Autophagy is not involved in the degradation of sperm mitochondria after fertilization in mice.

abstract：:We have reported in a variety of mammalian cells the reversible formation of a filamentous actin (F-actin)-enriched aggresome generated by the actin toxin jasplakinolide (Lázaro-Diéguez et al., J Cell Sci 2008; 121:1415-25). Notably, this F-actin aggresome (FAG) resembles in many aspects the pathological Hirano body, ...

journal_title：Autophagy

authors： Lázaro-Diéguez F,Knecht E,Egea G

更新日期：2008-07-01 00:00:00

abstract：:Heme is an essential molecule expressed in many tissues where it plays key roles as the prosthetic group of several proteins involved in vital physiological and metabolic processes such as gas and electron transport. Structurally, heme is a tetrapyrrole ring containing an atom of iron (Fe) in its center. When released...

journal_title：Autophagy

authors： Travassos LH,Vasconcellos LR,Bozza MT,Carneiro LA

更新日期：2017-03-04 00:00:00

abstract：:Antagonizing the strongly activated pathway of autophagy in renal ischemic injury has been associated with poor outcome. In our recent study we used mice with a selective deletion of Atg5 in the S3 proximal tubule segment, which is most susceptible to ischemic damage. In line with the notion that autophagy is a prosur...

journal_title：Autophagy

authors： Melk A,Baisantry A,Schmitt R

更新日期：2016-01-01 00:00:00

abstract：:Autophagy is a complex, multi-step and biologically important pathway mediated by autophagosomes and autolysosomes. Accurately dissecting and detecting different stages of autophagy is important to elucidate its molecular mechanism and thereby facilitate the discovery of pharmaceutical molecules. We herein reported a ...

journal_title：Autophagy

authors： Chen JJ,Jing J,Chang H,Rong Y,Hai Y,Tang J,Zhang JL,Xu P

更新日期：2013-06-01 00:00:00

abstract：:Efavirenz (EFV) is the most widely used non-nucleoside reverse transcriptase inhibitor applied in highly active antiretroviral therapy (HAART), the combined pharmacological treatment of the human immunodeficiency virus infection. Its use has been associated with the development of several adverse events including hepa...

journal_title：Autophagy

authors： Apostolova N,Gomez-Sucerquia LJ,Gortat A,Blas-Garcia A,Esplugues JV

更新日期：2011-11-01 00:00:00

abstract：:In humans, loss of TBC1D20 (TBC1 domain family, member 20) protein function causes Warburg Micro syndrome 4 (WARBM4), an autosomal recessive disorder characterized by congenital eye, brain, and genital abnormalities. TBC1D20-deficient mice exhibit ocular abnormalities and male infertility. TBC1D20 is a ubiquitously ex...

journal_title：Autophagy

authors： Sidjanin DJ,Park AK,Ronchetti A,Martins J,Jackson WT

更新日期：2016-10-02 00:00:00

abstract：:Protein misfolding is the common theme for neurodegenerative disorders including Huntington disease (HD), which is mainly caused by cytotoxicity of the mutant HTT (huntingtin) protein (mHTT). The soluble mHTT has an expanded polyglutamine (polyQ) stretch that may adopt multiple conformations, among which the one recog...

journal_title：Autophagy

authors： Sun X,Fu Y,Pan Y,Lu B

更新日期：2017-01-01 00:00:00

abstract：:Phagocytosis plays a central role in immunity and tissue homeostasis. After internalization of cargo into single-membrane phagosomes, these compartments undergo a maturation sequences that terminates in lysosome fusion and cargo degradation. Components of the autophagy pathway have recently been linked to phagosome ma...

journal_title：Autophagy

authors： Cemma M,Grinstein S,Brumell JH

更新日期：2016-09-01 00:00:00

abstract：:Proteome profiling and global protein-interaction approaches have significantly improved our knowledge of the protein interactomes of autophagy and other cellular stress-response pathways. New discoveries regarding protein complexes, interaction partners, interaction domains, and biological roles of players that are p...

journal_title：Autophagy

authors： Ho CJ,Samarasekera G,Rothe K,Xu J,Yang KC,Leung E,Chan M,Jiang X,Gorski SM

更新日期：2020-06-07 00:00:00

abstract：:Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine the maximum tolerated dose (MTD) and efficacy of HCQ in combination with radiation therapy (RT) and temozolomide (TMZ) for newly diagnos...

journal_title：Autophagy

authors： Rosenfeld MR,Ye X,Supko JG,Desideri S,Grossman SA,Brem S,Mikkelson T,Wang D,Chang YC,Hu J,McAfee Q,Fisher J,Troxel AB,Piao S,Heitjan DF,Tan KS,Pontiggia L,O'Dwyer PJ,Davis LE,Amaravadi RK

