PKD at the crossroads of necrosis and autophagy.

abstract：:Lafora disease (LD) is an inherited and fatal form of neurodegenerative disorder characterized by the presence of an abnormal form of glycogen inclusions, called Lafora bodies, in neurons and other tissues. While Lafora bodies have been thought to underlie the neuropathology in LD, the specific process by which these ...

journal_title：Autophagy

authors： Puri R,Ganesh S

更新日期：2012-02-01 00:00:00

abstract：:The uptake and degradation of cytoplasmic material by vacuolar autophagy in plants has been studied extensively by electron microscopy and shown to be involved in developmental processes such as vacuole formation, deposition of seed storage proteins and senescence, and in the response of plants to nutrient starvation ...

journal_title：Autophagy

authors： Bassham DC,Laporte M,Marty F,Moriyasu Y,Ohsumi Y,Olsen LJ,Yoshimoto K

更新日期：2006-01-01 00:00:00

abstract：:SNCA/α-synuclein aggregation plays a crucial role in synucleinopathies such as Parkinson disease and dementia with Lewy bodies. Aggregating and nonaggregating SNCA species are degraded by the autophagy-lysosomal pathway (ALP). Previously, we have shown that the ALP is not only responsible for SNCA degradation but is a...

journal_title：Autophagy

authors： Poehler AM,Xiang W,Spitzer P,May VE,Meixner H,Rockenstein E,Chutna O,Outeiro TF,Winkler J,Masliah E,Klucken J

更新日期：2014-01-01 00:00:00

abstract：:In a recent study, we reported in vivo evidence of early and sustained alterations of autophagy markers in a novel knock-in mouse model of Huntington disease (HD). The novel model is derived from selective breeding of HdhQ150 knock-in mice to generate mice with ~200 CAG/polyglutamine repeats (HdhQ200). HdhQ200 knockin...

journal_title：Autophagy

authors： Heng MY,Detloff PJ,Paulson HL,Albin RL

更新日期：2010-11-01 00:00:00

abstract：:Ferroptosis is a form of regulated cell death caused by iron accumulation and oxidative injury. BECN1 is a key regulator of macroautophagy/autophagy, a catabolic process of degradation induced by starvation or other stressors. Our recent findings reveal a novel alternative mechanism by which BECN1 can promote ferropto...

journal_title：Autophagy

authors： Kang R,Zhu S,Zeh HJ,Klionsky DJ,Tang D

更新日期：2018-01-01 00:00:00

abstract：:Thioglycolate-elicited macrophages exhibit abundant conjugation of LC3 with PE (LC3-II). Among other autophagy-related (ATG) proteins, it is proposed that, like in yeast, both ATG5 and ATG7 are essential for LC3 conjugation. Using atg5-deficient ( -/- ) and atg7-/- macroph...

journal_title：Autophagy

authors： Vujić N,Bradić I,Goeritzer M,Kuentzel KB,Rainer S,Kratky D,Radović B

更新日期：2021-01-18 00:00:00

abstract：:Antagonizing the strongly activated pathway of autophagy in renal ischemic injury has been associated with poor outcome. In our recent study we used mice with a selective deletion of Atg5 in the S3 proximal tubule segment, which is most susceptible to ischemic damage. In line with the notion that autophagy is a prosur...

journal_title：Autophagy

authors： Melk A,Baisantry A,Schmitt R

更新日期：2016-01-01 00:00:00

abstract：:Autophagy or Type II programmed cell death (PCD) is a major intracellular pathway for the degradation and recycling of proteins, ribosomes and entire organelles. The role of this pathway in the antitumor effect of radiotherapy and in radiation toxicity is obscure. A complicated machinery of genes and proteins is invol...

journal_title：Autophagy

authors： Zois CE,Koukourakis MI

更新日期：2009-05-01 00:00:00

abstract：:A shared neuropathological hallmark in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is nuclear clearance and cytoplasmic aggregation of TARDBP/TDP-43 (TAR DNA binding protein). We previously showed that the ability of TARDBP to repress nonconserved cryptic exons was impaired in brains of patie...

journal_title：Autophagy

authors： Donde A,Sun M,Jeong YH,Wen X,Ling J,Lin S,Braunstein K,Nie S,Wang S,Chen L,Wong PC

更新日期：2020-04-01 00:00:00

abstract：:The conserved target of rapamycin (TOR) kinase is a central regulator of cell growth in response to nutrient availability. TOR forms 2 structurally and functionally distinct complexes, TORC1 and TORC2, and negatively regulates autophagy via TORC1. Here we demonstrate TOR also operates independently through the TORC2 s...

