The MTOR signaling pathway regulates macrophage differentiation from mouse myeloid progenitors by inhibiting autophagy.

abstract：:FTY720, a sphingosine analog, is a novel immunosuppressant currently undergoing multiple clinical trials for the prevention of organ transplant rejection and treatment of various autoimmune diseases. Recent studies indicate an additional cytotoxic effect of FTY720 and its preclinical efficacy in a variety of cancer mo...

journal_title：Autophagy

authors： Zhang N,Qi Y,Wadham C,Wang L,Warren A,Di W,Xia P

更新日期：2010-11-01 00:00:00

abstract：:Phosphoinositides (PIs) are a group of low-abundance phospholipids that play a critical role in the control of organelle and membrane traffic. There is strong evidence that specific PIs are also important for the regulation of autophagy. PIs are modified by a complex network of lipid kinases and phosphatases. A recent...

journal_title：Autophagy

authors： Gibbs EM,Feldman EL,Dowling JJ

更新日期：2010-08-01 00:00:00

abstract：:Autophagy is involved in cellular clearance of aggregate-prone proteins, thereby having a cytoprotective function. Studies in yeast have shown that the PI 3-kinase Vps34 and its regulatory protein kinase Vps15 are important for autophagy, but the possible involvement of these proteins in autophagy in a multicellular a...

journal_title：Autophagy

authors： Lindmo K,Brech A,Finley KD,Gaumer S,Contamine D,Rusten TE,Stenmark H

更新日期：2008-05-01 00:00:00

abstract：:Atg13 is an essential subunit of the Atg1 autophagy initiation complex in yeast and its mammalian counterpart, ATG13, is indispensable for autophagy induction by the ULK1 complex. The N terminus of the protein folds into a HORMA domain, an architecture that has been revealed by crystallography. 1-4 In human cells, the...

journal_title：Autophagy

authors： Popelka H,Klionsky DJ

更新日期：2017-03-04 00:00:00

abstract：:During reticulocyte maturation, hematopoietic progenitors undergo numerous changes to reach the final functional stage which concludes with the release of reticulocytes and erythrocytes into circulation. During this process some proteins, which are not required in the mature stage, are sequestered in the internal vesi...

journal_title：Autophagy

authors： Fader CM,Colombo MI

更新日期：2006-04-01 00:00:00

abstract：:Drawing as a way of understanding things better/easier is in human nature, from textbook images through the models and graphical abstracts published in scientific papers to chalk talks during the academic job interview process. As a molecular cell biologist and geneticist, I always find it easier to show a microscopy ...

journal_title：Autophagy

authors： Juhász G

更新日期：2019-11-01 00:00:00

abstract：:Ultraviolet (UV)-induced DNA damage is a major risk factor for skin cancers including melanoma. UVRAG, originally identified to complement UV sensitivity in xeroderma pigmentosum (XP), has since been implicated in modulating macroautophagy/autophagy, in coordinating different intracellular trafficking pathways, and in...

journal_title：Autophagy

authors： Yang Y,Quach C,Liang C

更新日期：2016-09-01 00:00:00

abstract：:The two structurally related, major lysosomal membrane proteins LAMP-1 and LAMP-2 were for a long time regarded as crucial for the protection of the lysosomal membrane from the hostile lumenal environment. However, recent studies on the effects of single and combined LAMP-deficiency in mice reveal alternative function...

journal_title：Autophagy

authors： Saftig P,Beertsen W,Eskelinen EL

更新日期：2008-05-01 00:00:00

abstract：:The lysosome is a key subcellular organelle that receives and degrades macromolecules from endocytic, secretory and autophagic pathways. Lysosomal function is thus critical for an efficient autophagic process. However, the molecular mechanisms mediating lysosomal function upon autophagic induction are largely unknown....

journal_title：Autophagy

authors： Zhou J,Tan SH,Codogno P,Shen HM

更新日期：2013-05-01 00:00:00

abstract：:Combining two different treatment modalities for targeting malignancies is gaining importance, with preclinical/clinical results indicating higher success rates in eradicating tumors or having longer remission periods. A better understanding of the synergy between the treatments helps in optimizing the dose and time o...

