Abstract:
:Sexual reproduction is the most common form of reproduction among eukaryotes, which is characterized by a series of massive cellular or tissue renovations. Recent studies have revealed novel functions of autophagy during sexual reproductive processes, ranging from yeast to mammals. In mammals, autophagy is indispensable for spermatogenesis and oogenesis, and it participates in early embryonic development and maternal-fetus crosstalk to ensure the development of embryos or fetuses. Thus, autophagy provides the molecular basis for resource allocation among parents and their offspring, providing an important way to benefit the next generation.Abbreviations: ATG: autophagy-related; Becn1: beclin 1, autophagy related; CMA: chaperone-mediated autophagy; epg: ectopic PGL granules; ES: ectoplasmic specialization; EVTs: extravillous trophoblasts; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; PCD: programmed cell death; PTB: preterm birth; STB: syncytiotrophoblast.
journal_name
Autophagyjournal_title
Autophagyauthors
Gao H,Khawar MB,Li Wdoi
10.1080/15548627.2019.1628543subject
Has Abstractpub_date
2020-01-01 00:00:00pages
18-27issue
1eissn
1554-8627issn
1554-8635journal_volume
16pub_type
杂志文章,评审相关文献
Autophagy文献大全abstract::UVRAG is a promoter of the autophagy pathway, and its deficiency may fuel the development of cancers. Intriguingly, our recent study has demonstrated that this protein also mediates the repair of damaged DNA and patrols centrosome stability, mechanisms that commonly prevent cancer progression, in a manner independent ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.21035
更新日期:2012-09-01 00:00:00
abstract::Ubiquitin-proteasome system and autophagy are the two major mechanisms for protein degradation in eukaryotic cells. LC3, a ubiquitin-like protein, plays an essential role in autophagy through its ability to be conjugated to phosphatidylethanolamine. In this study, we discovered a novel LC3-processing activity, and bio...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.1.10928
更新日期:2010-01-01 00:00:00
abstract::Minocycline has been shown to alleviate several neurological disorders. Unexpectedly, we found that minocycline had opposite effects on glioma cells: minocycline induced nonapoptotic cell death in glioma cells. The glioma cell death was associated with the presence of autophagic vacuoles in the cytoplasm. Minocycline ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.2.14043
更新日期:2011-02-01 00:00:00
abstract::Macroautophagy/autophagy, a fundamental process for degradation of macromolecules and organelles, occurs constitutively at a basal level and is upregulated in response to stress. Whether autophagy regulates protein acetylation and microtubule stability in vascular smooth muscle cells (VSMCs) migration, however, remain...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1707488
更新日期:2020-10-01 00:00:00
abstract::Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fa...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1143210
更新日期:2016-01-01 00:00:00
abstract::Although the treatments of malignant glioma include surgery, radiotherapy and chemotherapy by oral drug administration, the prognosis of patients with glioma remains very poor. We developed a polyethylene glycol-dipalmitoylphosphatidyle- thanoiamine (mPEG-DPPE) calcium phosphate nanoparticles (NPs) injectable thermore...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1320634
更新日期:2017-07-03 00:00:00
abstract::FTY720, a sphingosine analog, is a novel immunosuppressant currently undergoing multiple clinical trials for the prevention of organ transplant rejection and treatment of various autoimmune diseases. Recent studies indicate an additional cytotoxic effect of FTY720 and its preclinical efficacy in a variety of cancer mo...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.8.13614
更新日期:2010-11-01 00:00:00
abstract::Macroautophagy/autophagy occurs at basal levels in all eukaryotic cells and plays an important role in maintaining bio-energetic homeostasis through the control of molecule degradation and organelle turnover. It can be induced by environmental conditions such as starvation, and is deregulated in many diseases includin...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.1080/15548627.2019.1630223
更新日期:2020-01-01 00:00:00
abstract::Selective autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. This process is a specific degradation pathway for a wide variety of substrates including unwanted cytosolic components, such as protein aggregates, damaged and/or superfluous organelles, and pathogens. Howeve...
journal_title:Autophagy
pub_type: 社论
doi:10.1080/15548627.2020.1798199
更新日期:2020-10-01 00:00:00
abstract::Autophagy is a fundamental process for anti-viral defense. Not surprisingly, viruses have developed strategies to subvert or use autophagy for their own benefit. In cell culture, autophagy proteins are proviral factors that favor initiation of hepatitis C virus (HCV) infection. Autophagy proteins are required for tran...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.8.10219
更新日期:2009-11-01 00:00:00
abstract::Autophagy acts as an intrinsic defense system against intracellular bacterial survival. Recently, multiple cellular pathways that target intracellular bacterial pathogens to autophagy have been described. These include the Atg5/LC3 pathway, which targets Shigella, the ubiquitin (Ub)-NDP52-LC3 pathway, which targets Gr...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.7.3.14581
更新日期:2011-03-01 00:00:00
abstract::The etiological agent for anthrax is Bacillus anthracis, which produces lethal toxin (LT) that exerts a myriad of effects on many immune cells. In our previous study, it was demonstrated that LT and protective antigen (PA) induce autophagy in mammalian cells. Preliminary results suggest that autophagy may function as ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.5.8567
更新日期:2009-07-01 00:00:00
abstract::Adaptive immunity, which plays an important role in the development of atherosclerosis, is mediated by major histocompatibility complex (MHC)-dependent antigen presentation. In atherosclerotic lesions, macrophages constitute an important class of antigen-presenting cells that activate adaptive immune responses to oxid...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2015.1037061
更新日期:2015-01-01 00:00:00
abstract::Flies expressing the most common Parkinson disease (PD)-related mutation, LRRK2-G2019S, in their dopaminergic neurons show loss of visual function and degeneration of the retina, including mitochondrial abnormalities, apoptosis and autophagy. Since the photoreceptors that degenerate are not dopaminergic, this demonstr...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.24397
更新日期:2013-06-01 00:00:00
abstract::We have recently shown the roles of an autophagy gene in the regulation of metabolism and metabolic diseases. We identified Becn2/Beclin 2, a novel mammalian specific homolog of Becn1/Beclin 1, characterized the functions of the gene product in autophagy and agonist-induced lysosome-mediated downregulation of a subset...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.29414
更新日期:2014-08-01 00:00:00
abstract::The ability to respond and adapt to changes in the physical environment is a universal and essential cellular property. Here we demonstrated that cells respond to mechanical compressive stress by rapidly inducing autophagosome formation. We measured this response in both Dictyostelium and mammalian cells, indicating t...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.12.17924
更新日期:2011-12-01 00:00:00
abstract::The NIH-funded center for autophagy research named Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence, located at the University of New Mexico Health Science Center is now completing its second year as a working center with a mission to promote autophagy research locally, nationally...
