Wagner S,van Zandbergen G,Binger KJ,Müller DN,Kitada K,Clatworthy MR,Kurts C,Titze J,

更新日期：2019-11-01 00:00:00

abstract：:Abnormal aggregation of SNCA/?-synuclein plays a crucial role in Parkinson disease (PD) pathogenesis. SNCA levels determine its toxicity, and its accumulation, even to a small extent, may be a risk factor for neurodegeneration. One of the main pathways for SNCA degradation is chaperone-mediated autophagy (CMA), a sele...

journal_title：Autophagy

authors： Xilouri M,Brekk OR,Kirik D,Stefanis L

更新日期：2013-12-01 00:00:00

abstract：:Autophagy is a degradative process conserved among eukaryotic cells. It allows the elimination of cytoplasm including aberrant protein aggregates and damaged organelles. Accordingly, it is implicated in normal developmental processes and also serves a protective role in tumor suppression and elimination of invading pa...

journal_title：Autophagy

authors： Reggiori F,Shintani T,Nair U,Klionsky DJ

更新日期：2005-07-01 00:00:00

abstract：:Autophagy is a catabolic process employed by eukaryotes to degrade and recycle intracellular components. When this pathway is induced by starvation conditions, part of the cytoplasm and organelles are sequestered into double-membrane vesicles called autophagosomes, and delivered into the lysosome/vacuole for degradati...

journal_title：Autophagy

authors： Monastyrska I,Reggiori F,Klionsky DJ

更新日期：2008-10-01 00:00:00

abstract：:Retinal ischemia is a major cause of vision loss and a common underlying mechanism associated with diseases, such as diabetic retinopathy and central retinal artery occlusion. We have previously demonstrated the robust neuroprotection in retina induced by post-conditioning (post-C), a brief period of ischemia, 24 h, f...

journal_title：Autophagy

authors： Mathew B,Chennakesavalu M,Sharma M,Torres LA,Stelman CR,Tran S,Patel R,Burg N,Salkovski M,Kadzielawa K,Seiler F,Aldrich LN,Roth S

更新日期：2020-05-26 00:00:00

abstract：:It has been a longstanding problem to identify specific and efficient pharmacological modulators of autophagy. Recently, we found that depletion of acetyl-coenzyme A (AcCoA) induced autophagic flux, while manipulations designed to increase cytosolic AcCoA efficiently inhibited autophagy. Thus, the cell permeant ester ...

journal_title：Autophagy

authors： Mariño G,Pietrocola F,Kong Y,Eisenberg T,Hill JA,Madeo F,Kroemer G

更新日期：2014-05-01 00:00:00

abstract：:Mitochondrial morphological and structural changes play a role in several cellular processes, including apoptosis. We recently reported that mitochondrial elongation is also critical to sustain cell viability during macroautophagy. During macroautophagy unopposed mitochondrial fusion leads to organelle elongation both...

journal_title：Autophagy

authors： Gomes LC,Scorrano L

更新日期：2011-10-01 00:00:00

abstract：:It has not been elucidated whether or not autophagy is induced by rhabdoviral G glycoproteins (G) in vertebrate organisms for which rhabdovirus infection is lethal. Our work provides the first evidence that both mammalian (vesicular stomatitis virus, VSV) and fish (viral hemorrhagic septicemia virus, VHSV, and spring ...

journal_title：Autophagy

authors： García-Valtanen P,Ortega-Villaizán Mdel M,Martínez-López A,Medina-Gali R,Pérez L,Mackenzie S,Figueras A,Coll JM,Estepa A

更新日期：2014-09-01 00:00:00

abstract：:Inhibition of the autophagic pathway has recently revealed promising results in increasing pro-death activity of multiple cancer therapeutics. Here, we discuss our findings regarding the autophagy-blocking and anti-neoplastic effects of a synthetic sphingosine analog, FTY720, in mantle cell lymphoma (MCL). We also emp...

journal_title：Autophagy

authors： Alinari L,Baiocchi RA,Praetorius-Ibba M

更新日期：2012-03-01 00:00:00

abstract：:The understanding of the membrane flow process during autophagosome formation is essential to illuminate the role of autophagy under various disease-causing conditions. Atg9 is the only identified integral membrane protein required for autophagosome formation, and it is thought to cycle between the membrane sources an...

journal_title：Autophagy

authors： He C,Baba M,Klionsky DJ

更新日期：2009-04-01 00:00:00

abstract：:To study mitochondrial protein age dynamics, we targeted a time-sensitive fluorescent protein, MitoTimer, to the mitochondrial matrix. Mitochondrial age was revealed by the integrated portions of young (green) and old (red) MitoTimer protein. Mitochondrial protein age was dependent on turnover rates as pulsed synthesi...

journal_title：Autophagy

authors： Ferree AW,Trudeau K,Zik E,Benador IY,Twig G,Gottlieb RA,Shirihai OS

更新日期：2013-11-01 00:00:00

abstract：:SPHK1 (sphingosine kinase 1), a regulator of sphingolipid metabolites, plays a causal role in the development of hepatocellular carcinoma (HCC) through augmenting HCC invasion and metastasis. However, the mechanism by which SPHK1 signaling promotes invasion and metastasis in HCC remains to be clarified. Here, we repor...

journal_title：Autophagy

authors： Liu H,Ma Y,He HW,Zhao WL,Shao RG

更新日期：2017-05-04 00:00:00

abstract：:The AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis by sensing the metabolic status of the cell. AMPK is regulated by phosphorylation and dephosphorylation as a result of changing AMP/ATP levels and by removal of inhibitory ubiquitin residues by USP10. In this context, we identified the GID-c...

journal_title：Autophagy

authors： Liu H,Ding J,Köhnlein K,Urban N,Ori A,Villavicencio-Lorini P,Walentek P,Klotz LO,Hollemann T,Pfirrmann T

更新日期：2020-09-01 00:00:00

abstract：:Age-related macular degeneration (AMD) is a complex, degenerative and progressive eye disease that usually does not lead to complete blindness, but can result in severe loss of central vision. Risk factors for AMD include age, genetics, diet, smoking, oxidative stress and many cardiovascular-associated risk factors. A...

journal_title：Autophagy

authors： Kaarniranta K,Sinha D,Blasiak J,Kauppinen A,Veréb Z,Salminen A,Boulton ME,Petrovski G

更新日期：2013-07-01 00:00:00

abstract：:Blood-brain barrier (BBB) disruption is a key event in triggering secondary damage to the central nervous system (CNS) under stroke, and is frequently associated with abnormal macroautophagy/autophagy in brain microvascular endothelial cells (BMECs). However, the underlying mechanism of autophagy in maintaining BBB in...

journal_title：Autophagy

authors： Yang Z,Lin P,Chen B,Zhang X,Xiao W,Wu S,Huang C,Feng D,Zhang W,Zhang J

更新日期：2020-12-07 00:00:00