Abstract:
:Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fatty-acid metabolizing mitochondria. Our findings demonstrate how functional interactions between mitophagic mitochondrial removal and biogenic mitochondrial replacement facilitate metabolic maturation of the heart.
journal_name
Autophagyjournal_title
Autophagyauthors
Dorn GW 2nddoi
10.1080/15548627.2016.1143210subject
Has Abstractpub_date
2016-01-01 00:00:00pages
610-1issue
3eissn
1554-8627issn
1554-8635journal_volume
12pub_type
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