KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression.

abstract：:Mutations in the ER-associated VAPB/ALS8 protein cause amyotrophic lateral sclerosis and spinal muscular atrophy. Previous studies have argued that ER stress may underlie the demise of neurons. We find that loss of VAP proteins (VAPs) leads to an accumulation of aberrant lysosomes and impairs lysosomal degradation. VA...

journal_title：Autophagy

authors： Mao D,Lin G,Tepe B,Zuo Z,Tan KL,Senturk M,Zhang S,Arenkiel BR,Sardiello M,Bellen HJ

更新日期：2019-07-01 00:00:00

abstract：:The accumulation of ubiquitin-positive protein aggregates has been implicated in the pathogenesis of neurodegenerative diseases, heart disease and diabetes. Emerging evidence indicates that the autophagy lysosomal pathway plays a critical role in the clearance of ubiquitin aggregates, a process that is mediated by the...

journal_title：Autophagy

authors： Fan W,Tang Z,Chen D,Moughon D,Ding X,Chen S,Zhu M,Zhong Q

更新日期：2010-07-01 00:00:00

abstract：:Autophagy is a lysosome-mediated catabolic process involving the degradation of intracellular contents (e.g., proteins and organelles) as well as invading microbes (e.g., parasites, bacteria and viruses). Multiple forms of cellular stress can stimulate this pathway, including nutritional imbalances, oxygen deprivation...

journal_title：Autophagy

authors： Zhang Q,Kang R,Zeh HJ 3rd,Lotze MT,Tang D

更新日期：2013-04-01 00:00:00

abstract：:Microtubule-associated protein light chain 3 (LC3) is now widely used to monitor autophagy. One approach is to detect LC3 conversion (LC3-I to LC3-II) by immunoblot analysis because the amount of LC3-II is clearly correlated with the number of autophagosomes. However, LC3-II itself is degraded by autophagy, making int...

journal_title：Autophagy

authors： Mizushima N,Yoshimori T

更新日期：2007-11-01 00:00:00

abstract：:The Pacific oyster, Crassostrea gigas, is a mollusk bivalve commercially important as a food source. Pacific oysters are subjected to stress and diseases during culture. The autophagy pathway is involved in numerous cellular processes, including responses to starvation, cell death, and microorganism elimination. Autop...

journal_title：Autophagy

authors： Picot S,Faury N,Arzul I,Chollet B,Renault T,Morga B

更新日期：2020-11-01 00:00:00

abstract：:In the world of pathogen-host cell interactions, the autophagic pathway has been recently described as a component of the innate immune response against intracellular microorganisms. Indeed, some bacterial survival mechanisms are hampered when this process is activated. Mycobacterium tuberculosis infection of macropha...

journal_title：Autophagy

authors： Colombo MI,Gutierrez MG,Romano PS

更新日期：2006-07-01 00:00:00

abstract：:Photodynamic therapy (PDT) is a procedure that has applications in the selective eradication of neoplasia where sites of malignant lesions are clearly delineated. It is a two-step process whereby cells are first sensitized to light and then photoirradiated. This results in the formation of singlet molecular oxygen and...

journal_title：Autophagy

authors： Reiners JJ Jr,Agostinis P,Berg K,Oleinick NL,Kessel D

更新日期：2010-01-01 00:00:00

abstract：:Tumor hypoxia underlies treatment failure and yields more aggressive and metastatic cancer phenotypes. Although therapeutically targeting these hypoxic environments has been proposed for many years, to date no approaches have shown the therapeutic value to gain regulatory approval. Here, we demonstrated that a novel h...

journal_title：Autophagy

authors： Liu XW,Cai TY,Zhu H,Cao J,Su Y,Hu YZ,He QJ,Yang B

更新日期：2014-01-01 00:00:00

abstract：:The extensive autophagic-lysosomal pathology in Alzheimer disease (AD) brain has revealed a major defect: in the proteolytic clearance of autophagy substrates. Autophagy failure contributes on several levels to AD pathogenesis and has become an important therapeutic target for AD and other neurodegenerative diseases. ...

journal_title：Autophagy

authors： Yang DS,Stavrides P,Mohan PS,Kaushik S,Kumar A,Ohno M,Schmidt SD,Wesson DW,Bandyopadhyay U,Jiang Y,Pawlik M,Peterhoff CM,Yang AJ,Wilson DA,St George-Hyslop P,Westaway D,Mathews PM,Levy E,Cuervo AM,Nixon RA

更新日期：2011-07-01 00:00:00

abstract：:Our laboratory has been investigating for some time the nature of the response of T lymphocytes in autoimmunity in the reactions against self-proteins that result in a number of diseases, such as type 1 diabetes, multiple sclerosis, rheumatoid arthritis (RA) and others. T cells recognize peptides generated from protei...

