Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy.

abstract：:In 2013, Dr. Lora Hooper and colleagues described the induction of antibacterial macroautophagy/autophagy in intestinal epithelial cells as a cytoprotective host defense mechanism against invading Salmonella enterica serovar Typhimurium (S. Typhimurium). Canonical autophagy functions in a primarily degradative capacit...

journal_title：Autophagy

authors： Delorme-Axford E,Klionsky DJ

更新日期：2018-01-01 00:00:00

abstract：:The extensive autophagic-lysosomal pathology in Alzheimer disease (AD) brain has revealed a major defect: in the proteolytic clearance of autophagy substrates. Autophagy failure contributes on several levels to AD pathogenesis and has become an important therapeutic target for AD and other neurodegenerative diseases. ...

journal_title：Autophagy

authors： Yang DS,Stavrides P,Mohan PS,Kaushik S,Kumar A,Ohno M,Schmidt SD,Wesson DW,Bandyopadhyay U,Jiang Y,Pawlik M,Peterhoff CM,Yang AJ,Wilson DA,St George-Hyslop P,Westaway D,Mathews PM,Levy E,Cuervo AM,Nixon RA

更新日期：2011-07-01 00:00:00

abstract：:Loss of the lysosomal chloride transport protein ClC-7 leads to complex phenotypes in mice and man, including osteopetrosis, accumulation of lysosomal storage material, and neurodegeneration. Using novel tissue-specific ClC-7 knockout mice, we have shown that upon loss of ClC-7, lysosomal degradation of endocytosed pr...

journal_title：Autophagy

authors： Wartosch L,Stauber T

更新日期：2010-01-01 00:00:00

abstract：:Minocycline has been shown to alleviate several neurological disorders. Unexpectedly, we found that minocycline had opposite effects on glioma cells: minocycline induced nonapoptotic cell death in glioma cells. The glioma cell death was associated with the presence of autophagic vacuoles in the cytoplasm. Minocycline ...

journal_title：Autophagy

authors： Liu WT,Lin CH,Hsiao M,Gean PW

更新日期：2011-02-01 00:00:00

abstract：:The class III phosphatidylinositol (PtdIns)-3 kinase, PIK3C3/VPS34, forms multiple complexes and regulates a variety of cellular functions, especially in intracellular vesicle trafficking and autophagy. Even though PtdIns3P, the product of PIK3C3, is thought to be a critical membrane marker for the autophagosome, it i...

journal_title：Autophagy

authors： Kim J,Guan KL

更新日期：2013-07-01 00:00:00

abstract：:Delivery of cellular contents to yeast vacuoles/mammalian lysosomes via autophagy ensures long-term cell survival and extends life span. When cultured yeast cells are grown for a prolonged period of time to enter stationary phase, a nondividing state mimicking quiescence, vacuolar membrane proteins partition into eith...

journal_title：Autophagy

authors： Wang CW

更新日期：2014-01-01 00:00:00

abstract：:In yeast and mammals, selective vacuolar delivery and degradation of whole mitochondria, or mitophagy, represents an important quality control system and is achieved by a cargo recognition mechanism enabling selective elimination of dysfunctional mitochondria. As photosynthetic organelles that need light for energy pr...

journal_title：Autophagy

authors： Izumi M,Nakamura S

更新日期：2017-07-03 00:00:00

abstract：:Autophagy research continues to expand exponentially. Clearly autophagy and metabolism are intimately connected; however, the rapid expansion of research into this topic inevitably brings the risk that important basic knowledge of metabolism will be overlooked when considering experimental data. Unfortunately, unaware...

journal_title：Autophagy

authors： Meijer AJ

更新日期：2009-01-01 00:00:00

abstract：:In a recent study, we reported in vivo evidence of early and sustained alterations of autophagy markers in a novel knock-in mouse model of Huntington disease (HD). The novel model is derived from selective breeding of HdhQ150 knock-in mice to generate mice with ~200 CAG/polyglutamine repeats (HdhQ200). HdhQ200 knockin...

journal_title：Autophagy

authors： Heng MY,Detloff PJ,Paulson HL,Albin RL

更新日期：2010-11-01 00:00:00

abstract：:Macroautophagy is induced under various stresses to remove cytotoxic materials, including misfolded proteins and their aggregates. These protein cargoes are collected by specific autophagic receptors such as SQSTM1/p62 (sequestosome 1) and delivered to phagophores for lysosomal degradation. To date, little is known ab...

journal_title：Autophagy

authors： Lee DH,Kim D,Kim ST,Jeong S,Kim JL,Shim SM,Heo AJ,Song X,Guo ZS,Bartlett DL,Oh SC,Lee J,Saito Y,Kim BY,Kwon YT,Lee YJ

