Heme and iron induce protein aggregation.

abstract：:The lack of a rapid and quantitative autophagy assay has substantially hindered the development and implementation of autophagy-targeting therapies for a variety of human diseases. To address this critical issue, we developed a novel autophagy assay using the newly developed Cyto-ID fluorescence dye. We first verified...

journal_title：Autophagy

authors： Guo S,Liang Y,Murphy SF,Huang A,Shen H,Kelly DF,Sobrado P,Sheng Z

更新日期：2015-01-01 00:00:00

abstract：:Silver nanoparticles (Ag NPs) are cytotoxic to cancer cells and possess excellent potential as an antitumor agent. A variety of nanoparticles have been shown to induce autophagy, a critical cellular degradation process, and the elevated autophagy in most of these situations promotes cell death. Whether Ag NPs can indu...

journal_title：Autophagy

authors： Lin J,Huang Z,Wu H,Zhou W,Jin P,Wei P,Zhang Y,Zheng F,Zhang J,Xu J,Hu Y,Wang Y,Li Y,Gu N,Wen L

更新日期：2014-01-01 00:00:00

abstract：:ULK1 (unc-51 like autophagy activating kinase 1), the key mediator of MTORC1 signaling to autophagy, regulates early stages of autophagosome formation in response to starvation or MTORC1 inhibition. How ULK1 regulates the autophagy induction process remains elusive. Here, we identify that ATG13, a binding partner of U...

journal_title：Autophagy

authors： Park JM,Jung CH,Seo M,Otto NM,Grunwald D,Kim KH,Moriarity B,Kim YM,Starker C,Nho RS,Voytas D,Kim DH

更新日期：2016-01-01 00:00:00

abstract：:Single microRNA (miRNA) can regulate expression of several or multiple principal targets in a specific microenvironment. In different cellular contexts, the same miRNA may exhibit diverse functions, depending on the repertoire and stoichiometry of its direct mRNA targets. For instance, in breast cancer, microRNA-10b (...

journal_title：Autophagy

authors： Gabriely G,Teplyuk NM,Krichevsky AM

更新日期：2011-11-01 00:00:00

abstract：:Infection and inflammation are able to induce diet-independent Na+-accumulation without commensurate water retention in afflicted tissues, which favors the pro-inflammatory activation of mouse macrophages and augments their antibacterial and antiparasitic activity. While Na+-boosted host defense against the protozoan ...

journal_title：Autophagy

authors： Neubert P,Weichselbaum A,Reitinger C,Schatz V,Schröder A,Ferdinand JR,Simon M,Bär AL,Brochhausen C,Gerlach RG,Tomiuk S,Hammer K,Wagner S,van Zandbergen G,Binger KJ,Müller DN,Kitada K,Clatworthy MR,Kurts C,Titze J,

更新日期：2019-11-01 00:00:00

abstract：:The Atg8-family proteins are subdivided into two subfamilies: the GABARAP and LC3 subfamilies. These proteins, which are major players of the autophagy pathway, present a conserved glycine in their C-terminus necessary for their association to the autophagosome membrane. This family of proteins present multiple roles ...

journal_title：Autophagy

authors： Jacquet M,Guittaut M,Fraichard A,Despouy G

更新日期：2020-04-19 00:00:00

abstract：:Macroautophagy/autophagy dysfunction is associated with many neurodegenerative diseases. TFEB (transcription factor EB), an important molecule that regulates lysosomal and autophagy function, is regarded as a potential target for treating some neurodegenerative diseases. However, the relationship between autophagy dys...

journal_title：Autophagy

authors： Ye B,Wang Q,Hu H,Shen Y,Fan C,Chen P,Ma Y,Wu H,Xiang M

更新日期：2019-06-01 00:00:00

abstract：:Autophagy or Type II programmed cell death (PCD) is a major intracellular pathway for the degradation and recycling of proteins, ribosomes and entire organelles. The role of this pathway in the antitumor effect of radiotherapy and in radiation toxicity is obscure. A complicated machinery of genes and proteins is invol...

journal_title：Autophagy

authors： Zois CE,Koukourakis MI

更新日期：2009-05-01 00:00:00

abstract：:Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fa...

journal_title：Autophagy

authors： Dorn GW 2nd

更新日期：2016-01-01 00:00:00

abstract：:Mitochondrial morphological and structural changes play a role in several cellular processes, including apoptosis. We recently reported that mitochondrial elongation is also critical to sustain cell viability during macroautophagy. During macroautophagy unopposed mitochondrial fusion leads to organelle elongation both...

