Autophagy delays apoptosis in renal tubular epithelial cells in cisplatin cytotoxicity.

abstract：:In the fungal pathogen Fusarium oxysporum, vegetative hyphal fusion triggers nuclear mitotic division in the invading hypha followed by migration of a nucleus into the receptor hypha and degradation of the resident nucleus. Here we examined the role of autophagy in fusion-induced nuclear degradation. A search of the F...

journal_title：Autophagy

authors： Corral-Ramos C,Roca MG,Di Pietro A,Roncero MI,Ruiz-Roldán C

更新日期：2015-01-01 00:00:00

abstract：:The molecular mechanism of macroautophagy/autophagy induction has been intensively studied, but little is known about downregulation of autophagy and how this process is restricted. In particular, how is autophagy maintained at an appropriate homeostatic level when cells are subjected to prolonged stress? In this stud...

journal_title：Autophagy

authors： Feng Y,Klionsky DJ

更新日期：2016-07-02 00:00:00

abstract：:Hepatic stellate cell (HSC) activation, the transition from a resident quiescent HSC to a myofibroblastic collagen-producing HSC, is a fundamental feature of liver fibrosis. Autophagy has been implicated in major liver pathologies, such as HCV infection and hepatocarcinoma. However, its role in HSC biology is largely ...

journal_title：Autophagy

authors： Thoen LF,Guimarães EL,Grunsven LA

更新日期：2012-01-01 00:00:00

abstract：:Autophagy is a conserved membrane trafficking pathway that mediates the delivery of cytoplasmic substrates to the lysosome for degradation. Impaired autophagic function is implicated in the pathology of various neurodegenerative diseases. We have generated transgenic C. elegans that express human beta-amyloid peptide ...

journal_title：Autophagy

authors： Florez-McClure ML,Hohsfield LA,Fonte G,Bealor MT,Link CD

更新日期：2007-11-01 00:00:00

abstract：:Macroautophagy is an intracellular catabolic process involved in the formation of multiple membrane structures ranging from phagophores to autophagosomes and autolysosomes. Dysfunction of macroautophagy is implicated in both physiological and pathological conditions. To date, 38 autophagy-related (ATG) genes have been...

journal_title：Autophagy

authors： Xie Y,Kang R,Sun X,Zhong M,Huang J,Klionsky DJ,Tang D

更新日期：2015-01-01 00:00:00

abstract：:Autophagy, a catabolic pathway of lysosomal degradation, acts not only as an efficient recycle and survival mechanism during cellular stress, but also as an anti-infective machinery. The human pathogen Staphylococcus aureus (S. aureus) was originally considered solely as an extracellular bacterium, but is now recogniz...

journal_title：Autophagy

authors： Neumann Y,Bruns SA,Rohde M,Prajsnar TK,Foster SJ,Schmitz I

更新日期：2016-11-01 00:00:00

abstract：:DBI/ACBP (diazepam binding protein, acyl-CoA binding protein) participates in the regulation of fatty acid metabolism when it is localized within cells, whereas outside of cells it acts as a diazepam-binding protein. Recent results indicate that many different mammalian cell types release DBI/ACBP upon in vitro or in ...

journal_title：Autophagy

authors： Bravo-San Pedro JM,Sica V,Martins I,Anagnostopoulos G,Maiuri C,Kroemer G

更新日期：2019-11-01 00:00:00

abstract：:Microtubule-associated protein light chain 3 (LC3) is now widely used to monitor autophagy. One approach is to detect LC3 conversion (LC3-I to LC3-II) by immunoblot analysis because the amount of LC3-II is clearly correlated with the number of autophagosomes. However, LC3-II itself is degraded by autophagy, making int...

journal_title：Autophagy

authors： Mizushima N,Yoshimori T

更新日期：2007-11-01 00:00:00

abstract：:Loss-of-function mutations in PARK2/PARKIN and PINK1 cause early-onset autosomal recessive Parkinson disease (PD). The cytosolic E3 ubiquitin-protein ligase PARK2 cooperates with the mitochondrial kinase PINK1 to maintain mitochondrial quality. A loss of mitochondrial transmembrane potential (ΔΨ) leads to the PINK1-de...

journal_title：Autophagy

authors： Bertolin G,Ferrando-Miguel R,Jacoupy M,Traver S,Grenier K,Greene AW,Dauphin A,Waharte F,Bayot A,Salamero J,Lombès A,Bulteau AL,Fon EA,Brice A,Corti O

更新日期：2013-11-01 00:00:00

abstract：:The link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-rich repeat kinase 2 (LR...

journal_title：Autophagy

authors： Bravo-San Pedro JM,Gómez-Sánchez R,Niso-Santano M,Pizarro-Estrella E,Aiastui-Pujana A,Gorostidi A,Climent V,López de Maturana R,Sanchez-Pernaute R,López de Munain A,Fuentes JM,González-Polo RA