更新日期：2018-01-01 00:00:00

abstract：:We investigated the cell-death mechanisms induced in esophageal cancer cells in response to the chemotherapeutic drugs, 5-fluorouracil (5-FU) and cisplatin. Chemosensitive cell lines exhibited apoptosis whereas chemoresistant populations exhibited autophagy and a morphology resembling type II programmed cell death (PC...

journal_title：Autophagy

authors： O'Donovan TR,O'Sullivan GC,McKenna SL

更新日期：2011-05-01 00:00:00

abstract：:Macroautophagy/autophagy is the main intracellular catabolic pathway in neurons that eliminates misfolded proteins, aggregates and damaged organelles associated with ageing and neurodegeneration. Autophagy is regulated by both MTOR-dependent and -independent pathways. There is increasing evidence that autophagy is com...

journal_title：Autophagy

authors： Perera ND,Sheean RK,Lau CL,Shin YS,Beart PM,Horne MK,Turner BJ

更新日期：2018-01-01 00:00:00

abstract：:In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea cycle and CPS1 are only present in the liver and, to a minor extent, in the kidney. To address the possibility that SIRT5 is involved i...

journal_title：Autophagy

authors： Polletta L,Vernucci E,Carnevale I,Arcangeli T,Rotili D,Palmerio S,Steegborn C,Nowak T,Schutkowski M,Pellegrini L,Sansone L,Villanova L,Runci A,Pucci B,Morgante E,Fini M,Mai A,Russo MA,Tafani M

更新日期：2015-01-01 00:00:00

abstract：:In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update the...

journal_title：Autophagy

authors： Klionsky DJ,Abdalla FC,Abeliovich H,Abraham RT,Acevedo-Arozena A,Adeli K,Agholme L,Agnello M,Agostinis P,Aguirre-Ghiso JA,Ahn HJ,Ait-Mohamed O,Ait-Si-Ali S,Akematsu T,Akira S,Al-Younes HM,Al-Zeer MA,Albert ML,Albin RL

更新日期：2012-04-01 00:00:00

abstract：:The RNA replication complexes of small positive-strand RNA viruses such as poliovirus are known to form on the surfaces of membranous vesicles in the cytoplasm of infected mammalian cells. These membranes resemble cellular autophagosomes in their double-membraned morphology, cytoplasmic lumen, lipid-rich composition a...

journal_title：Autophagy

authors： Taylor MP,Kirkegaard K

更新日期：2008-04-01 00:00:00

abstract：:Genetic inactivation of PTEN through either gene deletion or mutation is common in metastatic prostate cancer, leading to activation of the phosphoinositide 3-kinase (PI3K-AKT) pathway, which is associated with poor clinical outcomes. The PI3K-AKT pathway plays a central role in various cellular processes supporting c...

journal_title：Autophagy

authors： Lamoureux F,Zoubeidi A

更新日期：2013-07-01 00:00:00

abstract：:Cigarette smoke (CS)-induced mitochondrial damage with increased reactive oxygen species (ROS) production has been implicated in COPD pathogenesis by accelerating senescence. Mitophagy may play a pivotal role for removal of CS-induced damaged mitochondria, and the PINK1 (PTEN-induced putative kinase 1)-PARK2 pathway h...

journal_title：Autophagy

authors： Ito S,Araya J,Kurita Y,Kobayashi K,Takasaka N,Yoshida M,Hara H,Minagawa S,Wakui H,Fujii S,Kojima J,Shimizu K,Numata T,Kawaishi M,Odaka M,Morikawa T,Harada T,Nishimura SL,Kaneko Y,Nakayama K,Kuwano K

更新日期：2015-01-01 00:00:00

abstract：:Autophagy is a process by which cytoplasmic material is sequestered in a double-membrane vesicle destined for degradation. Nutrient deprivation stimulates the pathway and the number of autophagosomes in the cell increases in response to such stimulus. In the current report we have demonstrated that actin is necessary ...

journal_title：Autophagy

authors： Aguilera MO,Berón W,Colombo MI

更新日期：2012-11-01 00:00:00

abstract：:Macroautophagy/autophagy involves the formation of an autophagosome, a double-membrane vesicle that delivers sequestered cytoplasmic cargo to lysosomes for degradation and recycling. Closely related, endocytosis mediates the sorting and transport of cargo throughout the cell, and both processes are important for cellu...

journal_title：Autophagy

authors： Palmisano NJ,Rosario N,Wysocki M,Hong M,Grant B,Meléndez A

更新日期：2017-10-03 00:00:00

abstract：:The macroautophagy/autophagy-lysosome axis enables the clearance and degradation of cytoplasmic components including protein aggregates, damaged organelles and invading pathogens. Protein aggregation and lysosomal system dysfunction in the brain are common features of several late-onset neurological disorders includin...

journal_title：Autophagy

authors： Carosi JM,Hein LK,van den Hurk M,Adams R,Milky B,Singh S,Bardy C,Denton D,Kumar S,Sargeant TJ

