Abstract:
:Lafora disease (LD) is an inherited and fatal form of neurodegenerative disorder characterized by the presence of an abnormal form of glycogen inclusions, called Lafora bodies, in neurons and other tissues. While Lafora bodies have been thought to underlie the neuropathology in LD, the specific process by which these inclusions might affect the neuronal functions was not very well understood. Here we review one of our recent studies on the LD animal model, wherein we have shown that the Lafora bodies might contribute to the impairment in the endosomal-lysosomal and autophagy pathways.
journal_name
Autophagyjournal_title
Autophagyauthors
Puri R,Ganesh Sdoi
10.4161/auto.8.2.19010subject
Has Abstractpub_date
2012-02-01 00:00:00pages
289-90issue
2eissn
1554-8627issn
1554-8635pii
19010journal_volume
8pub_type
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