journal_title：Autophagy

authors： Ramakrishnan R,Gabrilovich DI

更新日期：2013-04-01 00:00:00

abstract：:Macroautophagy/autophagy is an important catabolic process for maintaining cellular homeostasis by adapting to various stress conditions. Autophagy is mediated by a double-membrane autophagosome, which sequesters a portion of cytoplasmic components for delivery to the vacuole. Several autophagy-related (ATG) genes pla...

journal_title：Autophagy

authors： Kim B,Lee Y,Choi H,Huh WK

更新日期：2020-04-02 00:00:00

abstract：:Efavirenz (EFV) is the most widely used non-nucleoside reverse transcriptase inhibitor applied in highly active antiretroviral therapy (HAART), the combined pharmacological treatment of the human immunodeficiency virus infection. Its use has been associated with the development of several adverse events including hepa...

journal_title：Autophagy

authors： Apostolova N,Gomez-Sucerquia LJ,Gortat A,Blas-Garcia A,Esplugues JV

更新日期：2011-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the consequence of chronic liver damage caused by the excessive generation of reactive oxygen species (ROS). To mitigate the deleterious effects of ROS, cells activate the transcription factor NFE2L2/NRF2, which is constitutively degraded through its partner KEAP1. The inactivation of...

journal_title：Autophagy

authors： Moscat J,Diaz-Meco MT

更新日期：2020-10-01 00:00:00

abstract：:The Pacific oyster, Crassostrea gigas, is a mollusk bivalve commercially important as a food source. Pacific oysters are subjected to stress and diseases during culture. The autophagy pathway is involved in numerous cellular processes, including responses to starvation, cell death, and microorganism elimination. Autop...

journal_title：Autophagy

authors： Picot S,Faury N,Arzul I,Chollet B,Renault T,Morga B

更新日期：2020-11-01 00:00:00

abstract：:Mutations in the ER-associated VAPB/ALS8 protein cause amyotrophic lateral sclerosis and spinal muscular atrophy. Previous studies have argued that ER stress may underlie the demise of neurons. We find that loss of VAP proteins (VAPs) leads to an accumulation of aberrant lysosomes and impairs lysosomal degradation. VA...

journal_title：Autophagy

authors： Mao D,Lin G,Tepe B,Zuo Z,Tan KL,Senturk M,Zhang S,Arenkiel BR,Sardiello M,Bellen HJ

更新日期：2019-07-01 00:00:00

abstract：:There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria via a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We thus ...

journal_title：Autophagy

authors： Wu H,Wang Y,Li W,Chen H,Du L,Liu D,Wang X,Xu T,Liu L,Chen Q

更新日期：2019-11-01 00:00:00

abstract：:T lymphocytes, the master regulators of immunity, have an unusual lifestyle. Equipped with a clonally distributed receptor they remain resting for long periods of time but go into overdrive when encountering antigen. Antigen recognition triggers an activation program that results in massive proliferation, differentiat...

journal_title：Autophagy

authors： Yang Z,Goronzy JJ,Weyand CM

更新日期：2014-02-01 00:00:00

abstract：:Lysosomal storage diseases (LSDs) are debilitating genetic conditions that frequently manifest as neurodegenerative disorders. They severely affect eye, motor and cognitive functions and, in most cases, abbreviate the lifespan. Postmitotic cells such as neurons and mononuclear phagocytes rich in lysosomes are most oft...

journal_title：Autophagy

authors： Kiselyov K,Jennigs JJ Jr,Rbaibi Y,Chu CT

更新日期：2007-05-01 00:00:00

abstract：:The etiological agent for anthrax is Bacillus anthracis, which produces lethal toxin (LT) that exerts a myriad of effects on many immune cells. In our previous study, it was demonstrated that LT and protective antigen (PA) induce autophagy in mammalian cells. Preliminary results suggest that autophagy may function as ...

journal_title：Autophagy

authors： Tan YK,Vu HA,Kusuma CM,Wu A

更新日期：2009-07-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the two most important components of cellular mechanisms for protein degradation. In the present study we investigated the functional relationship of the two systems and the interactional role of p53 in vitro. Our study showed that the...

journal_title：Autophagy

authors： Du Y,Yang D,Li L,Luo G,Li T,Fan X,Wang Q,Zhang X,Wang Y,Le W

更新日期：2009-07-01 00:00:00

abstract：:Proteome profiling and global protein-interaction approaches have significantly improved our knowledge of the protein interactomes of autophagy and other cellular stress-response pathways. New discoveries regarding protein complexes, interaction partners, interaction domains, and biological roles of players that are p...

