Abstract:
:Combining two different treatment modalities for targeting malignancies is gaining importance, with preclinical/clinical results indicating higher success rates in eradicating tumors or having longer remission periods. A better understanding of the synergy between the treatments helps in optimizing the dose and time of administration. We found that chemotherapy enhanced the levels of insulin-like growth factor 2 receptor/cation-independent mannose-6-phosphate receptor (IGF2R) on the surface of tumor cells, which leads to better tumor targeting by cytotoxic T cells (CTLs). Early evidence indicates that upregulation of IGF2R involves the autophagy pathway.
journal_name
Autophagyjournal_title
Autophagyauthors
Ramakrishnan R,Gabrilovich DIdoi
10.4161/auto.23485subject
Has Abstractpub_date
2013-04-01 00:00:00pages
615-6issue
4eissn
1554-8627issn
1554-8635pii
23485journal_volume
9pub_type
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