更新日期：2012-10-01 00:00:00

abstract：:SNCA/α-synuclein aggregation plays a crucial role in synucleinopathies such as Parkinson disease and dementia with Lewy bodies. Aggregating and nonaggregating SNCA species are degraded by the autophagy-lysosomal pathway (ALP). Previously, we have shown that the ALP is not only responsible for SNCA degradation but is a...

journal_title：Autophagy

authors： Poehler AM,Xiang W,Spitzer P,May VE,Meixner H,Rockenstein E,Chutna O,Outeiro TF,Winkler J,Masliah E,Klucken J

更新日期：2014-01-01 00:00:00

abstract：:Macroautophagy/autophagy dysfunction is associated with many neurodegenerative diseases. TFEB (transcription factor EB), an important molecule that regulates lysosomal and autophagy function, is regarded as a potential target for treating some neurodegenerative diseases. However, the relationship between autophagy dys...

journal_title：Autophagy

authors： Ye B,Wang Q,Hu H,Shen Y,Fan C,Chen P,Ma Y,Wu H,Xiang M

更新日期：2019-06-01 00:00:00

abstract：:Upon completion of cytokinesis, the midbody ring is transported asymmetrically into one of the two daughter cells where it becomes a midbody ring derivative that is degraded by autophagy. In this study we showed that the ubiquitin-binding autophagy receptor SQSTM1/p62 and the interacting adaptor protein WDFY3/ALFY for...

journal_title：Autophagy

authors： Isakson P,Lystad AH,Breen K,Koster G,Stenmark H,Simonsen A

更新日期：2013-12-01 00:00:00

abstract：:SPHK1 (sphingosine kinase 1), a regulator of sphingolipid metabolites, plays a causal role in the development of hepatocellular carcinoma (HCC) through augmenting HCC invasion and metastasis. However, the mechanism by which SPHK1 signaling promotes invasion and metastasis in HCC remains to be clarified. Here, we repor...

journal_title：Autophagy

authors： Liu H,Ma Y,He HW,Zhao WL,Shao RG

更新日期：2017-05-04 00:00:00

abstract：:Cocaine abuse leads to neuroinflammation, which, in turn, contributes to the pathogenesis of neurodegeneration associated with advanced HIV-1 infection. Autophagy plays important roles in both innate and adaptive immune responses. However, the possible functional link between cocaine and autophagy has not been explore...

journal_title：Autophagy

authors： Guo ML,Liao K,Periyasamy P,Yang L,Cai Y,Callen SE,Buch S

更新日期：2015-01-01 00:00:00

abstract：:Rapamycin is an inhibitor of mTOR, a key component of the mTORC1 complex that controls the growth and survival of cells in response to growth factors, nutrients, energy balance and stresses. The downstream targets of mTORC1 include ribosome biogenesis, transcription, translation and macroautophagy. Recently it was pro...

journal_title：Autophagy

authors： Wyttenbach A,Hands S,King MA,Lipkow K,Tolkovsky AM

更新日期：2008-05-01 00:00:00

abstract：:Thioglycolate-elicited macrophages exhibit abundant conjugation of LC3 with PE (LC3-II). Among other autophagy-related (ATG) proteins, it is proposed that, like in yeast, both ATG5 and ATG7 are essential for LC3 conjugation. Using atg5-deficient ( -/- ) and atg7-/- macroph...

journal_title：Autophagy

authors： Vujić N,Bradić I,Goeritzer M,Kuentzel KB,Rainer S,Kratky D,Radović B

更新日期：2021-01-18 00:00:00

abstract：:Preclinical studies indicate autophagy inhibition with hydroxychloroquine (HCQ) can augment the efficacy of DNA-damaging therapy. The primary objective of this trial was to determine the maximum tolerated dose (MTD) and efficacy of HCQ in combination with radiation therapy (RT) and temozolomide (TMZ) for newly diagnos...

journal_title：Autophagy

authors： Rosenfeld MR,Ye X,Supko JG,Desideri S,Grossman SA,Brem S,Mikkelson T,Wang D,Chang YC,Hu J,McAfee Q,Fisher J,Troxel AB,Piao S,Heitjan DF,Tan KS,Pontiggia L,O'Dwyer PJ,Davis LE,Amaravadi RK

更新日期：2014-08-01 00:00:00

abstract：:Breast cancer tissue contains a small population of cells that have the ability to self-renew; these cells are known as cancer stem-like cells (CSCs). We have recently shown that autophagy is essential for the tumorigenicity of these CSCs. Salinomycin (Sal), a K (+) /H (+) ionophore, has recently been shown to be at l...

journal_title：Autophagy

authors： Yue W,Hamaï A,Tonelli G,Bauvy C,Nicolas V,Tharinger H,Codogno P,Mehrpour M

更新日期：2013-05-01 00:00:00

abstract：:The incidence of pancreatic adenocarcinoma is increasing with more than 43,000 predicted new cases in the US and 65,000 in Europe this year. Pancreatic cancer patients have a short life expectancy with less than 3-4% 5-y survival, which results in an equivalent incidence and mortality rate. One of the major challenges...

