Autophagy: The missing link between non-enzymatically glycated proteins inducing apoptosis and premature senescence of endothelial cells?

abstract：:In a recent paper we addressed the mechanism by which defective autophagy contributes to TARDBP/TDP-43-mediated neurodegenerative disorders. We demonstrated that TARDBP regulates MTORC1-TFEB signaling by targeting RPTOR/raptor, a key component and an adaptor protein of MTORC1. Loss of TARDBP decreased the mRNA stabili...

journal_title：Autophagy

authors： Ying Z,Xia Q,Hao Z,Xu D,Wang M,Wang H,Wang G

更新日期：2016-01-01 00:00:00

abstract：:In yeast, Tom22, the central component of the TOMM (translocase of outer mitochondrial membrane) receptor complex, is responsible for the recognition and translocation of synthesized mitochondrial precursor proteins, and its protein kinase CK2-dependent phosphorylation is mandatory for TOMM complex biogenesis and prop...

journal_title：Autophagy

authors： Kravic B,Harbauer AB,Romanello V,Simeone L,Vögtle FN,Kaiser T,Straubinger M,Huraskin D,Böttcher M,Cerqua C,Martin ED,Poveda-Huertes D,Buttgereit A,Rabalski AJ,Heuss D,Rudolf R,Friedrich O,Litchfield D,Marber M,Salvi

更新日期：2018-01-01 00:00:00

abstract：:Autophagy is a catabolic process employed by eukaryotes to degrade and recycle intracellular components. When this pathway is induced by starvation conditions, part of the cytoplasm and organelles are sequestered into double-membrane vesicles called autophagosomes, and delivered into the lysosome/vacuole for degradati...

journal_title：Autophagy

authors： Monastyrska I,Reggiori F,Klionsky DJ

更新日期：2008-10-01 00:00:00

abstract：:Mechanisms to protect against viral infections are crucial during pregnancy as maternal-fetal transmission can have serious pathological outcomes, including fetal infection and its sequelae, such as growth restriction, birth defects, and/or fetal death. The trophoblast forms the interface between the feto-placental un...

journal_title：Autophagy

authors： Delorme-Axford E,Bayer A,Sadovsky Y,Coyne CB

更新日期：2013-12-01 00:00:00

abstract：:Under stress conditions cells activate different response pathways which result in cell survival or apoptosis depending on: (1) the nature of the insults, (2) the type, if acute or chronic stress, and (3) how long the stress persists. Generally, autophagy is induced early to sustain cell survival and inhibit cell deat...

journal_title：Autophagy

authors： Corazzari M,Fimia GM,Piacentini M

更新日期：2012-08-01 00:00:00

abstract：:Autophagy and microRNA (miRNA) are important regulators during cancer cell tumorigenesis. Impaired autophagy and high expression of the oncogenic microRNA MIR224 are prevalent in hepatocellular carcinoma (HCC); however, the relationship between the 2 phenomena remains elusive. In this study, we are the first to reveal...

journal_title：Autophagy

authors： Lan SH,Wu SY,Zuchini R,Lin XZ,Su IJ,Tsai TF,Lin YJ,Wu CT,Liu HS

更新日期：2014-09-01 00:00:00

abstract：:Alzheimer disease (AD) is usually accompanied by two prominent pathological features, cerebral accumulation of amyloid-β (Aβ) plaques and presence of MAPT/tau neurofibrillary tangles. Dysregulated clearance of Aβ largely contributes to its accumulation and plaque formation in the brain. Macroautophagy/autophagy is a l...

journal_title：Autophagy

authors： Wani A,Al Rihani SB,Sharma A,Weadick B,Govindarajan R,Khan SU,Sharma PR,Dogra A,Nandi U,Reddy CN,Bharate SS,Singh G,Bharate SB,Vishwakarma RA,Kaddoumi A,Kumar A

更新日期：2021-01-19 00:00:00

abstract：:Macroautophagy/autophagy is a conserved catabolic process that maintains cellular homeostasis under basal growth and stress conditions. In cancer, autophagy can either prevent or promote tumor growth, at early or advanced stages, respectively. We screened public databases to identify autophagy-related somatic mutation...

journal_title：Autophagy

authors： Nuta GC,Gilad Y,Gershoni M,Sznajderman A,Schlesinger T,Bialik S,Eisenstein M,Pietrokovski S,Kimchi A

更新日期：2019-03-01 00:00:00

abstract：:Macroautophagy/autophagy is an important catabolic process for maintaining cellular homeostasis by adapting to various stress conditions. Autophagy is mediated by a double-membrane autophagosome, which sequesters a portion of cytoplasmic components for delivery to the vacuole. Several autophagy-related (ATG) genes pla...