更新日期：2014-08-01 00:00:00

abstract：:Chronic drinking leads to myocardial contractile dysfunction where ethanol metabolism plays an essential role. Acetaldehyde, the main ethanol metabolite, mediates alcohol-induced cell injury although the underlying mechanism is still elusive. This study was designed to examine the mechanism involved in accelerated eth...

journal_title：Autophagy

authors： Guo R,Hu N,Kandadi MR,Ren J

更新日期：2012-04-01 00:00:00

abstract：:Macroautophagy/autophagy is critical in maintaining cellular functions and homeostasis. Dynamic regulation of autophagy is associated with development of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH); however, the mechanisms involved in the regulation of autophagy in NAFLD/NASH are n...

journal_title：Autophagy

authors： Wu X,Nagy LE

更新日期：2020-07-01 00:00:00

abstract：:A coding polymorphism of the critical autophagic effector ATG16L1 (T300A) increases the risk of Crohn disease, but how this mutation influences the function of ATG16L1 has remained unclear. In a recent report, we showed that the A300 allele alters the ability of the C-terminal WD40 domain of ATG16L1 to interact with p...

journal_title：Autophagy

authors： Serramito-Gómez I,Boada-Romero E,Pimentel-Muiños FX

更新日期：2016-11-01 00:00:00

abstract：:The acetylase inhibitor, spermidine and the deacetylase activator, resveratrol, both induce autophagy and prolong life span of the model organism Caenorhabditis elegans in an autophagydependent fashion. Based on these premises, we investigated the differences and similarities in spermidine and resveratrol-induced auto...

journal_title：Autophagy

authors： Mariño G,Morselli E,Bennetzen MV,Eisenberg T,Megalou E,Schroeder S,Cabrera S,Bénit P,Rustin P,Criollo A,Kepp O,Galluzzi L,Shen S,Malik SA,Maiuri MC,Horio Y,López-Otín C,Andersen JS,Tavernarakis N,Madeo F,Kroemer G

更新日期：2011-06-01 00:00:00

abstract：:Oxidative stress-induced granulosa cell (GCs) death represents a common reason for follicular atresia. Follicle-stimulating hormone (FSH) has been shown to prevent GCs from oxidative injury, although the underlying mechanism remains to be elucidated. Here we first report that the suppression of autophagic cell death v...

journal_title：Autophagy

authors： Shen M,Jiang Y,Guan Z,Cao Y,Li L,Liu H,Sun SC

更新日期：2017-08-03 00:00:00

abstract：:FTY720, a sphingosine analog, is a novel immunosuppressant currently undergoing multiple clinical trials for the prevention of organ transplant rejection and treatment of various autoimmune diseases. Recent studies indicate an additional cytotoxic effect of FTY720 and its preclinical efficacy in a variety of cancer mo...

journal_title：Autophagy

authors： Zhang N,Qi Y,Wadham C,Wang L,Warren A,Di W,Xia P

更新日期：2010-11-01 00:00:00

abstract：:As a highly dynamic organelle, mitochondria undergo constitutive fusion and fission as well as biogenesis and degradation. Mitophagy, selective mitochondrial degradation through autophagy, is a conserved cellular process used for the elimination of excessive and damaged mitochondria in eukaryotes. Despite the signific...

journal_title：Autophagy

authors： Mao K,Klionsky DJ

更新日期：2013-11-01 00:00:00

abstract：:Cytotoxic necrotizing factor 1 is a bacterial protein toxin from Escherichia coli that is able to activate the Rho GTPases and to hinder apoptosis and mitotic catastrophe. Upon exposure to toxin, cells undergo a complex framework of changes, including cytoskeleton remodeling and multinucleation. These cells also show ...

journal_title：Autophagy

authors： Fiorentini C,Malorni W

更新日期：2006-10-01 00:00:00

abstract：:Overcoming metabolic stress is a critical step in tumorigenesis. Acetyl coenzyme A (acetyl-CoA) converted from glucose or acetate is a substrate used for histone acetylation to regulate gene expression. However, how acetyl-CoA is produced under nutritional stress conditions is unclear. Herein we report that nutritiona...

journal_title：Autophagy

authors： Li X,Qian X,Lu Z

更新日期：2017-10-03 00:00:00

abstract：:Innate immune defense against intracellular pathogens, like Salmonella, relies heavily on the autophagy machinery of the host. This response is studied intensively in epithelial cells, the target of Salmonella during gastrointestinal infections. However, little is known of the role that autophagy plays in macrophages,...

