Abstract:
:Autophagy helps to maintain cellular homeostasis by removing misfolded proteins and damaged organelles, and generally acts as a cytoprotective mechanism for neuronal survival. Here we showed that mice deficient in the Vici syndrome gene Epg5, which is required for autophagosome maturation, show accumulation of ubiquitin-positive inclusions and SQSTM1 aggregates in various retinal cell types. In epg5-/- retinas, photoreceptor function is greatly impaired, and degenerative features including progressively reduced numbers of photoreceptor cells and increased numbers of apoptotic cells in the outer nuclear layer are observed, while the morphology of other parts of the retina is not severely affected. Downstream targets of the unfolded protein response (UPR), including the death inducer DDIT3/CHOP, and also levels of cleaved CASP3 (caspase 3), are elevated in epg5-/- retinas. Thus, apoptotic photoreceptor cell death in epg5-/- retinas may result from the elevated UPR. Our results reveal that Epg5-deficient mice recapitulate key characteristics of retinitis pigmentosa and thus may provide a valuable model for investigating the molecular mechanism of photoreceptor degeneration.
journal_name
Autophagyjournal_title
Autophagyauthors
Miao G,Zhao YG,Zhao H,Ji C,Sun H,Chen Y,Zhang Hdoi
10.1080/15548627.2016.1238554subject
Has Abstractpub_date
2016-12-01 00:00:00pages
2263-2270issue
12eissn
1554-8627issn
1554-8635journal_volume
12pub_type
杂志文章相关文献
Autophagy文献大全abstract::The link between the deregulation of autophagy and cell death processes can be essential in the development of several neurodegenerative diseases, such as Parkinson disease (PD). However, the molecular mechanism of deregulation of this degradative process in PD patients is unknown. The leucine-rich repeat kinase 2 (LR...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.21270
更新日期:2012-10-01 00:00:00
abstract::Autophagy is a conserved homeostatic process in which cytoplasmic contents are degraded and recycled. Two ubiquitin-like conjugation pathways are required for the generation of autophagosomes, and ATG5 is necessary for both of these processes. Studies of mice deficient in ATG5 reveal a key role for autophagy in T lymp...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.23484
更新日期:2013-04-01 00:00:00
abstract::There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria via a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We thus ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1596482
更新日期:2019-11-01 00:00:00
abstract::Chronic lung inflammation is accepted as being associated with the development of lung cancer caused by nickel exposure. Therefore, identifying the molecular mechanisms that lead to a nickel-induced sustained inflammatory microenvironment that causes transformation of human bronchial epithelial cells is of high signif...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1196313
更新日期:2016-10-02 00:00:00
abstract::While autophagy is believed to be beneficial for life-span extension, it is controversial which forms or aspects of autophagy are responsible for this effect. We addressed this topic by analyzing the life span of yeast autophagy mutants under caloric restriction, a longevity manipulation. Surprisingly, we discovered t...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6556
更新日期:2008-10-01 00:00:00
abstract::Apoptosis (programmed cell death type I) and autophagy (type II) are crucial mechanisms regulating cell death and homeostasis. The Bcl-2 proto-oncogene is overexpressed in 50-70% of breast cancers, potentially leading to resistance to chemotherapy, radiation and hormone therapy-induced apoptosis. Here, we investigated...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6083
更新日期:2008-07-01 00:00:00
abstract::Although alterations of the macroautophagy/autophagy-lysosome pathway have been observed in cancer for many years, the mechanisms underlying these changes and the importance of autophagic and lysosomal reprogramming by cancer have yet to be well identified. Our recent study demonstrates that oncogenic BRAF signaling p...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1635386
更新日期:2019-10-01 00:00:00
abstract::Science informs art, and art informs science. Both processes involve creativity and imagination, and collaboration between scientists and artists often leads to new insights in both fields. We took advantage of the power of artistic imagery to demonstrate a dynamic cellular process, autophagy. In particular, we depict...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.1.10812
更新日期:2010-01-01 00:00:00
abstract:N:6-methyladenosine (m6A), the most abundant internal modification on mRNAs in eukaryotes, play roles in adipogenesis. However, the underlying mechanism remains largely unclear. Here, we show that m6A plays a critical role in regulating macroautophagy/autophagy and adipogenesis through targeting Atg5 and Atg7. Mechanis...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1659617