journal_title：Autophagy

authors： Kim B,Lee Y,Choi H,Huh WK

更新日期：2020-04-02 00:00:00

abstract：:Ultraviolet (UV)-induced DNA damage is a major risk factor for skin cancers including melanoma. UVRAG, originally identified to complement UV sensitivity in xeroderma pigmentosum (XP), has since been implicated in modulating macroautophagy/autophagy, in coordinating different intracellular trafficking pathways, and in...

journal_title：Autophagy

authors： Yang Y,Quach C,Liang C

更新日期：2016-09-01 00:00:00

abstract：:In yeast and mammals, selective vacuolar delivery and degradation of whole mitochondria, or mitophagy, represents an important quality control system and is achieved by a cargo recognition mechanism enabling selective elimination of dysfunctional mitochondria. As photosynthetic organelles that need light for energy pr...

journal_title：Autophagy

authors： Izumi M,Nakamura S

更新日期：2017-07-03 00:00:00

abstract：:Autophagy is a fundamental process for anti-viral defense. Not surprisingly, viruses have developed strategies to subvert or use autophagy for their own benefit. In cell culture, autophagy proteins are proviral factors that favor initiation of hepatitis C virus (HCV) infection. Autophagy proteins are required for tran...

journal_title：Autophagy

authors： Dreux M,Chisari FV

更新日期：2009-11-01 00:00:00

abstract：:Chronic lung inflammation is accepted as being associated with the development of lung cancer caused by nickel exposure. Therefore, identifying the molecular mechanisms that lead to a nickel-induced sustained inflammatory microenvironment that causes transformation of human bronchial epithelial cells is of high signif...

journal_title：Autophagy

authors： Huang H,Zhu J,Li Y,Zhang L,Gu J,Xie Q,Jin H,Che X,Li J,Huang C,Chen LC,Lyu J,Gao J,Huang C

更新日期：2016-10-02 00:00:00

abstract：:Macroautophagy is an intracellular catabolic process involved in the formation of multiple membrane structures ranging from phagophores to autophagosomes and autolysosomes. Dysfunction of macroautophagy is implicated in both physiological and pathological conditions. To date, 38 autophagy-related (ATG) genes have been...

journal_title：Autophagy

authors： Xie Y,Kang R,Sun X,Zhong M,Huang J,Klionsky DJ,Tang D

更新日期：2015-01-01 00:00:00

abstract：:Tumor-associated inflammation is predictive of poor prognosis and drives a variety of tumorigenic phenotypes, including tumor proliferation and survival, angiogenesis, invasiveness, and metastasis. Here, we review mammalian data addressing the interaction of macroautophagy/autophagy with key signaling cascades associa...

journal_title：Autophagy

authors： Monkkonen T,Debnath J

更新日期：2018-01-01 00:00:00

abstract：:Aged and damaged mitochondria can be selectively degraded by specific autophagic elimination, termed mitophagy. Defects in mitophagy have been increasingly linked to several diseases including neurodegenerative diseases, metabolic diseases and other aging-related diseases. However, the molecular mechanisms of mitophag...

journal_title：Autophagy

authors： Xu G,Li T,Chen J,Li C,Zhao H,Yao C,Dong H,Wen K,Wang K,Zhao J,Xia Q,Zhou T,Zhang H,Gao P,Li A,Pan X

更新日期：2018-01-01 00:00:00

abstract：:Autophagy is a cellular degradation process with an increasingly recognised importance in many biological pathways such as nutrient sensing, stress responses and development. We present a straightforward assay for autophagy which combines the sensitivity of the EGFP-LC3 reporter protein with the throughput capacity an...

journal_title：Autophagy

authors： Eng KE,Panas MD,Karlsson Hedestam GB,McInerney GM

更新日期：2010-07-01 00:00:00

abstract：:Macroautophagy/autophagy involves the formation of an autophagosome, a double-membrane vesicle that delivers sequestered cytoplasmic cargo to lysosomes for degradation and recycling. Closely related, endocytosis mediates the sorting and transport of cargo throughout the cell, and both processes are important for cellu...

journal_title：Autophagy

authors： Palmisano NJ,Rosario N,Wysocki M,Hong M,Grant B,Meléndez A

更新日期：2017-10-03 00:00:00

abstract：:Neuroepithelial cells undergoing differentiation efficiently remodel their cytoskeleton and shape in an energy-consuming process. The capacity of autophagy to recycle cellular components and provide energy could fulfill these requirements, thus supporting differentiation. However, little is known regarding the role of...

journal_title：Autophagy

authors： Vázquez P,Arroba AI,Cecconi F,de la Rosa EJ,Boya P,de Pablo F

更新日期：2012-02-01 00:00:00

abstract：:The PIK3C3/VPS34-containing phosphatidylinositol 3-kinase (PtdIns3K) initiation complex (complex I) is necessary for macroautophagy/autophagy initiation and is comprised of PIK3R4/VPS15-PIK3C3/VPS34-BECN1-ATG14, while the endosomal trafficking complex (complex II) is necessary for vesicle trafficking and is comprised ...