journal_title：Autophagy

authors： Ireland JM,Unanue ER

更新日期：2012-03-01 00:00:00

abstract：:Mitochondrial dysfunction is an early sign of many neurodegenerative diseases. Very recently, two Parkinson disease (PD) associated genes, PINK1 and Parkin, were shown to mediate the degradation of damaged mitochondria via selective autophagy (mitophagy). PINK1 kinase activity is needed for prompt and efficient Parkin...

journal_title：Autophagy

authors： Geisler S,Holmström KM,Treis A,Skujat D,Weber SS,Fiesel FC,Kahle PJ,Springer W

更新日期：2010-10-01 00:00:00

abstract：:A major side effect of the powerful immunosuppressive drug cyclosporine (CsA) is the development of a chronic nephrotoxicity whose mechanisms are not fully understood. Recent data suggest that tubular cells play a central role in the pathogenesis of chronic nephropathies. We have shown that CsA is responsible for endo...

journal_title：Autophagy

authors： Pallet N,Bouvier N,Legendre C,Gilleron J,Codogno P,Beaune P,Thervet E,Anglicheau D

更新日期：2008-08-01 00:00:00

abstract：:Accumulation of mutant TP53 proteins in cancer cells has been recognized as an important factor that promotes cancer progression and metastasis. Thus, strategies that promote the degradation of mutant TP53 might be beneficial for the treatment of cancers. In a recent issue of Genes & Development, we demonstrated that ...

journal_title：Autophagy

authors： Vakifahmetoglu-Norberg H,Yuan J

更新日期：2013-12-01 00:00:00

abstract：:microRNAs (miRNAs) are a class of small regulatory RNAs that regulate gene expression at the post-transcriptional level. miRNAs play important roles in the regulation of development, growth, and metastasis of cancer, and in determining the response of tumor cells to anticancer therapy. In recent years, they have also ...

journal_title：Autophagy

authors： Yu Y,Cao L,Yang L,Kang R,Lotze M,Tang D

更新日期：2012-05-01 00:00:00

abstract：:This study summarizes our most recent findings on the mechanisms underlying the cadmium-induced death of mesangial cells, which leads to nephrotoxicity. Multiple pathways participate in cadmium-induced nephrotoxicity. In the ROS-GSK-3beta autophagy pathway, cadmium induces ROS most likely from the mitochondria, and th...

journal_title：Autophagy

authors： Yang LY,Wu KH,Chiu WT,Wang SH,Shih CM

更新日期：2009-05-01 00:00:00

abstract：:Macroautophagy is induced under various stresses to remove cytotoxic materials, including misfolded proteins and their aggregates. These protein cargoes are collected by specific autophagic receptors such as SQSTM1/p62 (sequestosome 1) and delivered to phagophores for lysosomal degradation. To date, little is known ab...

journal_title：Autophagy

authors： Lee DH,Kim D,Kim ST,Jeong S,Kim JL,Shim SM,Heo AJ,Song X,Guo ZS,Bartlett DL,Oh SC,Lee J,Saito Y,Kim BY,Kwon YT,Lee YJ

更新日期：2018-01-01 00:00:00

abstract：:Autophagy describes the degradation of unnecessary or dysfunctional cellular components through the lysosomal machinery. Autophagy is essentially required to prevent accumulation of cellular damage and to ensure cellular homeostasis. Indeed, impaired autophagy has been implicated in a variety of different diseases. We...

journal_title：Autophagy

authors： Lin NY,Stefanica A,Distler JH

更新日期：2013-08-01 00:00:00

abstract：:Multiple stress pathways result in the induction of autophagy and apoptosis. Current methods (e.g., protein gel blot, microscopy) do not offer quantitative single-cell resolution, thus making it difficult to discern if these pathways are mutually exclusive or, in some situations, cooperative in executing cell death. W...

journal_title：Autophagy

authors： de la Calle C,Joubert PE,Law HK,Hasan M,Albert ML

更新日期：2011-09-01 00:00:00

abstract：:Sexual reproduction is the most common form of reproduction among eukaryotes, which is characterized by a series of massive cellular or tissue renovations. Recent studies have revealed novel functions of autophagy during sexual reproductive processes, ranging from yeast to mammals. In mammals, autophagy is indispensab...

journal_title：Autophagy

authors： Gao H,Khawar MB,Li W

更新日期：2020-01-01 00:00:00

abstract：:Infection and inflammation are able to induce diet-independent Na+-accumulation without commensurate water retention in afflicted tissues, which favors the pro-inflammatory activation of mouse macrophages and augments their antibacterial and antiparasitic activity. While Na+-boosted host defense against the protozoan ...

journal_title：Autophagy

authors： Neubert P,Weichselbaum A,Reitinger C,Schatz V,Schröder A,Ferdinand JR,Simon M,Bär AL,Brochhausen C,Gerlach RG,Tomiuk S,Hammer K,Wagner S,van Zandbergen G,Binger KJ,Müller DN,Kitada K,Clatworthy MR,Kurts C,Titze J,

