Abstract:
:Autophagy is a degradative process conserved among eukaryotic cells. It allows the elimination of cytoplasm including aberrant protein aggregates and damaged organelles. Accordingly, it is implicated in normal developmental processes and also serves a protective role in tumor suppression and elimination of invading pathogens, whereas defects in autophagy are associated with various human diseases including cancer and neurodegeneration. Atg proteins mediate the sequestration event that occurs at the preautophagosomal structure (PAS) by catalyzing the formation of double-membrane vesicles, termed autophagosomes. In Saccharomyces cerevisiae, the integral membrane protein Atg9 that is required for autophagy cycles through the PAS. Here, we demonstrate that Atg9 shuttles between this location and mitochondria. These data support a new model where mitochondria may provide at least part of the autophagosomal lipids and suggest a novel cellular function for this well-studied organelle.
journal_name
Autophagyjournal_title
Autophagyauthors
Reggiori F,Shintani T,Nair U,Klionsky DJdoi
10.4161/auto.1.2.1840subject
Has Abstractpub_date
2005-07-01 00:00:00pages
101-9issue
2eissn
1554-8627issn
1554-8635pii
1840journal_volume
1pub_type
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