The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14.

abstract：:Significant progress has been made over recent years in defining the normal progression and regulation of autophagy, particularly in cultured mammalian cells and yeast model systems. However, apart from a few notable exceptions, our understanding of the physiological roles of autophagy has lagged behind these advances...

journal_title：Autophagy

authors： Neufeld TP,Baehrecke EH

更新日期：2008-07-01 00:00:00

abstract：:A steady increase in life expectancy has resulted in an equivalent increase in elderly patients who are more susceptible to diseases than young patients. In a recent study, we found that in both in vitro and in vivo models of ischemia/reperfusion (I/R), a loss of ATG4B is causatively associated with the increased sens...

journal_title：Autophagy

authors： Wang JH,Behrns KE,Leeuwenburgh C,Kim JS

更新日期：2012-01-01 00:00:00

abstract：:Lafora disease (LD) is an inherited and fatal form of neurodegenerative disorder characterized by the presence of an abnormal form of glycogen inclusions, called Lafora bodies, in neurons and other tissues. While Lafora bodies have been thought to underlie the neuropathology in LD, the specific process by which these ...

journal_title：Autophagy

authors： Puri R,Ganesh S

更新日期：2012-02-01 00:00:00

abstract：:Proteins in eukaryotic cells are continually being degraded to amino acids either by the ubiquitin proteasome system (UPS) or by the autophagic-lysosomal pathway. The breakdown of proteins by these 2 degradative pathways involves totally different enzymes that function in distinct subcellular compartments. While most ...

journal_title：Autophagy

authors： Zhao J,Goldberg AL

更新日期：2016-10-02 00:00:00

abstract：:Salinomycin is perhaps the first promising compound that was discovered through high throughput screening in cancer stem cells. This novel agent can selectively eliminate breast and other cancer stem cells, though the mechanism of action remains unclear. In this study, we found that salinomycin induced autophagy in hu...

journal_title：Autophagy

authors： Li T,Su L,Zhong N,Hao X,Zhong D,Singhal S,Liu X

更新日期：2013-07-01 00:00:00

abstract：:Vascular endothelial cells (VECs) that form the inner wall of blood vessels can be injured by high glucose-induced autophagy and apoptosis. Although the role of long noncoding RNA in regulating cell fate has received widespread attention, long noncoding RNAs (lncRNAs) that can both regulate autophagy and apoptosis nee...

journal_title：Autophagy

authors： Zhao X,Su L,He X,Zhao B,Miao J

更新日期：2020-01-01 00:00:00

abstract：:The exploration into the roles of autophagy in tumorigenesis, either as tumor suppressor or tumor promoter, has led to a great increase in the knowledge of cancer development, progression and treatment. However, there is currently no consensus on how to manipulate autophagy to improve antitumor effects. In this study,...

journal_title：Autophagy

authors： Chang Y,Lin J,Tsung A

更新日期：2012-12-01 00:00:00

abstract：:Nanotechnology is the control and manipulation of materials in the size range of 1-100 nm. Due to increasing research into the potential beneficial applications of nanotechnology, there is an urgent need for the study of possible health risks. Several researchers, including those in our laboratory, have demonstrated e...

journal_title：Autophagy

authors： Stern ST,Johnson DN

更新日期：2008-11-01 00:00:00

abstract：:Inhibition of the autophagic pathway has recently revealed promising results in increasing pro-death activity of multiple cancer therapeutics. Here, we discuss our findings regarding the autophagy-blocking and anti-neoplastic effects of a synthetic sphingosine analog, FTY720, in mantle cell lymphoma (MCL). We also emp...

journal_title：Autophagy

authors： Alinari L,Baiocchi RA,Praetorius-Ibba M

更新日期：2012-03-01 00:00:00

abstract：:The vascular system of plants consists of two conducting tissues, xylem and phloem, which differentiate from procambium cells. Xylem serves as a transporting system for water and signaling molecules and is formed by sequential developmental processes, including cell division/expansion, secondary cell wall deposition, ...

journal_title：Autophagy

authors： Kwon SI,Cho HJ,Park OK

更新日期：2010-11-01 00:00:00

abstract：:Park2/Parkin is a central mediator of selective mitochondrial autophagy for mitochondrial quality control. We showed in mouse hearts that PINK1/Mfn2/Park2 mediated generalized mitophagy is essential to the normal perinatal transition from fetal mitochondria that prefer carbohydrates as metabolic substrates to adult fa...