journal_title：Autophagy

authors： Pavlinov I,Salkovski M,Aldrich LN

更新日期：2020-08-01 00:00:00

abstract：:The role of autophagy, a catabolic lysosome-dependent pathway, has recently been recognized in a variety of disorders, including Pompe disease, which results from a deficiency of the glycogen-degrading lysosomal hydrolase acid-alpha glucosidase (GAA). Skeletal and cardiac muscle are most severely affected by the progr...

journal_title：Autophagy

authors： Raben N,Baum R,Schreiner C,Takikita S,Mizushima N,Ralston E,Plotz P

更新日期：2009-01-01 00:00:00

abstract：:IRGM is a genetic risk factor for several autoimmune diseases. However, the mechanism of IRGM-mediated protection in autoimmunity remains undetermined. The abnormal activation of type I interferon (IFN) response is one of the significant factors in the pathogenesis of several autoimmune diseases. In our recent study, ...

journal_title：Autophagy

authors： Nath P,Jena KK,Mehto S,Chauhan NR,Sahu R,Dhar K,Srinivas K,Chauhan S,Chauhan S

更新日期：2020-08-19 00:00:00

abstract：:Sexual reproduction is the most common form of reproduction among eukaryotes, which is characterized by a series of massive cellular or tissue renovations. Recent studies have revealed novel functions of autophagy during sexual reproductive processes, ranging from yeast to mammals. In mammals, autophagy is indispensab...

journal_title：Autophagy

authors： Gao H,Khawar MB,Li W

更新日期：2020-01-01 00:00:00

abstract：:The conserved target of rapamycin (TOR) kinase is a central regulator of cell growth in response to nutrient availability. TOR forms 2 structurally and functionally distinct complexes, TORC1 and TORC2, and negatively regulates autophagy via TORC1. Here we demonstrate TOR also operates independently through the TORC2 s...

journal_title：Autophagy

authors： Vlahakis A,Powers T

更新日期：2014-01-01 00:00:00

abstract：:Autophagy and apoptosis are 2 fundamental biological mechanisms that may cooperate or be antagonistic, although both are involved in deciding the fate of cells in physiological or pathological conditions. These 2 mechanisms coexist simultaneously in cells and share common upstream signals and stimuli. Autophagy and ap...

journal_title：Autophagy

authors： Ravegnini G,Sammarini G,Nannini M,Pantaleo MA,Biasco G,Hrelia P,Angelini S

更新日期：2017-03-04 00:00:00

abstract：:The vascular system of plants consists of two conducting tissues, xylem and phloem, which differentiate from procambium cells. Xylem serves as a transporting system for water and signaling molecules and is formed by sequential developmental processes, including cell division/expansion, secondary cell wall deposition, ...

journal_title：Autophagy

authors： Kwon SI,Cho HJ,Park OK

更新日期：2010-11-01 00:00:00

abstract：:The relationship between macroautophagy/autophagy and miRNA in regulating cancer cell motility is not clearly delineated. Here, we found that induction of BECN1-dependent or -independent autophagy decreased ubiquitin-binding proteins SQSTM1/p62 and CALCOCO2/NDP52. Downregulation of SQSTM1 (but not CALCOCO2) led to a d...

journal_title：Autophagy

authors： Liao CC,Ho MY,Liang SM,Liang CM

更新日期：2018-01-01 00:00:00

abstract：:Regulated degradation of cellular components by lysosomes is essential to maintain biological homeostasis. In mammals, three forms of autophagy, macroautophagy, microautophagy and chaperone-mediated autophagy (CMA), have been identified. Here, we showed a novel type of autophagy, in which RNA is taken up directly into...

journal_title：Autophagy

authors： Fujiwara Y,Furuta A,Kikuchi H,Aizawa S,Hatanaka Y,Konya C,Uchida K,Yoshimura A,Tamai Y,Wada K,Kabuta T

更新日期：2013-03-01 00:00:00

abstract：:Target of rapamycin complex 1 (TORC1) is an evolutionarily conserved protein kinase complex, whose activation in response to nutrients suppresses autophagy. In mammalian cells, amino-acid stimuli induce lysosomal translocation and activation of MTORC1 through the RRAG GTPase heterodimer, which is tethered to the surfa...

journal_title：Autophagy

authors： Fukuda T,Shiozaki K

更新日期：2018-01-01 00:00:00

abstract：:Mesenchymal stem cell (MSC) transplantation has been widely applied as a potential therapeutic for multiple diseases. However, the underlying therapeutic mechanisms are not fully understood, especially the paradox between the low survival rate of transplanted cells and the beneficial therapeutic effects generated by t...

journal_title：Autophagy

authors： Liu H,Liu S,Qiu X,Yang X,Bao L,Pu F,Liu X,Li C,Xuan K,Zhou J,Deng Z,Liu S,Jin Y

更新日期：2020-12-01 00:00:00