journal_title：Autophagy

authors： Ho CJ,Samarasekera G,Rothe K,Xu J,Yang KC,Leung E,Chan M,Jiang X,Gorski SM

更新日期：2020-06-07 00:00:00

abstract：:Salinomycin is perhaps the first promising compound that was discovered through high throughput screening in cancer stem cells. This novel agent can selectively eliminate breast and other cancer stem cells, though the mechanism of action remains unclear. In this study, we found that salinomycin induced autophagy in hu...

journal_title：Autophagy

authors： Li T,Su L,Zhong N,Hao X,Zhong D,Singhal S,Liu X

更新日期：2013-07-01 00:00:00

abstract：:Autophagy is a catabolic process employed by eukaryotes to degrade and recycle intracellular components. When this pathway is induced by starvation conditions, part of the cytoplasm and organelles are sequestered into double-membrane vesicles called autophagosomes, and delivered into the lysosome/vacuole for degradati...

journal_title：Autophagy

authors： Monastyrska I,Reggiori F,Klionsky DJ

更新日期：2008-10-01 00:00:00

abstract：:As a highly dynamic organelle, mitochondria undergo constitutive fusion and fission as well as biogenesis and degradation. Mitophagy, selective mitochondrial degradation through autophagy, is a conserved cellular process used for the elimination of excessive and damaged mitochondria in eukaryotes. Despite the signific...

journal_title：Autophagy

authors： Mao K,Klionsky DJ

更新日期：2013-11-01 00:00:00

abstract：:Ferroptosis is a recently discovered form of programmed cell death, but its regulatory mechanisms remain poorly understood. Here, we show that the RNA-binding protein ZFP36/TTP (ZFP36 ring finger protein) plays a crucial role in regulating ferroptosis in hepatic stellate cells (HSCs). Upon exposure to ferroptosis-indu...

journal_title：Autophagy

authors： Zhang Z,Guo M,Li Y,Shen M,Kong D,Shao J,Ding H,Tan S,Chen A,Zhang F,Zheng S

更新日期：2020-08-01 00:00:00

abstract：:Autophagy genes were first identified in the yeast system and some of their mammalian orthologues have also been characterized. Increasing lines of evidence indicate that various intracellular proteins, including G proteins, mammalian target of rapamycin (mTor) and Pl3K/Akt/PKB, of transmembrane signaling pathways are...

journal_title：Autophagy

authors： Jia G,Cheng G,Agrawal DK

更新日期：2007-01-01 00:00:00

abstract：:The link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-rich repeat kinase 2 (LR...

journal_title：Autophagy

authors： Bravo-San Pedro JM,Gómez-Sánchez R,Niso-Santano M,Pizarro-Estrella E,Aiastui-Pujana A,Gorostidi A,Climent V,López de Maturana R,Sanchez-Pernaute R,López de Munain A,Fuentes JM,González-Polo RA

更新日期：2012-10-01 00:00:00

abstract：:Reactive oxygen species (ROS) that accumulate under oxidative pressure cause severe damage to cellular components, and induce various cellular responses, including apoptosis, programmed necrosis and autophagy, depending on the cellular setting. Various studies have described ROS-induced autophagy, but only a few direc...

journal_title：Autophagy

authors： Eisenberg-Lerner A,Kimchi A

更新日期：2012-03-01 00:00:00

abstract：:The vascular system of plants consists of two conducting tissues, xylem and phloem, which differentiate from procambium cells. Xylem serves as a transporting system for water and signaling molecules and is formed by sequential developmental processes, including cell division/expansion, secondary cell wall deposition, ...

journal_title：Autophagy

authors： Kwon SI,Cho HJ,Park OK

更新日期：2010-11-01 00:00:00

abstract：:The conserved target of rapamycin (TOR) kinase is a central regulator of cell growth in response to nutrient availability. TOR forms 2 structurally and functionally distinct complexes, TORC1 and TORC2, and negatively regulates autophagy via TORC1. Here we demonstrate TOR also operates independently through the TORC2 s...

journal_title：Autophagy

authors： Vlahakis A,Powers T

更新日期：2014-01-01 00:00:00