journal_title：Autophagy

authors： Vlahakis A,Powers T

更新日期：2014-01-01 00:00:00

abstract：:The understanding of the membrane flow process during autophagosome formation is essential to illuminate the role of autophagy under various disease-causing conditions. Atg9 is the only identified integral membrane protein required for autophagosome formation, and it is thought to cycle between the membrane sources an...

journal_title：Autophagy

authors： He C,Baba M,Klionsky DJ

更新日期：2009-04-01 00:00:00

abstract：:In almost all animals, mitochondrial DNA (mtDNA) is transmitted only from the female, while the paternal mitochondria and mtDNA are thought to be eliminated during early embryogenesis. Autophagy is involved in the elimination of sperm mitochondria and mtDNA in early embryos in Caenorhabditis elegans; however, solid ev...

journal_title：Autophagy

authors： Luo SM,Sun QY

更新日期：2013-12-01 00:00:00

abstract：:Although Beclin 1 and mTOR are considered to be the main molecules to modulate the autophagic process, searching for other autophagy-regulating molecules is still an ongoing challenge to scientists. Here we demonstrated that FoxO1, a forkhead O family protein, is a mediator of autophagy. Upon oxidative stress or serum...

journal_title：Autophagy

authors： Zhao Y,Wang L,Yang J,Zhang P,Ma K,Zhou J,Liao W,Zhu WG

更新日期：2010-10-01 00:00:00

abstract：:ATM (ataxia telangiectasia mutated) protein is found associated with multiple organelles including synaptic vesicles, endosomes and lysosomes, often in cooperation with ATR (ataxia telangiectasia and Rad3 related). Mutation of the ATM gene results in ataxia-telangiectasia (A-T), an autosomal recessive disorder with de...

journal_title：Autophagy

authors： Cheng A,Tse KH,Chow HM,Gan Y,Song X,Ma F,Qian YXY,She W,Herrup K

更新日期：2020-08-14 00:00:00

abstract：:One of the major side effects of cisplatin chemotherapy is toxic acute kidney injury due to preferential accumulation of cisplatin in renal proximal tubule epithelial cells and the subsequent injury to these cells. Apoptosis is known as a major mechanism of cisplatin-induced cell death in renal tubular cells. We have ...

journal_title：Autophagy

authors： Kaushal GP,Kaushal V,Herzog C,Yang C

更新日期：2008-07-01 00:00:00

abstract：:Heme is an essential molecule expressed in many tissues where it plays key roles as the prosthetic group of several proteins involved in vital physiological and metabolic processes such as gas and electron transport. Structurally, heme is a tetrapyrrole ring containing an atom of iron (Fe) in its center. When released...

journal_title：Autophagy

authors： Travassos LH,Vasconcellos LR,Bozza MT,Carneiro LA

更新日期：2017-03-04 00:00:00

abstract：:In 2013, Dr. Lora Hooper and colleagues described the induction of antibacterial macroautophagy/autophagy in intestinal epithelial cells as a cytoprotective host defense mechanism against invading Salmonella enterica serovar Typhimurium (S. Typhimurium). Canonical autophagy functions in a primarily degradative capacit...

journal_title：Autophagy

authors： Delorme-Axford E,Klionsky DJ

更新日期：2018-01-01 00:00:00

abstract：:The upregulation of autophagosome formation in response to nutrient deprivation requires significant intracellular membrane rearrangements that are poorly understood. Recent findings have implicated COPII-coated vesicles, well known as ER-Golgi cargo transport carriers, as key players in macroautophagy. The role of CO...

journal_title：Autophagy

authors： Wang J,Davis S,Zhu M,Miller EA,Ferro-Novick S

更新日期：2017-05-04 00:00:00

abstract：:Macroautophagy/autophagy occurs at basal levels in all eukaryotic cells and plays an important role in maintaining bio-energetic homeostasis through the control of molecule degradation and organelle turnover. It can be induced by environmental conditions such as starvation, and is deregulated in many diseases includin...

journal_title：Autophagy

authors： Ceccariglia S,Cargnoni A,Silini AR,Parolini O

更新日期：2020-01-01 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis, a tropical infection of humans and other animals. The bacterium is an intracellular pathogen that can escape from endosomes into the host cytoplasm, where it replicates and infects adjacent cells. We investigated the role played by autophagy in the intra...

journal_title：Autophagy

authors： Cullinane M,Gong L,Li X,Lazar-Adler N,Tra T,Wolvetang E,Prescott M,Boyce JD,Devenish RJ,Adler B

