Unconventional autophagy mediated by the WD40 domain of ATG16L1 is derailed by the T300A Crohn disease risk polymorphism.

abstract：:Although several oncogenes enhance autophagic flux, the molecular mechanism and consequences of oncogene-induced autophagy remain to be clarified. We have recently shown that expression of oncogenic H-Ras (V12) promotes autophagy through upregulation of Beclin 1 and the BH3-only protein Noxa. H-Ras-expressing cells un...

journal_title：Autophagy

authors： Martin SJ

更新日期：2011-08-01 00:00:00

abstract：:Induced pluripotent stem cells (iPSCs) have fewer and immature mitochondria than somatic cells and mainly rely on glycolysis for energy source. During somatic cell reprogramming, somatic mitochondria and other organelles get remodeled. However, events of organelle remodeling and interaction during somatic cell reprogr...

journal_title：Autophagy

authors： Xiang G,Yang L,Long Q,Chen K,Tang H,Wu Y,Liu Z,Zhou Y,Qi J,Zheng L,Liu W,Ying Z,Fan W,Shi H,Li H,Lin X,Gao M,Liu J,Bao F,Li L,Duan L,Li M,Liu X

更新日期：2017-09-02 00:00:00

abstract：:The lysosome is a key subcellular organelle that receives and degrades macromolecules from endocytic, secretory and autophagic pathways. Lysosomal function is thus critical for an efficient autophagic process. However, the molecular mechanisms mediating lysosomal function upon autophagic induction are largely unknown....

journal_title：Autophagy

authors： Zhou J,Tan SH,Codogno P,Shen HM

更新日期：2013-05-01 00:00:00

abstract：:The endothelium plays a central role in the regulation of vascular wall cellularity and tone by secreting an array of mediators of importance in intercellular communication. Nutrient deprivation of human endothelial cells (EC) evokes unconventional forms of secretion leading to the release of nanovesicles distinct fro...

journal_title：Autophagy

authors： Sirois I,Groleau J,Pallet N,Brassard N,Hamelin K,Londono I,Pshezhetsky AV,Bendayan M,Hébert MJ

更新日期：2012-06-01 00:00:00

abstract：:Autophagy is a catabolic process employed by eukaryotes to degrade and recycle intracellular components. When this pathway is induced by starvation conditions, part of the cytoplasm and organelles are sequestered into double-membrane vesicles called autophagosomes, and delivered into the lysosome/vacuole for degradati...

journal_title：Autophagy

authors： Monastyrska I,Reggiori F,Klionsky DJ

更新日期：2008-10-01 00:00:00

abstract：:Vascular endothelial cells (VECs) that form the inner wall of blood vessels can be injured by high glucose-induced autophagy and apoptosis. Although the role of long noncoding RNA in regulating cell fate has received widespread attention, long noncoding RNAs (lncRNAs) that can both regulate autophagy and apoptosis nee...

journal_title：Autophagy

authors： Zhao X,Su L,He X,Zhao B,Miao J

更新日期：2020-01-01 00:00:00

abstract：:Coxsackievirus B3 (CVB3) has previously been shown to utilize autophagy in an advantageous manner during the course of infection of the host cell. However, few studies have determined whether stem cells induce autophagy in a similar fashion, and whether virus-induced autophagy occurs following infection of stem cells....

journal_title：Autophagy

authors： Tabor-Godwin JM,Tsueng G,Sayen MR,Gottlieb RA,Feuer R

更新日期：2012-06-01 00:00:00

abstract：:Based on my reading, and on my own experience, I have come to realize that people learn in different ways, and this can include the use of different media. This is one reason I have worked with various artists to portray the topic of autophagy through paintings, music and dance. Indeed, comments from members of the au...

journal_title：Autophagy

authors： Klionsky DJ

更新日期：2019-09-01 00:00:00

abstract：:Autophagy has been recently proposed to be a component of the innate cellular immune response against several types of intracellular microorganisms. However, other intracellular bacteria including Listeria monocytogenes have been thought to evade the autophagic cellular surveillance. Here, we show that cellular infect...

journal_title：Autophagy

authors： Py BF,Lipinski MM,Yuan J

更新日期：2007-03-01 00:00:00

abstract：:Bulk degradation and nutrient recycling are events associated with autophagy. The core components of the autophagy machinery have been elucidated recently using molecular and genetic approaches. In particular, two ubiquitin-like proteins, ATG8 and ATG12, which conjugate with phosphatidylethanolamine (PE) and ATG5, res...

journal_title：Autophagy

authors： Xiao S,Chye ML

更新日期：2010-08-01 00:00:00

abstract：:Autophagy is a conserved homeostatic process in which cytoplasmic contents are degraded and recycled. Two ubiquitin-like conjugation pathways are required for the generation of autophagosomes, and ATG5 is necessary for both of these processes. Studies of mice deficient in ATG5 reveal a key role for autophagy in T lymp...