更新日期：2020-09-22 00:00:00

abstract：:Regulated degradation of cellular components by lysosomes is essential to maintain biological homeostasis. In mammals, three forms of autophagy, macroautophagy, microautophagy and chaperone-mediated autophagy (CMA), have been identified. Here, we showed a novel type of autophagy, in which RNA is taken up directly into...

journal_title：Autophagy

authors： Fujiwara Y,Furuta A,Kikuchi H,Aizawa S,Hatanaka Y,Konya C,Uchida K,Yoshimura A,Tamai Y,Wada K,Kabuta T

更新日期：2013-03-01 00:00:00

abstract：:Here, we present a summary of our recent findings on the (patho-)physiological relevance of PINK1-phosphorylated ubiquitin (p-S65-Ub). Using novel polyclonal antibodies, we find that p-S65-Ub specifically accumulates on damaged mitochondria. Phosphorylation of ubiquitin on serine 65 depends on the activity of PINK1 an...

journal_title：Autophagy

authors： Fiesel FC,Springer W

更新日期：2015-11-02 00:00:00

abstract：:We detail here a protocol using tandem-tagged mCherry-EGFP-LC3 (C-G-LC3) to quantify autophagic flux in single cells by ratiometric flow cytometry and to isolate subpopulations of cells based on their relative levels of autophagic flux. This robust and sensitive method measures autophagic flux rather than autophagosom...

journal_title：Autophagy

authors： Gump JM,Thorburn A

更新日期：2014-07-01 00:00:00

abstract：:As a highly dynamic organelle, mitochondria undergo constitutive fusion and fission as well as biogenesis and degradation. Mitophagy, selective mitochondrial degradation through autophagy, is a conserved cellular process used for the elimination of excessive and damaged mitochondria in eukaryotes. Despite the signific...

journal_title：Autophagy

authors： Mao K,Klionsky DJ

更新日期：2013-11-01 00:00:00

abstract：:Macroautophagy is a complex process involving dynamic membrane rearrangements in which parts of the cytoplasm are sequestered within double-membrane phagophores. Upon completion, these structures mature into autophagosomes that fuse with the yeast vacuole or mammalian lysosome, leading to degradation of the cargo and ...

journal_title：Autophagy

authors： Lee WW,Klionsky DJ

更新日期：2014-05-01 00:00:00

abstract：:Phosphatidylinositol-3-phosphate (PtdIns3P) is essential for generating autophagosomes and regulating endocytic trafficking. Recently, we have shown that the activities of human PIK3C3/VPS34-containing complexes I and II, which synthesize PtdIns3P, are greatly affected by three membrane physicochemical parameters: lip...

journal_title：Autophagy

authors： Ohashi Y,Tremel S,Williams RL

更新日期：2021-01-15 00:00:00

abstract：:Macroautophagy/autophagy is a dynamic and inducible catabolic process that responds to a variety of hormonal and environmental cues. Recent studies highlight the interplay of this central pathway in a variety of pathophysiological diseases. Although defective autophagy is implicated in melanocyte proliferation and pig...

journal_title：Autophagy

authors： Ramkumar A,Murthy D,Raja DA,Singh A,Krishnan A,Khanna S,Vats A,Thukral L,Sharma P,Sivasubbu S,Rani R,Natarajan VT,Gokhale RS

更新日期：2017-08-03 00:00:00

abstract：:The initiation of macroautophagy/autophagy is tightly regulated by the upstream ULK1 kinase complex, which affects many downstream factors including the PtdIns3K complex. The phosphorylation of the right position at the right time on downstream molecules is governed by proper complex formation. One component of the UL...

journal_title：Autophagy

authors： Kim BW,Jin Y,Kim J,Kim JH,Jung J,Kang S,Kim IY,Kim J,Cheong H,Song HK

更新日期：2018-01-01 00:00:00

abstract：:The link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-rich repeat kinase 2 (LR...

journal_title：Autophagy

authors： Bravo-San Pedro JM,Gómez-Sánchez R,Niso-Santano M,Pizarro-Estrella E,Aiastui-Pujana A,Gorostidi A,Climent V,López de Maturana R,Sanchez-Pernaute R,López de Munain A,Fuentes JM,González-Polo RA

更新日期：2012-10-01 00:00:00

abstract：:Retinal ischemia is a major cause of vision loss and a common underlying mechanism associated with diseases, such as diabetic retinopathy and central retinal artery occlusion. We have previously demonstrated the robust neuroprotection in retina induced by post-conditioning (post-C), a brief period of ischemia, 24 h, f...

journal_title：Autophagy

authors： Mathew B,Chennakesavalu M,Sharma M,Torres LA,Stelman CR,Tran S,Patel R,Burg N,Salkovski M,Kadzielawa K,Seiler F,Aldrich LN,Roth S

更新日期：2020-05-26 00:00:00