更新日期：2019-11-01 00:00:00

abstract：:In a series of studies into the fate of endothelial cells exposed to non-enzymatically glycated collagen I, a model of cytotoxic molecules relevant to diabetic vasculopathy, we demonstrate that cells either undergo apoptosis or become prematurely senescent despite relatively spared telomeres and telomerase activity. O...

journal_title：Autophagy

authors： Patschan S,Goligorsky MS

更新日期：2008-05-01 00:00:00

abstract：:A steady increase in life expectancy has resulted in an equivalent increase in elderly patients who are more susceptible to diseases than young patients. In a recent study, we found that in both in vitro and in vivo models of ischemia/reperfusion (I/R), a loss of ATG4B is causatively associated with the increased sens...

journal_title：Autophagy

authors： Wang JH,Behrns KE,Leeuwenburgh C,Kim JS

更新日期：2012-01-01 00:00:00

abstract：:Target of rapamycin complex 1 (TORC1) is an evolutionarily conserved protein kinase complex, whose activation in response to nutrients suppresses autophagy. In mammalian cells, amino-acid stimuli induce lysosomal translocation and activation of MTORC1 through the RRAG GTPase heterodimer, which is tethered to the surfa...

journal_title：Autophagy

authors： Fukuda T,Shiozaki K

更新日期：2018-01-01 00:00:00

abstract：:The lack of a rapid and quantitative autophagy assay has substantially hindered the development and implementation of autophagy-targeting therapies for a variety of human diseases. To address this critical issue, we developed a novel autophagy assay using the newly developed Cyto-ID fluorescence dye. We first verified...

journal_title：Autophagy

authors： Guo S,Liang Y,Murphy SF,Huang A,Shen H,Kelly DF,Sobrado P,Sheng Z

更新日期：2015-01-01 00:00:00

abstract：:Survival of environmental stress conditions requires the maintenance of cellular homeostasis. To preserve this balance, cells utilize a degradative mechanism known as autophagy. During this process, in response to starvation or other stresses, bulk cytoplasm is non-specifically sequestered within double-membrane vesic...

journal_title：Autophagy

authors： Legakis JE,Yen WL,Klionsky DJ

更新日期：2007-09-01 00:00:00

abstract：:Phagocytosis of naturally dying cells usually blocks inflammatory reactions in host cells. We have recently observed that clearance of cells dying through autophagy leads to a pro-inflammatory response in human macrophages. Investigating this response further, we found that during engulfment of MCF-7 or 293T cells und...

journal_title：Autophagy

authors： Petrovski G,Ayna G,Majai G,Hodrea J,Benko S,Mádi A,Fésüs L

更新日期：2011-03-01 00:00:00

abstract：:The multifaceted process of aging inevitably leads to disturbances in cellular metabolism and protein homeostasis. To meet this challenge, cells make use of autophagy, which is probably one of the most important pathways preserving cellular protection under stressful conditions. Thus, efficient autophagic flux is requ...

journal_title：Autophagy

authors： Eisenberg T,Schroeder S,Büttner S,Carmona-Gutierrez D,Pendl T,Andryushkova A,Mariño G,Pietrocola F,Harger A,Zimmermann A,Magnes C,Sinner F,Sedej S,Pieber TR,Dengjel J,Sigrist S,Kroemer G,Madeo F

更新日期：2014-06-01 00:00:00

abstract：:Autophagy is a process by which cytoplasmic material is sequestered in a double-membrane vesicle destined for degradation. Nutrient deprivation stimulates the pathway and the number of autophagosomes in the cell increases in response to such stimulus. In the current report we have demonstrated that actin is necessary ...

journal_title：Autophagy

authors： Aguilera MO,Berón W,Colombo MI

更新日期：2012-11-01 00:00:00

abstract：:To examine the functional significance and detailed morphological characteristics of starvation-induced autophagy in the adult heart, we starved green fluorescent protein (GFP)-microtubule-associated protein 1 light chain 3 (LC3) transgenic mice for up to 3 days. Electron microscopy revealed that, after as little as 1...

journal_title：Autophagy

authors： Takemura G,Kanamori H,Goto K,Maruyama R,Tsujimoto A,Fujiwara H,Seishima M,Minatoguchi S

更新日期：2009-10-01 00:00:00

abstract：:In almost all animals, mitochondrial DNA (mtDNA) is transmitted only from the female, while the paternal mitochondria and mtDNA are thought to be eliminated during early embryogenesis. Autophagy is involved in the elimination of sperm mitochondria and mtDNA in early embryos in Caenorhabditis elegans; however, solid ev...

journal_title：Autophagy

authors： Luo SM,Sun QY

更新日期：2013-12-01 00:00:00