Abstract:
:Bacterial intrusion of host cells can be recognized by the innate immune system, including autophagy, via multiple cellular pathways. We have identified Tecpr1 as an Atg5-binding partner, and found that Tecpr1 interacts with the Atg12-Atg5-Atg16L1 complex via binding to Atg5. In Shigella infected cells, Tecpr1 colocalizes with Atg5 and LC3 at Shigella-containing phagophores. Tecpr1 activity is required for efficient autophagy to target bacteria, but a deficiency of Tecpr1 in host cells does not have a marked effect on canonical autophagy. Tecpr1 plays an important role in promoting selective autophagy via the WIPI-2-Tecpr1-Atg5 pathway in targeting bacteria, protein aggregates and damaged mitochondria.
journal_name
Autophagyjournal_title
Autophagyauthors
Ogawa M,Sasakawa Cdoi
10.4161/auto.7.11.17151subject
Has Abstractpub_date
2011-11-01 00:00:00pages
1389-91issue
11eissn
1554-8627issn
1554-8635pii
17151journal_volume
7pub_type
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