journal_title：Autophagy

authors： Gomes LC,Scorrano L

更新日期：2011-10-01 00:00:00

abstract：:Delivery of cellular contents to yeast vacuoles/mammalian lysosomes via autophagy ensures long-term cell survival and extends life span. When cultured yeast cells are grown for a prolonged period of time to enter stationary phase, a nondividing state mimicking quiescence, vacuolar membrane proteins partition into eith...

journal_title：Autophagy

authors： Wang CW

更新日期：2014-01-01 00:00:00

abstract：:ULK1 and ATG13 assemble with RB1CC1/FIP200 and ATG101 to form a macroautophagy (hereafter autophagy) induction (ULK1) complex in higher eukaryotes. The yeast counterpart, the Atg1 complex, is comprised of Atg1 and Atg13 (ULK1 and ATG13 homologs), Atg17 (a proposed functional homolog of RB1CC1), and either the Atg101 s...

journal_title：Autophagy

authors： Popelka H,Klionsky DJ

更新日期：2015-11-02 00:00:00

abstract：:Protein synthesis and autophagy work as two opposing processes to control cell growth in response to nutrient supply. The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) pathway, which acts as a master regulator to control protein synthesis, has recently been shown to inhibit autophagy by phosphorylating ...

journal_title：Autophagy

authors： Dunlop EA,Hunt DK,Acosta-Jaquez HA,Fingar DC,Tee AR

更新日期：2011-07-01 00:00:00

abstract：:Regulated degradation of cellular components by lysosomes is essential to maintain biological homeostasis. In mammals, three forms of autophagy, macroautophagy, microautophagy and chaperone-mediated autophagy (CMA), have been identified. Here, we showed a novel type of autophagy, in which RNA is taken up directly into...

journal_title：Autophagy

authors： Fujiwara Y,Furuta A,Kikuchi H,Aizawa S,Hatanaka Y,Konya C,Uchida K,Yoshimura A,Tamai Y,Wada K,Kabuta T

更新日期：2013-03-01 00:00:00

abstract：:Under stress conditions cells activate different response pathways which result in cell survival or apoptosis depending on: (1) the nature of the insults, (2) the type, if acute or chronic stress, and (3) how long the stress persists. Generally, autophagy is induced early to sustain cell survival and inhibit cell deat...

journal_title：Autophagy

authors： Corazzari M,Fimia GM,Piacentini M

更新日期：2012-08-01 00:00:00

abstract：:Phosphoinositides (PIs) are a group of low-abundance phospholipids that play a critical role in the control of organelle and membrane traffic. There is strong evidence that specific PIs are also important for the regulation of autophagy. PIs are modified by a complex network of lipid kinases and phosphatases. A recent...

journal_title：Autophagy

authors： Gibbs EM,Feldman EL,Dowling JJ

更新日期：2010-08-01 00:00:00

abstract：:Damaged mitochondria are turned over through a process of selective autophagy termed mitophagy. In mitophagy, unhealthy mitochondria are recognized and ubiquitinated by Parkinson disease-linked proteins PINK1 and PARK2. The subsequent recruitment of ubiquitin-binding autophagy receptors leads in turn to the sequestrat...

journal_title：Autophagy

authors： Moore AS,Holzbaur EL

更新日期：2016-10-02 00:00:00

abstract：:Autophagy and apoptosis are 2 fundamental biological mechanisms that may cooperate or be antagonistic, although both are involved in deciding the fate of cells in physiological or pathological conditions. These 2 mechanisms coexist simultaneously in cells and share common upstream signals and stimuli. Autophagy and ap...

journal_title：Autophagy

authors： Ravegnini G,Sammarini G,Nannini M,Pantaleo MA,Biasco G,Hrelia P,Angelini S

更新日期：2017-03-04 00:00:00

abstract：:Autophagy has recently been implicated in the host defense against the intracellular protozoan pathogen, Toxoplasma gondii, a major opportunistic pathogen of the central nervous system in immunosuppressed individuals. In both IFN gamma-activated macrophages and astrocytes, the p47 GTPases traffic to the T. gondii para...

journal_title：Autophagy

authors： Halonen SK

更新日期：2009-02-01 00:00:00

abstract：:Although Beclin 1 and mTOR are considered to be the main molecules to modulate the autophagic process, searching for other autophagy-regulating molecules is still an ongoing challenge to scientists. Here we demonstrated that FoxO1, a forkhead O family protein, is a mediator of autophagy. Upon oxidative stress or serum...