更新日期：2008-08-01 00:00:00

abstract：:Microtubule-associated protein light chain 3 (LC3) is now widely used to monitor autophagy. One approach is to detect LC3 conversion (LC3-I to LC3-II) by immunoblot analysis because the amount of LC3-II is clearly correlated with the number of autophagosomes. However, LC3-II itself is degraded by autophagy, making int...

journal_title：Autophagy

authors： Mizushima N,Yoshimori T

更新日期：2007-11-01 00:00:00

abstract：:Tumor hypoxia underlies treatment failure and yields more aggressive and metastatic cancer phenotypes. Although therapeutically targeting these hypoxic environments has been proposed for many years, to date no approaches have shown the therapeutic value to gain regulatory approval. Here, we demonstrated that a novel h...

journal_title：Autophagy

authors： Liu XW,Cai TY,Zhu H,Cao J,Su Y,Hu YZ,He QJ,Yang B

更新日期：2014-01-01 00:00:00

abstract：:Oxidative stress (OS) stimulates autophagy in different cellular systems, but it remains controversial if this rule can be generalized. We have analyzed the effect of chronic OS induced by the parkinsonian toxin paraquat (PQ) on autophagy in astrocytoma cells and primary astrocytes, which represent the first cellular ...

journal_title：Autophagy

authors： Janda E,Lascala A,Carresi C,Parafati M,Aprigliano S,Russo V,Savoia C,Ziviani E,Musolino V,Morani F,Isidoro C,Mollace V

更新日期：2015-01-01 00:00:00

abstract：:Regulated degradation of cellular components by lysosomes is essential to maintain biological homeostasis. In mammals, three forms of autophagy, macroautophagy, microautophagy and chaperone-mediated autophagy (CMA), have been identified. Here, we showed a novel type of autophagy, in which RNA is taken up directly into...

journal_title：Autophagy

authors： Fujiwara Y,Furuta A,Kikuchi H,Aizawa S,Hatanaka Y,Konya C,Uchida K,Yoshimura A,Tamai Y,Wada K,Kabuta T

更新日期：2013-03-01 00:00:00

abstract：:Macroautophagy/autophagy is the main intracellular catabolic pathway in neurons that eliminates misfolded proteins, aggregates and damaged organelles associated with ageing and neurodegeneration. Autophagy is regulated by both MTOR-dependent and -independent pathways. There is increasing evidence that autophagy is com...

journal_title：Autophagy

authors： Perera ND,Sheean RK,Lau CL,Shin YS,Beart PM,Horne MK,Turner BJ

更新日期：2018-01-01 00:00:00

abstract：:Neuroepithelial cells undergoing differentiation efficiently remodel their cytoskeleton and shape in an energy-consuming process. The capacity of autophagy to recycle cellular components and provide energy could fulfill these requirements, thus supporting differentiation. However, little is known regarding the role of...

journal_title：Autophagy

authors： Vázquez P,Arroba AI,Cecconi F,de la Rosa EJ,Boya P,de Pablo F

更新日期：2012-02-01 00:00:00

abstract：:Cargo-based assays have proven invaluable in the study of macroautophagy in yeast and mammalian cells. Proteomic analysis of autolysosomes identified the metabolic enzyme, betaine homocysteine methyltransferase (BHMT), as a potential cargo-based, end-point marker for mammalian macroautophagy. To test whether degradati...

journal_title：Autophagy

authors： Mercer CA,Kaliappan A,Dennis PB

更新日期：2008-02-01 00:00:00

abstract：:Most autophagy-related (Atg) proteins are assembled at the phagophore assembly site or pre-autophagosomal structure (PAS), which is a potential site for vesicle formation during vegetative or starvation conditions. To understand the initial step of vesicle formation, it is important to know how Atg proteins are recrui...

journal_title：Autophagy

authors： Cheong H,Klionsky DJ

更新日期：2008-07-01 00:00:00

abstract：:Autophagy acts as an intrinsic defense system against intracellular bacterial survival. Recently, multiple cellular pathways that target intracellular bacterial pathogens to autophagy have been described. These include the Atg5/LC3 pathway, which targets Shigella, the ubiquitin (Ub)-NDP52-LC3 pathway, which targets Gr...

journal_title：Autophagy

authors： Ogawa M,Yoshikawa Y,Mimuro H,Hain T,Chakraborty T,Sasakawa C

更新日期：2011-03-01 00:00:00

abstract：:Under stress conditions cells activate different response pathways which result in cell survival or apoptosis depending on: (1) the nature of the insults, (2) the type, if acute or chronic stress, and (3) how long the stress persists. Generally, autophagy is induced early to sustain cell survival and inhibit cell deat...

journal_title：Autophagy

authors： Corazzari M,Fimia GM,Piacentini M

更新日期：2012-08-01 00:00:00