Abstract:
:We have recently shown the roles of an autophagy gene in the regulation of metabolism and metabolic diseases. We identified Becn2/Beclin 2, a novel mammalian specific homolog of Becn1/Beclin 1, characterized the functions of the gene product in autophagy and agonist-induced lysosome-mediated downregulation of a subset of G protein-coupled receptors (GPCRs), and proposed a model of dual functions of BECN2 in these 2 lysosomal degradation pathways. Further analyses revealed that knockout of Becn2 dramatically decreases embryonic survival in homozygotes, and leads to metabolic dysregulation in heterozygotes, which is likely caused by disruption of GPCR signaling. This finding suggests that besides autophagy, BECN/Beclin family members may play a role in the regulation of a broader spectrum of intracellular signaling pathways.
journal_name
Autophagyjournal_title
Autophagyauthors
Zhang W,He Cdoi
10.4161/auto.29414subject
Has Abstractpub_date
2014-08-01 00:00:00pages
1472-3issue
8eissn
1554-8627issn
1554-8635pii
29414journal_volume
10pub_type
杂志文章相关文献
Autophagy文献大全abstract::A wide variety of genetic, pharmacological and nutrient manipulations that extend lifespan in model organisms do so in a manner dependent upon increased autophagic flux. However, our recent findings suggest that when mitochondrial membrane integrity is compromised, macroautophagy/autophagy can be detrimental. In C. el...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1644077
更新日期:2019-10-01 00:00:00
abstract::In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea cycle and CPS1 are only present in the liver and, to a minor extent, in the kidney. To address the possibility that SIRT5 is involved i...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2015.1009778
更新日期:2015-01-01 00:00:00
abstract::Phagocytosis and macroautophagy/autophagy are 2 processes involved in lysosome-mediated clearance of extracellular and intracellular components, respectively. Recent studies have identified the recruitment of the autophagic protein LC3 during phagocytosis of apoptotic corpses in what is now called LC3-associated phago...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2018.1512452
更新日期:2019-02-01 00:00:00
abstract::Delivery of cellular contents to yeast vacuoles/mammalian lysosomes via autophagy ensures long-term cell survival and extends life span. When cultured yeast cells are grown for a prolonged period of time to enter stationary phase, a nondividing state mimicking quiescence, vacuolar membrane proteins partition into eith...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.36137
更新日期:2014-01-01 00:00:00
abstract::Thioglycolate-elicited macrophages exhibit abundant conjugation of LC3 with PE (LC3-II). Among other autophagy-related (ATG) proteins, it is proposed that, like in yeast, both ATG5 and ATG7 are essential for LC3 conjugation. Using atg5-deficient ( -/- ) and atg7-/- macroph...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2021.1874132
更新日期:2021-01-18 00:00:00
abstract::Phagocytosis of naturally dying cells usually blocks inflammatory reactions in host cells. We have recently observed that clearance of cells dying through autophagy leads to a pro-inflammatory response in human macrophages. Investigating this response further, we found that during engulfment of MCF-7 or 293T cells und...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.3.14583
更新日期:2011-03-01 00:00:00
abstract::Pathological developments leading to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are associated with misbehavior of several key proteins, such as SOD1 (superoxide dismutase 1), TARDBP/TDP-43, FUS, C9orf72, and dipeptide repeat proteins generated as a result of the translation of th...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.1080/15548627.2017.1384889
更新日期:2017-01-01 00:00:00
abstract::Age-related macular degeneration (AMD) is a complex, degenerative and progressive eye disease that usually does not lead to complete blindness, but can result in severe loss of central vision. Risk factors for AMD include age, genetics, diet, smoking, oxidative stress and many cardiovascular-associated risk factors. A...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.24546
更新日期:2013-07-01 00:00:00
abstract::The Atg1/ULK1 complex plays a central role in starvation-induced autophagy, integrating signals from upstream sensors such as MTOR and AMPK and transducing them to the downstream autophagy pathway. Much progress has been made in the last few years in understanding the mechanisms by which the complex is regulated throu...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.23323
更新日期:2013-02-01 00:00:00
abstract::Premenopausal women have better survival than men after intracerebral hemorrhage, which is associated with iron overproduction and autophagy induction. To examine the participation of neuronal autophagy and estrogen receptor α (ERα) in the E 2-mediated protection, PC12 neurons treated with Atg7 (autophagy-related prot...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.21289
更新日期:2012-10-01 00:00:00
abstract::Autophagy is a lysosome-directed membrane trafficking event for the degradation of cytoplasmic components, including organelles. The past few years have seen a great advance in our understanding of the cellular machinery of autophagosome biogenesis, the hallmark of autophagy. However, our global understanding of autop...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6496
更新日期:2008-08-01 00:00:00
abstract::The Pacific oyster, Crassostrea gigas, is a mollusk bivalve commercially important as a food source. Pacific oysters are subjected to stress and diseases during culture. The autophagy pathway is involved in numerous cellular processes, including responses to starvation, cell death, and microorganism elimination. Autop...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1713643
更新日期:2020-11-01 00:00:00
abstract::Understanding of the mechanism for myeloid differentiation provides important insights into the hematopoietic developmental processes. By using an ESC-derived myeloid progenitor cell model, we found that CSF2/GM-CSF triggered macrophage differentiation and activation of the MTOR signaling pathway. Activation or inhibi...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1578040
更新日期:2019-07-01 00:00:00
abstract::Macroautophagy/autophagy, an evolutionarily conserved eukaryotic bioprocess, plays an important role in the bulk degradation of intracellular macromolecules, organelles, and invading pathogens. PIK3C3/VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3) functions as a key protein in autophagy initiation and ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1743071
更新日期:2020-06-01 00:00:00
abstract::Cytotoxic necrotizing factor 1 is a bacterial protein toxin from Escherichia coli that is able to activate the Rho GTPases and to hinder apoptosis and mitotic catastrophe. Upon exposure to toxin, cells undergo a complex framework of changes, including cytoskeleton remodeling and multinucleation. These cells also show ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.2965
更新日期:2006-10-01 00:00:00
abstract::Inhibition of the autophagic pathway has recently revealed promising results in increasing pro-death activity of multiple cancer therapeutics. Here, we discuss our findings regarding the autophagy-blocking and anti-neoplastic effects of a synthetic sphingosine analog, FTY720, in mantle cell lymphoma (MCL). We also emp...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19050
更新日期:2012-03-01 00:00:00
abstract::Autophagy genes were first identified in the yeast system and some of their mammalian orthologues have also been characterized. Increasing lines of evidence indicate that various intracellular proteins, including G proteins, mammalian target of rapamycin (mTor) and Pl3K/Akt/PKB, of transmembrane signaling pathways are...