journal_title：Autophagy

authors： Conway KL,Kuballa P,Khor B,Zhang M,Shi HN,Virgin HW,Xavier RJ

更新日期：2013-04-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) often metastasizes to the brain, but identifying which patients will develop brain metastases (BM) is difficult. Macroautophagy/autophagy is critical for cancer initiation and progression. We hypothesized that genetic variants of autophagy-related genes may affect brain metastases (B...

journal_title：Autophagy

authors： Li QX,Zhou X,Huang TT,Tang Y,Liu B,Peng P,Sun L,Wang YH,Yuan XL

更新日期：2017-06-03 00:00:00

abstract：:Microglia are innate immune cells in the central nervous system (CNS), that supplies neurons with key factors for executing autophagosomal/lysosomal functions. Macroautophagy/autophagy is a cellular catabolic process that maintains cell balance in response to stress-related stimulation. Abnormal autophagy occurs with ...

journal_title：Autophagy

authors： Li Y,Zhou D,Ren Y,Zhang Z,Guo X,Ma M,Xue Z,Lv J,Liu H,Xi Q,Jia L,Zhang L,Liu Y,Zhang Q,Yan J,Da Y,Gao F,Yue J,Yao Z,Zhang R

更新日期：2019-03-01 00:00:00

abstract：:A shared neuropathological hallmark in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is nuclear clearance and cytoplasmic aggregation of TARDBP/TDP-43 (TAR DNA binding protein). We previously showed that the ability of TARDBP to repress nonconserved cryptic exons was impaired in brains of patie...

journal_title：Autophagy

authors： Donde A,Sun M,Jeong YH,Wen X,Ling J,Lin S,Braunstein K,Nie S,Wang S,Chen L,Wong PC

更新日期：2020-04-01 00:00:00

abstract：:Autophagy is a process by which cytoplasmic material is sequestered in a double-membrane vesicle destined for degradation. Nutrient deprivation stimulates the pathway and the number of autophagosomes in the cell increases in response to such stimulus. In the current report we have demonstrated that actin is necessary ...

journal_title：Autophagy

authors： Aguilera MO,Berón W,Colombo MI

更新日期：2012-11-01 00:00:00

abstract：:Neuroepithelial cells undergoing differentiation efficiently remodel their cytoskeleton and shape in an energy-consuming process. The capacity of autophagy to recycle cellular components and provide energy could fulfill these requirements, thus supporting differentiation. However, little is known regarding the role of...

journal_title：Autophagy

authors： Vázquez P,Arroba AI,Cecconi F,de la Rosa EJ,Boya P,de Pablo F

更新日期：2012-02-01 00:00:00

abstract：:Premenopausal women have better survival than men after intracerebral hemorrhage, which is associated with iron overproduction and autophagy induction. To examine the participation of neuronal autophagy and estrogen receptor α (ERα) in the E 2-mediated protection, PC12 neurons treated with Atg7 (autophagy-related prot...

journal_title：Autophagy

authors： Chen CW,Chen TY,Tsai KL,Lin CL,Yokoyama KK,Lee WS,Chiueh CC,Hsu C

更新日期：2012-10-01 00:00:00

abstract：:We analyzed the cellular and molecular effects of two different histone deacetylase inhibitors (HDACi), MGCD0103 and vorinostat, in combination with GX15-070, a BH3-mimetic, in acute myeloid leukemia (AML) cell lines and primary AML cells, and demonstrated that the combination has a synergistic antileukemia effect. We...

journal_title：Autophagy

authors： Wei Y,Kadia T,Tong W,Zhang M,Jia Y,Yang H,Hu Y,Viallet J,O'Brien S,Garcia-Manero G

更新日期：2010-10-01 00:00:00

abstract：:Oxidative stress-induced granulosa cell (GCs) death represents a common reason for follicular atresia. Follicle-stimulating hormone (FSH) has been shown to prevent GCs from oxidative injury, although the underlying mechanism remains to be elucidated. Here we first report that the suppression of autophagic cell death v...

journal_title：Autophagy

authors： Shen M,Jiang Y,Guan Z,Cao Y,Li L,Liu H,Sun SC

更新日期：2017-08-03 00:00:00

abstract：:A major side effect of the powerful immunosuppressive drug cyclosporine (CsA) is the development of a chronic nephrotoxicity whose mechanisms are not fully understood. Recent data suggest that tubular cells play a central role in the pathogenesis of chronic nephropathies. We have shown that CsA is responsible for endo...

journal_title：Autophagy

authors： Pallet N,Bouvier N,Legendre C,Gilleron J,Codogno P,Beaune P,Thervet E,Anglicheau D

更新日期：2008-08-01 00:00:00

abstract：:Macroautophagy/autophagy is a conserved catabolic process that maintains cellular homeostasis under basal growth and stress conditions. In cancer, autophagy can either prevent or promote tumor growth, at early or advanced stages, respectively. We screened public databases to identify autophagy-related somatic mutation...