journal_title：Autophagy

authors： Hamidi T,Cano CE,Grasso D,Garcia MN,Sandi MJ,Calvo EL,Dagorn JC,Lomberk G,Goruppi S,Urrutia R,Carracedo A,Velasco G,Iovanna JL

更新日期：2013-01-01 00:00:00

abstract：:Understanding of the mechanism for myeloid differentiation provides important insights into the hematopoietic developmental processes. By using an ESC-derived myeloid progenitor cell model, we found that CSF2/GM-CSF triggered macrophage differentiation and activation of the MTOR signaling pathway. Activation or inhibi...

journal_title：Autophagy

authors： Zhang M,Liu F,Zhou P,Wang Q,Xu C,Li Y,Bian L,Liu Y,Zhou J,Wang F,Yao Y,Fang Y,Li D

更新日期：2019-07-01 00:00:00

abstract：:Coxsackievirus B3 (CVB3) has previously been shown to utilize autophagy in an advantageous manner during the course of infection of the host cell. However, few studies have determined whether stem cells induce autophagy in a similar fashion, and whether virus-induced autophagy occurs following infection of stem cells....

journal_title：Autophagy

authors： Tabor-Godwin JM,Tsueng G,Sayen MR,Gottlieb RA,Feuer R

更新日期：2012-06-01 00:00:00

abstract：:Autophagy and microRNA (miRNA) are important regulators during cancer cell tumorigenesis. Impaired autophagy and high expression of the oncogenic microRNA MIR224 are prevalent in hepatocellular carcinoma (HCC); however, the relationship between the 2 phenomena remains elusive. In this study, we are the first to reveal...

journal_title：Autophagy

authors： Lan SH,Wu SY,Zuchini R,Lin XZ,Su IJ,Tsai TF,Lin YJ,Wu CT,Liu HS

更新日期：2014-09-01 00:00:00

abstract：:Autophagy is a fundamental process for anti-viral defense. Not surprisingly, viruses have developed strategies to subvert or use autophagy for their own benefit. In cell culture, autophagy proteins are proviral factors that favor initiation of hepatitis C virus (HCV) infection. Autophagy proteins are required for tran...

journal_title：Autophagy

authors： Dreux M,Chisari FV

更新日期：2009-11-01 00:00:00

abstract：:Accumulation of mutant TP53 proteins in cancer cells has been recognized as an important factor that promotes cancer progression and metastasis. Thus, strategies that promote the degradation of mutant TP53 might be beneficial for the treatment of cancers. In a recent issue of Genes & Development, we demonstrated that ...

journal_title：Autophagy

authors： Vakifahmetoglu-Norberg H,Yuan J

更新日期：2013-12-01 00:00:00

abstract：:Dysfunction of macroautophagy/autophagy has been postulated as a major cellular toxicological response to nanomaterials. It has been reported that excessive autophagy activation, induced by silica nanoparticles (SiNPs), contributes to autophagy dysfunction, whereas little is known how SiNPs trigger autophagy activatio...

journal_title：Autophagy

authors： Ruan C,Wang C,Gong X,Zhang Y,Deng W,Zhou J,Huang D,Wang Z,Zhang Q,Guo A,Lu J,Gao J,Peng D,Xue Y

更新日期：2020-05-23 00:00:00

abstract：:Atg13 is an essential subunit of the Atg1 autophagy initiation complex in yeast and its mammalian counterpart, ATG13, is indispensable for autophagy induction by the ULK1 complex. The N terminus of the protein folds into a HORMA domain, an architecture that has been revealed by crystallography. 1-4 In human cells, the...

journal_title：Autophagy

authors： Popelka H,Klionsky DJ

更新日期：2017-03-04 00:00:00

abstract：:Macroautophagy/autophagy involves the formation of an autophagosome, a double-membrane vesicle that delivers sequestered cytoplasmic cargo to lysosomes for degradation and recycling. Closely related, endocytosis mediates the sorting and transport of cargo throughout the cell, and both processes are important for cellu...

journal_title：Autophagy

authors： Palmisano NJ,Rosario N,Wysocki M,Hong M,Grant B,Meléndez A

更新日期：2017-10-03 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is among the most lethal and prevalent cancers in the human population. The initiation and progression of HCC is closely associated with chronic liver inflammation. Recent research indicates that nonhomologous end joining (NHEJ), one of the DNA repair mechanisms, autophagy and senescence...

journal_title：Autophagy

authors： Wang Z,Lin H,Hua F,Hu ZW

更新日期：2013-06-01 00:00:00

abstract：:Combining two different treatment modalities for targeting malignancies is gaining importance, with preclinical/clinical results indicating higher success rates in eradicating tumors or having longer remission periods. A better understanding of the synergy between the treatments helps in optimizing the dose and time o...

journal_title：Autophagy

authors： Ramakrishnan R,Gabrilovich DI

更新日期：2013-04-01 00:00:00