Abstract:
:Accumulation of mutant TP53 proteins in cancer cells has been recognized as an important factor that promotes cancer progression and metastasis. Thus, strategies that promote the degradation of mutant TP53 might be beneficial for the treatment of cancers. In a recent issue of Genes & Development, we demonstrated that blocking macroautophagy under nutritional stress condition leads to the degradation of mutant TP53 through activating the chaperone-mediated autophagy (CMA) pathway in nonproliferating cancer cells. We propose CMA as a new degradative mechanism for mutant TP53 and the possibility of activating CMA as a new treatment for cancers with mutant TP53.
journal_name
Autophagyjournal_title
Autophagyauthors
Vakifahmetoglu-Norberg H,Yuan Jdoi
10.4161/auto.26338subject
Has Abstractpub_date
2013-12-01 00:00:00pages
2158-60issue
12eissn
1554-8627issn
1554-8635pii
26338journal_volume
9pub_type
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