journal_title:Autophagy
pub_type: 历史文章,杂志文章
doi:10.1080/15548627.2019.1634444
更新日期:2019-10-01 00:00:00
abstract::Formation of the autophagosome is likely the most complex step of macroautophagy, and indeed it is the morphological and functional hallmark of this process; accordingly, it is critical to understand the corresponding molecular mechanism. Atg8 is the only known autophagy-related (Atg) protein required for autophagosom...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19385
更新日期:2012-05-01 00:00:00
abstract::In the world of pathogen-host cell interactions, the autophagic pathway has been recently described as a component of the innate immune response against intracellular microorganisms. Indeed, some bacterial survival mechanisms are hampered when this process is activated. Mycobacterium tuberculosis infection of macropha...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.2827
更新日期:2006-07-01 00:00:00
abstract::Burkholderia pseudomallei is the causative agent of melioidosis, a tropical infection of humans and other animals. The bacterium is an intracellular pathogen that can escape from endosomes into the host cytoplasm, where it replicates and infects adjacent cells. We investigated the role played by autophagy in the intra...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6246
更新日期:2008-08-01 00:00:00
abstract::ULK1 (unc51-like autophagy activating kinase 1) is a serine/threonine kinase that plays a key role in regulating macroautophagy/autophagy induction in response to amino acid starvation. Despite the recent progress in understanding ULK1 functions, the molecular mechanism by which ULK1 regulates the induction of autopha...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1422851
更新日期:2018-01-01 00:00:00
abstract::Protein synthesis and autophagy work as two opposing processes to control cell growth in response to nutrient supply. The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) pathway, which acts as a master regulator to control protein synthesis, has recently been shown to inhibit autophagy by phosphorylating ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.7.15491
更新日期:2011-07-01 00:00:00
abstract::Chronic lung inflammation is accepted as being associated with the development of lung cancer caused by nickel exposure. Therefore, identifying the molecular mechanisms that lead to a nickel-induced sustained inflammatory microenvironment that causes transformation of human bronchial epithelial cells is of high signif...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1196313
更新日期:2016-10-02 00:00:00
abstract::Alterations in contractile activity influence the intracellular homeostasis of muscle, which results in adaptations in the performance and the phenotype of this tissue. Denervation is an effective disuse model that functions to change the intracellular environment of muscle leading to a rapid loss in mass, a decrease ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.2.7391
更新日期:2009-02-01 00:00:00
abstract::A shared neuropathological hallmark in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is nuclear clearance and cytoplasmic aggregation of TARDBP/TDP-43 (TAR DNA binding protein). We previously showed that the ability of TARDBP to repress nonconserved cryptic exons was impaired in brains of patie...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1635379
更新日期:2020-04-01 00:00:00
abstract::In the fungal pathogen Fusarium oxysporum, vegetative hyphal fusion triggers nuclear mitotic division in the invading hypha followed by migration of a nucleus into the receptor hypha and degradation of the resident nucleus. Here we examined the role of autophagy in fusion-induced nuclear degradation. A search of the F...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/15548627.2014.994413
更新日期:2015-01-01 00:00:00
abstract::Infection and inflammation are able to induce diet-independent Na+-accumulation without commensurate water retention in afflicted tissues, which favors the pro-inflammatory activation of mouse macrophages and augments their antibacterial and antiparasitic activity. While Na+-boosted host defense against the protozoan ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1596483
更新日期:2019-11-01 00:00:00
abstract::The understanding of the membrane flow process during autophagosome formation is essential to illuminate the role of autophagy under various disease-causing conditions. Atg9 is the only identified integral membrane protein required for autophagosome formation, and it is thought to cycle between the membrane sources an...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.3.7699
更新日期:2009-04-01 00:00:00
abstract::Tumor hypoxia underlies treatment failure and yields more aggressive and metastatic cancer phenotypes. Although therapeutically targeting these hypoxic environments has been proposed for many years, to date no approaches have shown the therapeutic value to gain regulatory approval. Here, we demonstrated that a novel h...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.26838
更新日期:2014-01-01 00:00:00
abstract::Heme is an essential molecule expressed in many tissues where it plays key roles as the prosthetic group of several proteins involved in vital physiological and metabolic processes such as gas and electron transport. Structurally, heme is a tetrapyrrole ring containing an atom of iron (Fe) in its center. When released...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1271515
更新日期:2017-03-04 00:00:00