Abstract:
:Autophagy is a degradative pathway conserved among eukaryotes. It is a major route for degradation of long-lived proteins and entire organelles, such as peroxisomes. Atg26, a sterol glucosyltransferase, is specifically required for micro- and macropexophagy, but not for starvation-induced bulk autophagy in Pichia pastoris. Here we study the requirement of Saccharomyces cerevisiae Atg26 in the Cvt pathway, nonspecific autophagy and pexophagy. Our results show that the S. cerevisiae atg26Delta strain is not defective in prApe1 maturation, macroautophagy or peroxisome degradation, in contrast to the situation seen in Pichia pastoris. These studies highlight the importance of examining mutants in multiple organisms.
journal_name
Autophagyjournal_title
Autophagyauthors
Cao Y,Klionsky DJdoi
10.4161/auto.3371subject
Has Abstractpub_date
2007-01-01 00:00:00pages
17-20issue
1eissn
1554-8627issn
1554-8635pii
3371journal_volume
3pub_type
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