Abstract:
:Autophagy is a lysosome-mediated catabolic process involving the degradation of intracellular contents (e.g., proteins and organelles) as well as invading microbes (e.g., parasites, bacteria and viruses). Multiple forms of cellular stress can stimulate this pathway, including nutritional imbalances, oxygen deprivation, immunological response, genetic defects, chromosomal anomalies and cytotoxic stress. Damage-associated molecular pattern molecules (DAMPs) are released by stressed cells undergoing autophagy or injury, and act as endogenous danger signals to regulate the subsequent inflammatory and immune response. A complex relationship exists between DAMPs and autophagy in cellular adaption to injury and unscheduled cell death. Since both autophagy and DAMPs are important for pathogenesis of human disease, it is crucial to understand how they interplay to sustain homeostasis in stressful or dangerous environments.
journal_name
Autophagyjournal_title
Autophagyauthors
Zhang Q,Kang R,Zeh HJ 3rd,Lotze MT,Tang Ddoi
10.4161/auto.23691subject
Has Abstractpub_date
2013-04-01 00:00:00pages
451-8issue
4eissn
1554-8627issn
1554-8635pii
23691journal_volume
9pub_type
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