The actin cytoskeleton participates in the early events of autophagosome formation upon starvation induced autophagy.

abstract：:Retinal ischemia is a major cause of vision loss and a common underlying mechanism associated with diseases, such as diabetic retinopathy and central retinal artery occlusion. We have previously demonstrated the robust neuroprotection in retina induced by post-conditioning (post-C), a brief period of ischemia, 24 h, f...

journal_title：Autophagy

authors： Mathew B,Chennakesavalu M,Sharma M,Torres LA,Stelman CR,Tran S,Patel R,Burg N,Salkovski M,Kadzielawa K,Seiler F,Aldrich LN,Roth S

更新日期：2020-05-26 00:00:00

abstract：:Autophagy is a fundamental process for anti-viral defense. Not surprisingly, viruses have developed strategies to subvert or use autophagy for their own benefit. In cell culture, autophagy proteins are proviral factors that favor initiation of hepatitis C virus (HCV) infection. Autophagy proteins are required for tran...

journal_title：Autophagy

authors： Dreux M,Chisari FV

更新日期：2009-11-01 00:00:00

abstract：:Ubiquitin-proteasome system and autophagy are the two major mechanisms for protein degradation in eukaryotic cells. LC3, a ubiquitin-like protein, plays an essential role in autophagy through its ability to be conjugated to phosphatidylethanolamine. In this study, we discovered a novel LC3-processing activity, and bio...

journal_title：Autophagy

authors： Gao Z,Gammoh N,Wong PM,Erdjument-Bromage H,Tempst P,Jiang X

更新日期：2010-01-01 00:00:00

abstract：:The lysosome is a key subcellular organelle that receives and degrades macromolecules from endocytic, secretory and autophagic pathways. Lysosomal function is thus critical for an efficient autophagic process. However, the molecular mechanisms mediating lysosomal function upon autophagic induction are largely unknown....

journal_title：Autophagy

authors： Zhou J,Tan SH,Codogno P,Shen HM

更新日期：2013-05-01 00:00:00

abstract：:We have previously shown that Kaposi sarcoma-associated herpesvirus (KSHV) impairs monocyte differentiation into dendritic cells (DCs). Macroautophagy/autophagy has been reported to be essential in such a differentiating process. Here we extended these studies and found that the impairment of DC formation by KSHV occu...

journal_title：Autophagy

authors： Santarelli R,Granato M,Pentassuglia G,Lacconi V,Gilardini Montani MS,Gonnella R,Tafani M,Torrisi MR,Faggioni A,Cirone M

更新日期：2016-12-01 00:00:00

abstract：:Nutrients not only act as building blocks but also as signaling molecules. Nutrient-availability promotes cell growth and proliferation and suppresses catabolic processes, such as macroautophagy/autophagy. These effects are mediated by checkpoint kinases such as MTOR (mechanistic target of rapamycin kinase), which is ...

journal_title：Autophagy

authors： Sanchez-Garrido J,Shenoy AR

更新日期：2020-07-05 00:00:00

abstract：:Rapamycin is an inhibitor of mTOR, a key component of the mTORC1 complex that controls the growth and survival of cells in response to growth factors, nutrients, energy balance and stresses. The downstream targets of mTORC1 include ribosome biogenesis, transcription, translation and macroautophagy. Recently it was pro...

journal_title：Autophagy

authors： Wyttenbach A,Hands S,King MA,Lipkow K,Tolkovsky AM

更新日期：2008-05-01 00:00:00

abstract：:Adaptive immunity, which plays an important role in the development of atherosclerosis, is mediated by major histocompatibility complex (MHC)-dependent antigen presentation. In atherosclerotic lesions, macrophages constitute an important class of antigen-presenting cells that activate adaptive immune responses to oxid...

journal_title：Autophagy

authors： Choi SH,Gonen A,Diehl CJ,Kim J,Almazan F,Witztum JL,Miller YI

更新日期：2015-01-01 00:00:00

abstract：:A coding polymorphism of the critical autophagic effector ATG16L1 (T300A) increases the risk of Crohn disease, but how this mutation influences the function of ATG16L1 has remained unclear. In a recent report, we showed that the A300 allele alters the ability of the C-terminal WD40 domain of ATG16L1 to interact with p...

journal_title：Autophagy

authors： Serramito-Gómez I,Boada-Romero E,Pimentel-Muiños FX

更新日期：2016-11-01 00:00:00

abstract：:Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine the maximum tolerated dose (MTD) and efficacy of HCQ in combination with radiation therapy (RT) and temozolomide (TMZ) for newly diagnos...