更新日期:2020-07-01 00:00:00
abstract::Complex membrane trafficking events are involved in the regulation of antigen processing and presentation of both endogenous and exogenous antigens. While these processes were believed to involve mainly organelles along the endo/phagocytic and the biosynthetic pathways, recent studies have shown that autophagy also pa...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.7.9163
更新日期:2009-10-01 00:00:00
abstract::Autophagy or Type II programmed cell death (PCD) is a major intracellular pathway for the degradation and recycling of proteins, ribosomes and entire organelles. The role of this pathway in the antitumor effect of radiotherapy and in radiation toxicity is obscure. A complicated machinery of genes and proteins is invol...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.5.4.7667
更新日期:2009-05-01 00:00:00
abstract::The ability to respond and adapt to changes in the physical environment is a universal and essential cellular property. Here we demonstrated that cells respond to mechanical compressive stress by rapidly inducing autophagosome formation. We measured this response in both Dictyostelium and mammalian cells, indicating t...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.12.17924
更新日期:2011-12-01 00:00:00
abstract::When no supply of environmental nutrients is available, cells induce autophagy, thereby generating a source of emergency metabolic substrates and energy to maintain the basal cellular activity needed for survival. This autophagy response to starvation has been well characterized in various multicellular organisms, inc...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.5.4.8171
更新日期:2009-05-01 00:00:00
abstract::In the world of pathogen-host cell interactions, the autophagic pathway has been recently described as a component of the innate immune response against intracellular microorganisms. Indeed, some bacterial survival mechanisms are hampered when this process is activated. Mycobacterium tuberculosis infection of macropha...
journal_title:Autophagy
pub_type: 杂志文章,评审
doi:10.4161/auto.2827
更新日期:2006-07-01 00:00:00
abstract::The extensive autophagic-lysosomal pathology in Alzheimer disease (AD) brain has revealed a major defect: in the proteolytic clearance of autophagy substrates. Autophagy failure contributes on several levels to AD pathogenesis and has become an important therapeutic target for AD and other neurodegenerative diseases. ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.7.15596
更新日期:2011-07-01 00:00:00
abstract::Coxsackievirus B3 (CVB3) has previously been shown to utilize autophagy in an advantageous manner during the course of infection of the host cell. However, few studies have determined whether stem cells induce autophagy in a similar fashion, and whether virus-induced autophagy occurs following infection of stem cells....
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.19781
更新日期:2012-06-01 00:00:00
abstract::Minocycline has been shown to alleviate several neurological disorders. Unexpectedly, we found that minocycline had opposite effects on glioma cells: minocycline induced nonapoptotic cell death in glioma cells. The glioma cell death was associated with the presence of autophagic vacuoles in the cytoplasm. Minocycline ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.2.14043
更新日期:2011-02-01 00:00:00
abstract::Macroautophagy/autophagy dysfunction is associated with many neurodegenerative diseases. TFEB (transcription factor EB), an important molecule that regulates lysosomal and autophagy function, is regarded as a potential target for treating some neurodegenerative diseases. However, the relationship between autophagy dys...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1569926
更新日期:2019-06-01 00:00:00
abstract::Atg8 and its homologs are essential for autophagosome formation in various species. In animal cells, Atg8 homologs have an additional function in clearance of damaged organelles and bacteria, acting as a landmark for selective autophagy. We have recently shown that OATL1, a Rab-GTPase-activating protein (Rab-GAP), is ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.7.9.16178
更新日期:2011-09-01 00:00:00
abstract::Autophagy is a catabolic process by which cells remove unwanted proteins and damaged organelles. It is important for maintaining cellular homeostasis and can also be used by cells to remove intracellular microbial pathogens. As such, some viruses such as herpes simplex virus-1 (HSV-1) have evolved mechanisms to suppre...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.4161/auto.6.4.11669
更新日期:2010-05-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the consequence of chronic liver damage caused by the excessive generation of reactive oxygen species (ROS). To mitigate the deleterious effects of ROS, cells activate the transcription factor NFE2L2/NRF2, which is constitutively degraded through its partner KEAP1. The inactivation of...