journal_title：Autophagy

authors： Masud S,Prajsnar TK,Torraca V,Lamers GEM,Benning M,Van Der Vaart M,Meijer AH

更新日期：2019-05-01 00:00:00

abstract：:Bulk degradation and nutrient recycling are events associated with autophagy. The core components of the autophagy machinery have been elucidated recently using molecular and genetic approaches. In particular, two ubiquitin-like proteins, ATG8 and ATG12, which conjugate with phosphatidylethanolamine (PE) and ATG5, res...

journal_title：Autophagy

authors： Xiao S,Chye ML

更新日期：2010-08-01 00:00:00

abstract：:Increasing evidence suggests that misfolded proteins and intracellular aggregates contribute to cardiac disease and heart failure. We wished to determine if autophagic induction by Atg7 is sufficient to reduce misfolded protein and aggregate content in protein misfolding-stressed cardiomyocytes. We used loss- and gain...

journal_title：Autophagy

authors： Pattison JS,Robbins J

更新日期：2011-10-01 00:00:00

abstract：:Atg18p and Atg21p are two highly homologous yeast autophagy proteins. Atg18p functions in both autophagy and the selective Cvt-pathway, while the function of Atg21p is restricted to the Cvt-pathway. The yeast genome encodes with Ygr223cp (Hsv2p), a third member of this protein family. So far no function has been assig...

journal_title：Autophagy

authors： Krick R,Henke S,Tolstrup J,Thumm M

更新日期：2008-10-01 00:00:00

abstract：:In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea cycle and CPS1 are only present in the liver and, to a minor extent, in the kidney. To address the possibility that SIRT5 is involved i...

journal_title：Autophagy

authors： Polletta L,Vernucci E,Carnevale I,Arcangeli T,Rotili D,Palmerio S,Steegborn C,Nowak T,Schutkowski M,Pellegrini L,Sansone L,Villanova L,Runci A,Pucci B,Morgante E,Fini M,Mai A,Russo MA,Tafani M

更新日期：2015-01-01 00:00:00

abstract：:Macroautophagy is a major lysosomal degradation pathway for cellular components in eukaryotic cells. Baseline macroautophagy is important for quality control of the cytoplasm in order to avoid the accumulation of cytotoxic products. Its stimulation by various stressful situations, including nutrient starvation, is imp...

journal_title：Autophagy

authors： Tuloup-Minguez V,Greffard A,Codogno P,Botti J

更新日期：2011-01-01 00:00:00

abstract：:Mesenchymal stem cell (MSC) transplantation has been widely applied as a potential therapeutic for multiple diseases. However, the underlying therapeutic mechanisms are not fully understood, especially the paradox between the low survival rate of transplanted cells and the beneficial therapeutic effects generated by t...

journal_title：Autophagy

authors： Liu H,Liu S,Qiu X,Yang X,Bao L,Pu F,Liu X,Li C,Xuan K,Zhou J,Deng Z,Liu S,Jin Y

更新日期：2020-12-01 00:00:00

abstract：:The critical role of the cellular autophagy pathway in viral infection and pathogenesis has become increasingly apparent. Mounting evidences suggest that viruses have developed different strategies to meticulously modulate intracellular autophagy for their own benefits, thereby either promoting efficient viral replica...

journal_title：Autophagy

authors： Liang C,E X,Jung JU

更新日期：2008-04-01 00:00:00

abstract：:Autophagic cell death has been observed in granulosa cell cultures via the oxLDL-dependent activation of lectin-like oxidized low density lipoprotein receptor 1 (LOX-1). This activation might differ for cytokeratin-positive (CK(+)) and CK(-) granulosa cells. In particular, LOX-1 and toll-like receptor 4 (TLR4), one of...

journal_title：Autophagy

authors： Serke H,Vilser C,Nowicki M,Hmeidan FA,Blumenauer V,Hummitzsch K,Lösche A,Spanel-Borowski K

更新日期：2009-10-01 00:00:00

abstract：:Although alterations of the macroautophagy/autophagy-lysosome pathway have been observed in cancer for many years, the mechanisms underlying these changes and the importance of autophagic and lysosomal reprogramming by cancer have yet to be well identified. Our recent study demonstrates that oncogenic BRAF signaling p...

journal_title：Autophagy

authors： Li S,Song Y,Quach C,Nemecio D,Liang C

更新日期：2019-10-01 00:00:00

abstract：:There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria via a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We thus ...

journal_title：Autophagy

authors： Wu H,Wang Y,Li W,Chen H,Du L,Liu D,Wang X,Xu T,Liu L,Chen Q

更新日期：2019-11-01 00:00:00