journal_title：Autophagy

authors： Rosenfeld MR,Ye X,Supko JG,Desideri S,Grossman SA,Brem S,Mikkelson T,Wang D,Chang YC,Hu J,McAfee Q,Fisher J,Troxel AB,Piao S,Heitjan DF,Tan KS,Pontiggia L,O'Dwyer PJ,Davis LE,Amaravadi RK

更新日期：2014-08-01 00:00:00

abstract：:In 2013, Dr. Lora Hooper and colleagues described the induction of antibacterial macroautophagy/autophagy in intestinal epithelial cells as a cytoprotective host defense mechanism against invading Salmonella enterica serovar Typhimurium (S. Typhimurium). Canonical autophagy functions in a primarily degradative capacit...

journal_title：Autophagy

authors： Delorme-Axford E,Klionsky DJ

更新日期：2018-01-01 00:00:00

abstract：:The role of autophagy in the degradation of aggregate-prone proteins has been well established. As a result, autophagy upregulation has become an attractive therapeutic strategy for the treatment of proteinopathies, a group of diseases caused by the accumulation of mutant misfolded proteins. We have previously shown t...

journal_title：Autophagy

authors： Menzies FM,Rubinsztein DC

更新日期：2010-02-01 00:00:00

abstract：:Chronic drinking leads to myocardial contractile dysfunction where ethanol metabolism plays an essential role. Acetaldehyde, the main ethanol metabolite, mediates alcohol-induced cell injury although the underlying mechanism is still elusive. This study was designed to examine the mechanism involved in accelerated eth...

journal_title：Autophagy

authors： Guo R,Hu N,Kandadi MR,Ren J

更新日期：2012-04-01 00:00:00

abstract：:Antagonizing the strongly activated pathway of autophagy in renal ischemic injury has been associated with poor outcome. In our recent study we used mice with a selective deletion of Atg5 in the S3 proximal tubule segment, which is most susceptible to ischemic damage. In line with the notion that autophagy is a prosur...

journal_title：Autophagy

authors： Melk A,Baisantry A,Schmitt R

更新日期：2016-01-01 00:00:00

abstract：:To study mitochondrial protein age dynamics, we targeted a time-sensitive fluorescent protein, MitoTimer, to the mitochondrial matrix. Mitochondrial age was revealed by the integrated portions of young (green) and old (red) MitoTimer protein. Mitochondrial protein age was dependent on turnover rates as pulsed synthesi...

journal_title：Autophagy

authors： Ferree AW,Trudeau K,Zik E,Benador IY,Twig G,Gottlieb RA,Shirihai OS

更新日期：2013-11-01 00:00:00

abstract：:Degradation of intracellular components via macroautophagy is a complex multistep process that starts with the sequestration of cytosolic cargo in a de novo formed double-membrane vesicle or autophagosome. This compartment acquires the hydrolases required for cargo digestion by fusion with lysosomes. In contrast to th...

journal_title：Autophagy

authors： Koga H,Kaushik S,Cuervo AM

更新日期：2010-08-01 00:00:00

abstract：:Intervertebral disc degeneration (IDD) is the primary pathological mechanism that underlies low back pain. Overloading-induced cell death, especially endogenous stem cell death, is the leading factor that undermines intrinsic repair and aggravates IDD. Previous research has separately studied the effect of oxygen conc...

journal_title：Autophagy

authors： He R,Wang Z,Cui M,Liu S,Wu W,Chen M,Wu Y,Qu Y,Lin H,Chen S,Wang B,Shao Z

更新日期：2021-01-18 00:00:00

abstract：:Peroxisome proliferator-activated receptor-gamma (PPARgamma) is a major modulator of cellular lipid metabolism and organelle differentiation. To understand whether autophagy is involved in the processes of dysregulated fatty acid oxidation and induced oxidative stress accompanying prostatic carcinogenesis, we characte...

journal_title：Autophagy

authors： Jiang M,Jerome WG,Hayward SW

更新日期：2010-01-01 00:00:00

abstract：:Here, we present a summary of our recent findings on the (patho-)physiological relevance of PINK1-phosphorylated ubiquitin (p-S65-Ub). Using novel polyclonal antibodies, we find that p-S65-Ub specifically accumulates on damaged mitochondria. Phosphorylation of ubiquitin on serine 65 depends on the activity of PINK1 an...

journal_title：Autophagy

authors： Fiesel FC,Springer W

更新日期：2015-11-02 00:00:00

abstract：:The NIH-funded center for autophagy research named Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence, located at the University of New Mexico Health Science Center is now completing its second year as a working center with a mission to promote autophagy research locally, nationally...

journal_title：Autophagy

authors： Deretic V,Prossnitz E,Burge M,Campen MJ,Cannon J,Liu KJ,Liu M,Hall P,Sklar LA,Allers L,Mariscal L,Garcia SA,Weaver J,Baehrecke EH,Behrends C,Cecconi F,Codogno P,Chen GC,Elazar Z,Eskelinen EL,Fourie B,Gozuacik D