journal_title:Autophagy
pub_type: 评论,杂志文章
doi:10.1080/15548627.2020.1797290
更新日期:2020-10-01 00:00:00
abstract::Cutaneous inflammation from UV radiation exposure causes epidermal damage, cellular infiltration, and secretion of pro-inflammatory mediators that exacerbate tissue destruction. Recovery is mediated chiefly by anti-inflammatory M2 macrophages that suppress inflammation and augment epidermal regeneration. Vitamin D ena...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1569298
更新日期:2019-05-01 00:00:00
abstract::In yeast, Tom22, the central component of the TOMM (translocase of outer mitochondrial membrane) receptor complex, is responsible for the recognition and translocation of synthesized mitochondrial precursor proteins, and its protein kinase CK2-dependent phosphorylation is mandatory for TOMM complex biogenesis and prop...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1403716
更新日期:2018-01-01 00:00:00
abstract::A coding polymorphism of the critical autophagic effector ATG16L1 (T300A) increases the risk of Crohn disease, but how this mutation influences the function of ATG16L1 has remained unclear. In a recent report, we showed that the A300 allele alters the ability of the C-terminal WD40 domain of ATG16L1 to interact with p...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2016.1216303
更新日期:2016-11-01 00:00:00
abstract::Photoreceptor degeneration and damages often lead to blindness, and the underlying molecular mechanisms are largely unknown. There is also a lot of missing information for establishing the role of macroautophagy/autophagy in the retinopathy. We recently generated knockout mouse lines of the essential gene Tubgcp4 (tub...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2019.1647023
更新日期:2019-10-01 00:00:00
abstract::In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea cycle and CPS1 are only present in the liver and, to a minor extent, in the kidney. To address the possibility that SIRT5 is involved i...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2015.1009778
更新日期:2015-01-01 00:00:00
abstract::Post-translational modifications of autophagy-related (ATG) genes are necessary to modulate their functions. However, ATG protein methylation and its physiological role have not yet been elucidated. The methylation of non-histone proteins by SETD7, a SET domain-containing lysine methyltransferase, is a novel regulator...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1389357
更新日期:2018-01-01 00:00:00
abstract::Macroautophagy/autophagy is a dynamic and inducible catabolic process that responds to a variety of hormonal and environmental cues. Recent studies highlight the interplay of this central pathway in a variety of pathophysiological diseases. Although defective autophagy is implicated in melanocyte proliferation and pig...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2017.1327509
更新日期:2017-08-03 00:00:00
abstract::Macroautophagy/autophagy, an evolutionarily conserved eukaryotic bioprocess, plays an important role in the bulk degradation of intracellular macromolecules, organelles, and invading pathogens. PIK3C3/VPS34 (phosphatidylinositol 3-kinase catalytic subunit type 3) functions as a key protein in autophagy initiation and ...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2020.1743071
更新日期:2020-06-01 00:00:00
abstract::The initiation of macroautophagy/autophagy is tightly regulated by the upstream ULK1 kinase complex, which affects many downstream factors including the PtdIns3K complex. The phosphorylation of the right position at the right time on downstream molecules is governed by proper complex formation. One component of the UL...
journal_title:Autophagy
pub_type: 杂志文章
doi:10.1080/15548627.2018.1504716
更新日期:2018-01-01 00:00:00