journal_title:Autophagy
pub_type: 评论,杂志文章,评审
doi:10.4161/auto.3427
更新日期:2007-01-01 00:00:00
abstract::Autophagy is a highly conserved degradation pathway for intracellular macromolecules and organelles. Among those characterized autophagy regulators, the ubiquitin-like protein Atg8 is found to be a membrane modifier that both regulates biogenesis of transport vesicles and interacts with the cargo receptor Atg19 for se...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.4.7696
更新日期:2009-05-01 00:00:00
abstract::Autophagy plays critical roles in plant responses to stress. In contrast to the wealth of information concerning the core process of plant autophagosome assembly, our understanding of the regulation of autophagy is limited. In this study, we demonstrated that transcription factor HsfA1a played a critical role in tomat...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2015.1098798
更新日期:2015-11-02 00:00:00
abstract::Actin plays indispensable roles in autophagosome biogenesis. Branched actin networks assembled within phagophore membranes are required for generating the autophagosome membrane shape and movement. The ARP2/3 complex and its regulators, such as JMY (junction mediating and regulatory protein, p53 cofactor), translocate...
journal_title:Autophagy
pub_type: 评论,社论
doi:10.1080/15548627.2018.1564417
更新日期:2019-03-01 00:00:00
abstract::Nutrients not only act as building blocks but also as signaling molecules. Nutrient-availability promotes cell growth and proliferation and suppresses catabolic processes, such as macroautophagy/autophagy. These effects are mediated by checkpoint kinases such as MTOR (mechanistic target of rapamycin kinase), which is ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1783119
更新日期:2020-07-05 00:00:00
abstract::Neuroepithelial cells undergoing differentiation efficiently remodel their cytoskeleton and shape in an energy-consuming process. The capacity of autophagy to recycle cellular components and provide energy could fulfill these requirements, thus supporting differentiation. However, little is known regarding the role of...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.8.2.18535
更新日期:2012-02-01 00:00:00
abstract::Chronic drinking leads to myocardial contractile dysfunction where ethanol metabolism plays an essential role. Acetaldehyde, the main ethanol metabolite, mediates alcohol-induced cell injury although the underlying mechanism is still elusive. This study was designed to examine the mechanism involved in accelerated eth...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.18997
更新日期:2012-04-01 00:00:00
abstract::In macroautophagy (hereafter autophagy), a morphological hallmark is the formation of double-membrane vesicles called autophagosomes that sequester and deliver cytoplasmic components to the lysosome/vacuole for degradation. This process begins with an initial sequestering compartment, the phagophore, which expands int...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.7.13009
更新日期:2010-10-01 00:00:00
abstract::Neurons are highly polarized cells composed of two distinct domains, the axon and the somatodendritic domain. Although AMPA-type glutamate receptors, which mediate fast excitatory neurotransmission in the vertebrate CNS, are preferentially expressed in the somatodendritic domain, the molecular mechanisms underlying su...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6493
更新日期:2008-08-01 00:00:00
abstract::Atg18p and Atg21p are two highly homologous yeast autophagy proteins. Atg18p functions in both autophagy and the selective Cvt-pathway, while the function of Atg21p is restricted to the Cvt-pathway. The yeast genome encodes with Ygr223cp (Hsv2p), a third member of this protein family. So far no function has been assig...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6801
更新日期:2008-10-01 00:00:00
abstract::The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) and the enzyme that produces it, SPHK1 (sphingosine kinase 1), regulate many processes important for the etiology of cancer. It has been suggested that SPHK1 levels are regulated by the tumor suppressor protein TP53, a key regulator of cell cycle arre...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2018.1429875
更新日期:2018-01-01 00:00:00
abstract::We have reported in a variety of mammalian cells the reversible formation of a filamentous actin (F-actin)-enriched aggresome generated by the actin toxin jasplakinolide (Lázaro-Diéguez et al., J Cell Sci 2008; 121:1415-25). Notably, this F-actin aggresome (FAG) resembles in many aspects the pathological Hirano body, ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6345
更新日期:2008-07-01 00:00:00
abstract::The N-terminal amino acid of a protein is an essential determinant of ubiquitination and subsequent proteasomal degradation in the N-end rule pathway. Using para-chloroamphetamine (PCA), a specific inhibitor of the arginylation branch of the pathway (Arg/N-end rule pathway), we identified that blocking the Arg/N-end r...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1222991
更新日期:2016-11-01 00:00:00
abstract::The Atg8-family proteins are subdivided into two subfamilies: the GABARAP and LC3 subfamilies. These proteins, which are major players of the autophagy pathway, present a conserved glycine in their C-terminus necessary for their association to the autophagosome membrane. This family of proteins present multiple roles ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1749367
更新日期:2020-04-19 00:00:00