更新日期：2019-10-01 00:00:00

abstract：:Macroautophagy ("autophagy") is regulated by the same insulin-amino acid-mTOR signaling pathway that controls protein synthesis. Although the literature does not so far include any direct studies confirming this, we expect autophagy to increase during insulin resistance. We discuss the possibility that this may be a u...

journal_title：Autophagy

authors： Meijer AJ,Codogno P

更新日期：2007-09-01 00:00:00

abstract：:The Syrian hamster Harderian gland (HG) is a juxtaorbital organ exhibiting marked gender-associated morphological differences. Regarding contents of porphyrins, this gland is a good model for studying physiological oxidative stress effects, since both sexes present strong (in females) and moderate (in males) levels of...

journal_title：Autophagy

authors： Coto-Montes A,Tomás-Zapico C

更新日期：2006-04-01 00:00:00

abstract：:Macroautophagy sequesters superflous cytosol and organelles into double-membraned autophagosomes. Over 30 autophagy-related (ATG) genes have been identified without elucidating the molecular details of autophagosome biogenesis. All proposed models for autophagosome formation require membrane fusion events (Fig. 1). Pr...

journal_title：Autophagy

authors： Krick R,Bremer S,Welter E,Eskelinen EL,Thumm M

更新日期：2011-02-01 00:00:00

abstract：:The understanding of the membrane flow process during autophagosome formation is essential to illuminate the role of autophagy under various disease-causing conditions. Atg9 is the only identified integral membrane protein required for autophagosome formation, and it is thought to cycle between the membrane sources an...

journal_title：Autophagy

authors： He C,Baba M,Klionsky DJ

更新日期：2009-04-01 00:00:00

abstract：:Phagocytosis plays a central role in immunity and tissue homeostasis. After internalization of cargo into single-membrane phagosomes, these compartments undergo a maturation sequences that terminates in lysosome fusion and cargo degradation. Components of the autophagy pathway have recently been linked to phagosome ma...

journal_title：Autophagy

authors： Cemma M,Grinstein S,Brumell JH

更新日期：2016-09-01 00:00:00

abstract：:Genetic inactivation of PTEN through either gene deletion or mutation is common in metastatic prostate cancer, leading to activation of the phosphoinositide 3-kinase (PI3K-AKT) pathway, which is associated with poor clinical outcomes. The PI3K-AKT pathway plays a central role in various cellular processes supporting c...

journal_title：Autophagy

authors： Lamoureux F,Zoubeidi A

更新日期：2013-07-01 00:00:00

abstract：:Autophagy is one of the survival processes of cancer cells, especially in stressful conditions such as starvation, hypoxia and chemotherapeutic agents. However, its roles in tumor survival have not yet been fully elucidated. Here, we found for the first time that JAK2/STAT3 was activated in HeLa cells when they were s...

journal_title：Autophagy

authors： Yoon S,Woo SU,Kang JH,Kim K,Kwon MH,Park S,Shin HJ,Gwak HS,Chwae YJ

更新日期：2010-11-01 00:00:00

abstract：:Although Beclin 1 and mTOR are considered to be the main molecules to modulate the autophagic process, searching for other autophagy-regulating molecules is still an ongoing challenge to scientists. Here we demonstrated that FoxO1, a forkhead O family protein, is a mediator of autophagy. Upon oxidative stress or serum...

journal_title：Autophagy

authors： Zhao Y,Wang L,Yang J,Zhang P,Ma K,Zhou J,Liao W,Zhu WG

更新日期：2010-10-01 00:00:00

abstract：:The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) and the enzyme that produces it, SPHK1 (sphingosine kinase 1), regulate many processes important for the etiology of cancer. It has been suggested that SPHK1 levels are regulated by the tumor suppressor protein TP53, a key regulator of cell cycle arre...

journal_title：Autophagy

authors： Lima S,Takabe K,Newton J,Saurabh K,Young MM,Leopoldino AM,Hait NC,Roberts JL,Wang HG,Dent P,Milstien S,Booth L,Spiegel S

更新日期：2018-01-01 00:00:00

abstract：:ULK1 (unc-51 like autophagy activating kinase 1), the key mediator of MTORC1 signaling to autophagy, regulates early stages of autophagosome formation in response to starvation or MTORC1 inhibition. How ULK1 regulates the autophagy induction process remains elusive. Here, we identify that ATG13, a binding partner of U...

journal_title：Autophagy

authors： Park JM,Jung CH,Seo M,Otto NM,Grunwald D,Kim KH,Moriarity B,Kim YM,Starker C,Nho RS,Voytas D,Kim DH

更新日期：2016-01-01 00:00:00