journal_title：Autophagy

authors： Dorn GW 2nd

更新日期：2016-01-01 00:00:00

abstract：:The 4th International Symposium on Autophagy was held in Mishima, a small town between Tokyo and Kyoto, October 1-5, 2006 (http://isa4th.umin.jp/). The meeting was organized by the group of Eiki Kominami. Approximately 150 participants took part in this well-organized meeting in the spacious and comfortable Toray Conf...

journal_title：Autophagy

authors： Eskelinen EL,Deretic V,Neufeld T,Levine B,Cuervo AM

更新日期：2007-03-01 00:00:00

abstract：:Macroautophagy/autophagy is an important catabolic process for maintaining cellular homeostasis by adapting to various stress conditions. Autophagy is mediated by a double-membrane autophagosome, which sequesters a portion of cytoplasmic components for delivery to the vacuole. Several autophagy-related (ATG) genes pla...

journal_title：Autophagy

authors： Kim B,Lee Y,Choi H,Huh WK

更新日期：2020-04-02 00:00:00

abstract：:Neurons are highly polarized cells composed of two distinct domains, the axon and the somatodendritic domain. Although AMPA-type glutamate receptors, which mediate fast excitatory neurotransmission in the vertebrate CNS, are preferentially expressed in the somatodendritic domain, the molecular mechanisms underlying su...

journal_title：Autophagy

authors： Matsuda S,Yuzaki M

更新日期：2008-08-01 00:00:00

abstract：:Survival of environmental stress conditions requires the maintenance of cellular homeostasis. To preserve this balance, cells utilize a degradative mechanism known as autophagy. During this process, in response to starvation or other stresses, bulk cytoplasm is non-specifically sequestered within double-membrane vesic...

journal_title：Autophagy

authors： Legakis JE,Yen WL,Klionsky DJ

更新日期：2007-09-01 00:00:00

abstract：:To examine the functional significance and detailed morphological characteristics of starvation-induced autophagy in the adult heart, we starved green fluorescent protein (GFP)-microtubule-associated protein 1 light chain 3 (LC3) transgenic mice for up to 3 days. Electron microscopy revealed that, after as little as 1...

journal_title：Autophagy

authors： Takemura G,Kanamori H,Goto K,Maruyama R,Tsujimoto A,Fujiwara H,Seishima M,Minatoguchi S

更新日期：2009-10-01 00:00:00

abstract：N:6-methyladenosine (m6A), the most abundant internal modification on mRNAs in eukaryotes, play roles in adipogenesis. However, the underlying mechanism remains largely unclear. Here, we show that m6A plays a critical role in regulating macroautophagy/autophagy and adipogenesis through targeting Atg5 and Atg7. Mechanis...

journal_title：Autophagy

authors： Wang X,Wu R,Liu Y,Zhao Y,Bi Z,Yao Y,Liu Q,Shi H,Wang F,Wang Y

更新日期：2020-07-01 00:00:00

abstract：:Recent evidence suggests that autophagy may favor fibrosis through enhanced differentiation of fibroblasts in myofibroblasts. Here, we sought to characterize the mediators and signaling pathways implicated in autophagy-induced myofibroblast differentiation. Fibroblasts, serum starved for up to 4 d, showed increased LC...

journal_title：Autophagy

authors： Bernard M,Dieudé M,Yang B,Hamelin K,Underwood K,Hébert MJ

更新日期：2014-01-01 00:00:00

abstract：:The NIH-funded center for autophagy research named Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence, located at the University of New Mexico Health Science Center is now completing its second year as a working center with a mission to promote autophagy research locally, nationally...

journal_title：Autophagy

authors： Deretic V,Prossnitz E,Burge M,Campen MJ,Cannon J,Liu KJ,Liu M,Hall P,Sklar LA,Allers L,Mariscal L,Garcia SA,Weaver J,Baehrecke EH,Behrends C,Cecconi F,Codogno P,Chen GC,Elazar Z,Eskelinen EL,Fourie B,Gozuacik D

更新日期：2019-10-01 00:00:00

abstract：:DBI/ACBP (diazepam binding protein, acyl-CoA binding protein) participates in the regulation of fatty acid metabolism when it is localized within cells, whereas outside of cells it acts as a diazepam-binding protein. Recent results indicate that many different mammalian cell types release DBI/ACBP upon in vitro or in ...

journal_title：Autophagy

authors： Bravo-San Pedro JM,Sica V,Martins I,Anagnostopoulos G,Maiuri C,Kroemer G