journal_title：Autophagy

authors： Zhao Y,Wang L,Yang J,Zhang P,Ma K,Zhou J,Liao W,Zhu WG

更新日期：2010-10-01 00:00:00

abstract：:Ridding neurons of toxic misfolded proteins is a critical feature of many neurodegenerative diseases. We have recently reported that lack of access of nuclear polyglutamine-expanded androgen receptor (AR) to the autophagic degradation pathway is a critical point in pathogenesis. When mutant AR is contained within the ...

journal_title：Autophagy

authors： Montie HL,Merry DE

更新日期：2009-11-01 00:00:00

abstract：:Autophagosomes arise in yeast and animals from the sealing of a cup-shaped double-membrane precursor, the phagophore. The concerted action of about 30 evolutionarily conserved autophagy related (ATG) proteins lies at the core of this process. However, the mechanisms allowing phagophore generation and its differentiati...

journal_title：Autophagy

authors： Le Bars R,Marion J,Satiat-Jeunemaitre B,Bianchi MW

更新日期：2014-10-01 00:00:00

abstract：:In the fungal pathogen Fusarium oxysporum, vegetative hyphal fusion triggers nuclear mitotic division in the invading hypha followed by migration of a nucleus into the receptor hypha and degradation of the resident nucleus. Here we examined the role of autophagy in fusion-induced nuclear degradation. A search of the F...

journal_title：Autophagy

authors： Corral-Ramos C,Roca MG,Di Pietro A,Roncero MI,Ruiz-Roldán C

更新日期：2015-01-01 00:00:00

abstract：:Deficiency in decidualization has been widely regarded as an important cause of spontaneous abortion. Generalized decidualization also includes massive infiltration and enrichment of NK cells. However, the underlying mechanism of decidual NK (dNK) cell residence remains largely unknown. Here, we observe that the incre...

journal_title：Autophagy

authors： Lu H,Yang HL,Zhou WJ,Lai ZZ,Qiu XM,Fu Q,Zhao JY,Wang J,Li DJ,Li MQ

更新日期：2020-11-01 00:00:00

abstract：:Significant progress has been made over recent years in defining the normal progression and regulation of autophagy, particularly in cultured mammalian cells and yeast model systems. However, apart from a few notable exceptions, our understanding of the physiological roles of autophagy has lagged behind these advances...

journal_title：Autophagy

authors： Neufeld TP,Baehrecke EH

更新日期：2008-07-01 00:00:00

abstract：:Autophagy is a process by which cytoplasmic material is sequestered in a double-membrane vesicle destined for degradation. Nutrient deprivation stimulates the pathway and the number of autophagosomes in the cell increases in response to such stimulus. In the current report we have demonstrated that actin is necessary ...

journal_title：Autophagy

authors： Aguilera MO,Berón W,Colombo MI

更新日期：2012-11-01 00:00:00

abstract：:As a highly dynamic organelle, mitochondria undergo constitutive fusion and fission as well as biogenesis and degradation. Mitophagy, selective mitochondrial degradation through autophagy, is a conserved cellular process used for the elimination of excessive and damaged mitochondria in eukaryotes. Despite the signific...

journal_title：Autophagy

authors： Mao K,Klionsky DJ

更新日期：2013-11-01 00:00:00

abstract：:Mitochondria are the primary site of energy production in animal cells. In mitochondria, the flow of electrons through the electron transport chain creates a potential difference across the inner membrane, which is utilized for ATP production. However, due to inherent inefficiencies in electron transport, reactive oxy...

journal_title：Autophagy

authors： Zhang J,Ney PA

更新日期：2010-04-01 00:00:00

abstract：:One of the main unanswered questions regarding the early steps of macroautophagy/autophagy is the mechanism of membrane-modeling events required for autophagosome formation. Three independent studies have recently revealed an actin cytoskeleton involvement in this process, providing significant details regarding the r...

journal_title：Autophagy

authors： Zientara-Rytter K,Subramani S

更新日期：2016-12-01 00:00:00

abstract：:In 2013, Dr. Lora Hooper and colleagues described the induction of antibacterial macroautophagy/autophagy in intestinal epithelial cells as a cytoprotective host defense mechanism against invading Salmonella enterica serovar Typhimurium (S. Typhimurium). Canonical autophagy functions in a primarily degradative capacit...

journal_title：Autophagy

authors： Delorme-Axford E,Klionsky DJ

更新日期：2018-01-01 00:00:00