journal_title：Autophagy

authors： Nuta GC,Gilad Y,Gershoni M,Sznajderman A,Schlesinger T,Bialik S,Eisenstein M,Pietrokovski S,Kimchi A

更新日期：2019-03-01 00:00:00

abstract：:Macroautophagy sequesters superflous cytosol and organelles into double-membraned autophagosomes. Over 30 autophagy-related (ATG) genes have been identified without elucidating the molecular details of autophagosome biogenesis. All proposed models for autophagosome formation require membrane fusion events (Fig. 1). Pr...

journal_title：Autophagy

authors： Krick R,Bremer S,Welter E,Eskelinen EL,Thumm M

更新日期：2011-02-01 00:00:00

abstract：:Autophagy is involved in cellular clearance of aggregate-prone proteins, thereby having a cytoprotective function. Studies in yeast have shown that the PI 3-kinase Vps34 and its regulatory protein kinase Vps15 are important for autophagy, but the possible involvement of these proteins in autophagy in a multicellular a...

journal_title：Autophagy

authors： Lindmo K,Brech A,Finley KD,Gaumer S,Contamine D,Rusten TE,Stenmark H

更新日期：2008-05-01 00:00:00

abstract：:The initiation of macroautophagy/autophagy is tightly regulated by the upstream ULK1 kinase complex, which affects many downstream factors including the PtdIns3K complex. The phosphorylation of the right position at the right time on downstream molecules is governed by proper complex formation. One component of the UL...

journal_title：Autophagy

authors： Kim BW,Jin Y,Kim J,Kim JH,Jung J,Kang S,Kim IY,Kim J,Cheong H,Song HK

更新日期：2018-01-01 00:00:00

abstract：:Autophagy and apoptosis are 2 fundamental biological mechanisms that may cooperate or be antagonistic, although both are involved in deciding the fate of cells in physiological or pathological conditions. These 2 mechanisms coexist simultaneously in cells and share common upstream signals and stimuli. Autophagy and ap...

journal_title：Autophagy

authors： Ravegnini G,Sammarini G,Nannini M,Pantaleo MA,Biasco G,Hrelia P,Angelini S

更新日期：2017-03-04 00:00:00

abstract：:Mitochondrial dysfunction is associated with the occurrence of a variety of neurodegenerative diseases, especially Alzheimer disease (AD). As a mitochondrial quality control process, mitophagy is greatly inhibited in AD; increasing evidence shows that the induction of mitophagy is an effective therapeutic intervention...

journal_title：Autophagy

authors： Cen X,Xu X,Xia H

更新日期：2020-12-20 00:00:00

abstract：:Antagonizing the strongly activated pathway of autophagy in renal ischemic injury has been associated with poor outcome. In our recent study we used mice with a selective deletion of Atg5 in the S3 proximal tubule segment, which is most susceptible to ischemic damage. In line with the notion that autophagy is a prosur...

journal_title：Autophagy

authors： Melk A,Baisantry A,Schmitt R

更新日期：2016-01-01 00:00:00

abstract：:Macroautophagy/autophagy mediates the degradation of ubiquitinated aggregated proteins within lysosomes in a process known as aggrephagy. The cargo receptor SQSTM1/p62 condenses aggregated proteins into larger structures and links them to the nascent autophagosomal membrane (phagophore). How the condensation reaction ...

journal_title：Autophagy

authors： Turco E,Witt M,Abert C,Bock-Bierbaum T,Su MY,Trapannone R,Sztacho M,Danieli A,Shi X,Zaffagnini G,Gamper A,Schuschnig M,Fracchiolla D,Bernklau D,Romanov J,Hartl M,Hurley JH,Daumke O,Martens S

更新日期：2019-08-01 00:00:00

abstract：:We have previously shown that Kaposi sarcoma-associated herpesvirus (KSHV) impairs monocyte differentiation into dendritic cells (DCs). Macroautophagy/autophagy has been reported to be essential in such a differentiating process. Here we extended these studies and found that the impairment of DC formation by KSHV occu...

journal_title：Autophagy

authors： Santarelli R,Granato M,Pentassuglia G,Lacconi V,Gilardini Montani MS,Gonnella R,Tafani M,Torrisi MR,Faggioni A,Cirone M

更新日期：2016-12-01 00:00:00

abstract：:It has not been elucidated whether or not autophagy is induced by rhabdoviral G glycoproteins (G) in vertebrate organisms for which rhabdovirus infection is lethal. Our work provides the first evidence that both mammalian (vesicular stomatitis virus, VSV) and fish (viral hemorrhagic septicemia virus, VHSV, and spring ...

journal_title：Autophagy

authors： García-Valtanen P,Ortega-Villaizán Mdel M,Martínez-López A,Medina-Gali R,Pérez L,Mackenzie S,Figueras A,Coll JM,Estepa A

更新日期：2014-09-01 00:00:00