更新日期：2019-11-01 00:00:00

abstract：:Nutrients not only act as building blocks but also as signaling molecules. Nutrient-availability promotes cell growth and proliferation and suppresses catabolic processes, such as macroautophagy/autophagy. These effects are mediated by checkpoint kinases such as MTOR (mechanistic target of rapamycin kinase), which is ...

journal_title：Autophagy

authors： Sanchez-Garrido J,Shenoy AR

更新日期：2020-07-05 00:00:00

abstract：:Loss of the lysosomal chloride transport protein ClC-7 leads to complex phenotypes in mice and man, including osteopetrosis, accumulation of lysosomal storage material, and neurodegeneration. Using novel tissue-specific ClC-7 knockout mice, we have shown that upon loss of ClC-7, lysosomal degradation of endocytosed pr...

journal_title：Autophagy

authors： Wartosch L,Stauber T

更新日期：2010-01-01 00:00:00

abstract：:Autophagy acts as an intrinsic defense system against intracellular bacterial survival. Recently, multiple cellular pathways that target intracellular bacterial pathogens to autophagy have been described. These include the Atg5/LC3 pathway, which targets Shigella, the ubiquitin (Ub)-NDP52-LC3 pathway, which targets Gr...

journal_title：Autophagy

authors： Ogawa M,Yoshikawa Y,Mimuro H,Hain T,Chakraborty T,Sasakawa C

更新日期：2011-03-01 00:00:00

abstract：:Radiation and conventional cytotoxic chemotherapies are ineffective in treating renal cancer. Approximately 75 percent of renal cell carcinoma (RCC) is associated with an inactivation of the tumor suppressor gene von Hippel-Lindau (VHL). We exploited the possibility of targeting VHL-deficient RCC through synthetic let...

journal_title：Autophagy

authors： Turcotte S,Sutphin PD,Giaccia AJ

更新日期：2008-10-01 00:00:00

abstract：:An increasing body of data links endoplasmic reticulum (ER) function to autophagy. Not surprisingly, then, some aberrant proteins in the ER can be destroyed either via ER associated degradation (ERAD), which is proteasome-mediated, or via autophagy. One such substrate is the "Z" variant of the alpha-1 protease inhibit...

journal_title：Autophagy

authors： Brodsky JL,Scott CM

更新日期：2007-11-01 00:00:00

abstract：:Autophagy is a catabolic process employed by eukaryotes to degrade and recycle intracellular components. When this pathway is induced by starvation conditions, part of the cytoplasm and organelles are sequestered into double-membrane vesicles called autophagosomes, and delivered into the lysosome/vacuole for degradati...

journal_title：Autophagy

authors： Monastyrska I,Reggiori F,Klionsky DJ

更新日期：2008-10-01 00:00:00

abstract：:The macroautophagy/autophagy-lysosome axis enables the clearance and degradation of cytoplasmic components including protein aggregates, damaged organelles and invading pathogens. Protein aggregation and lysosomal system dysfunction in the brain are common features of several late-onset neurological disorders includin...

journal_title：Autophagy

authors： Carosi JM,Hein LK,van den Hurk M,Adams R,Milky B,Singh S,Bardy C,Denton D,Kumar S,Sargeant TJ

更新日期：2020-09-22 00:00:00

abstract：:T lymphocytes, the master regulators of immunity, have an unusual lifestyle. Equipped with a clonally distributed receptor they remain resting for long periods of time but go into overdrive when encountering antigen. Antigen recognition triggers an activation program that results in massive proliferation, differentiat...

journal_title：Autophagy

authors： Yang Z,Goronzy JJ,Weyand CM

更新日期：2014-02-01 00:00:00

abstract：:In almost all animals, mitochondrial DNA (mtDNA) is transmitted only from the female, while the paternal mitochondria and mtDNA are thought to be eliminated during early embryogenesis. Autophagy is involved in the elimination of sperm mitochondria and mtDNA in early embryos in Caenorhabditis elegans; however, solid ev...

journal_title：Autophagy

authors： Luo SM,Sun QY

更新日期：2013-12-01 00:00:00

abstract：:The Atg1/ULK1 complex plays a central role in starvation-induced autophagy, integrating signals from upstream sensors such as MTOR and AMPK and transducing them to the downstream autophagy pathway. Much progress has been made in the last few years in understanding the mechanisms by which the complex is regulated throu...

journal_title：Autophagy

authors： Wong PM,Puente C,Ganley IG,Jiang X

更新日期：2013-02-01 00:00:00